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O14433 (ARGD_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetylornithine aminotransferase, mitochondrial
Short name=ACOAT
EC=2.6.1.11
Gene names
Name:ARG8
Ordered Locus Names:KLLA0E21153g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.

Cofactor

Pyridoxal phosphate.

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandPyridoxal phosphate
   Molecular functionAminotransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionN2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity

Inferred from electronic annotation. Source: EC

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 423Acetylornithine aminotransferase, mitochondrialPRO_0000002079

Amino acid modifications

Modified residue2761N6-(pyridoxal phosphate)lysine By similarity

Experimental info

Sequence conflict2271T → S in AAC49934. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O14433 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: AF0495431184440D

FASTA42346,641
        10         20         30         40         50         60 
MRVIRQLHTS KRLLQSLVDK QKYQATTYAR PNHLVLTRGK NAILYDDVNN KEYIDFTAGI 

        70         80         90        100        110        120 
AVTALGHANP EVAEIMYKQS KKLIHSSNLY YNEECLKLSE NLVEATKSFG GQYDASRVFL 

       130        140        150        160        170        180 
CNSGTEANEA ALKFAKRYGI LKSPSKQGII AFQNSFHGRT MGALSVTSNP KYREPFGSLI 

       190        200        210        220        230        240 
PGVEFLNIND ELTKLDQQVS SLKEKTAGLI VEPIQGEGGV FPIPLDTLVG LKKICEDHDI 

       250        260        270        280        290        300 
IVIYDEIQCG LGRSGKLWAH SYLPKEAHPD IFTTAKALGN GFPIAATVTN DKVNDILKVG 

       310        320        330        340        350        360 
DHGTTYGGNP LGSAVGNYVV NVIAEQKFLD EVNKKGEIIT NRLRKLQERF PEHIKDIRGK 

       370        380        390        400        410        420 
GLMIGCDFDE APAKIVDAAR DSGLLIITAG KTTVRFVPAL TIEDNLLEKG LNIFEKAVEK 


VYS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U93209 Genomic DNA. Translation: AAC49934.1.
CR382125 Genomic DNA. Translation: CAG99990.1.
PIRT50923.
RefSeqXP_454903.1. XM_454903.1.

3D structure databases

ProteinModelPortalO14433.
ModBaseSearch...

Protein-protein interaction databases

STRINGO14433.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2894291.
GenomeReviewsGene locus KLLA0E21153g in contig CR382125_GR.
KEGGkla:KLLA0E21077g.

Phylogenomic databases

eggNOGfuNOG06187.
HOGENOMHBG725944.
OMATTYARPN.
OrthoDBEOG4HMNJM.

Family and domain databases

InterProIPR004636. AcOrn/SuccinylOrn_aminoTrfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KOK00818.
PANTHERPTHR11986. Aminotrans_3. 1 hit.
PTHR11986:SF19. ArgD_aminotrans. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR00707. ArgD. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGD_KLULA
AccessionPrimary (citable) accession number: O14433
Secondary accession number(s): Q6CMD6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 27, 2004
Last modified: December 14, 2011
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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