Reviewed, UniProtKB/Swiss-Prot O14408 (KCC1_METAN)

Names and origin

Protein names	Recommended name:     Calcium/calmodulin-dependent protein kinase     EC=2.7.11.17
Organism	Metarhizium anisopliae
Taxonomic identifier	5530 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Clavicipitaceae › mitosporic Clavicipitaceae › Metarhizium

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Calcium/calmodulin-dependent protein kinase		PRO_0000086088
Regions
	Domain	23 – 278	256	Protein kinase
	Nucleotide binding	29 – 37	9	ATP By similarity
	Region	291 – 301	11	Calmodulin-binding By similarity
Sites
	Active site	142	1	Proton acceptor By similarity
	Binding site	50	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	O14408-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 9DA32959F4CA35E0	FASTA	382	43,532
	10 20 30 40 50 60 MSFAGMLNRL HGQPESYDKK SKYKFGRTLG AGTYGVVREA DGPSGKVAIK IILKKNVKGN 70 80 90 100 110 120 EKMVYAELDM LQRLTHPHIV KFVDWFESRD KFYIVTQLAT GGELFDRICD QGKFTEVDAS 130 140 150 160 170 180 QTIRQIMTAV DYLHDNDVVH RDLKPENLLY VTRDPDSDLV LADFGITKTL DIKEETLTTM 190 200 210 220 230 240 AGSFGYAAPE VMEQKGHGKP VDMWSMGVIT YTLLCGYSPF RSENLRDLLR ECTAAPVPFH 250 260 270 280 290 300 ERYWKDVSQD AKDFILVLLV PEPEKRWTSK EALGHIWLSG KNATDHNLLP ELEAYRRRAR 310 320 330 340 350 360 LRRVIEIVKL QNRIAKLKEH EEDPSESDMG DAQGASDNHK GDGSRLHALG LFAVREAKQK 370 380 QESLQVEEEL EKESRRRSFS NA

References

[1]	Joshi L., St Leger R.J., Bidochka M.J., Roberts D.W. Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ME1 / ARSEF 2575.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U28358 mRNA. Translation: AAB80685.1.
3D structure databases
HSSP	HSSP built from PDB template 1KWP based on UniProtKB P49137.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.17. 257881.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KCC1_METAN

Accession

Primary (citable) accession number: O14408

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)