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Protein

Glycerol-3-phosphate dehydrogenase, mitochondrial

Gene

gut2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FADBy similarity

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol-3-phosphate dehydrogenase, mitochondrial (gut2)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 97FADSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-SPO-163560. Triglyceride catabolism.
UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
Short name:
GPD-M
Short name:
GPDH-M
Gene namesi
Name:gut2
ORF Names:SPCC1223.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1223.03c.
PomBaseiSPCC1223.03c. gut2.

Subcellular locationi

GO - Cellular componenti

  • glycerol-3-phosphate dehydrogenase complex Source: PomBase
  • mitochondrion Source: PomBase

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000010433? – 649Glycerol-3-phosphate dehydrogenase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiO14400.
PRIDEiO14400.

Interactioni

Protein-protein interaction databases

BioGridi275787. 12 interactors.
MINTiMINT-4672763.
STRINGi4896.SPCC1223.03c.1.

Structurei

3D structure databases

ProteinModelPortaliO14400.
SMRiO14400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000004813.
InParanoidiO14400.
KOiK00111.
OMAiHIINTSK.
OrthoDBiEOG092C1H88.
PhylomeDBiO14400.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR031656. DAO_C.
IPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR000447. G3P_DH_FAD-dep.
PANTHERiPTHR11985. PTHR11985. 1 hit.
PfamiView protein in Pfam
PF01266. DAO. 1 hit.
PF16901. DAO_C. 1 hit.
PRINTSiPR01001. FADG3PDH.
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiView protein in PROSITE
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSIFKRRSV QAALAASGLV GGAVFYSDFI KRPAPSHFNP QFTPFTKSLA
60 70 80 90 100
PPPSRETLLK NVEDISKFDV LIIGGGATGT GVAVDASTRG LNVCLLEKTD
110 120 130 140 150
FASETSSKST KMAHGGVRYL EKAVFQLSKA QLDLVIEALN ERANMLRTAP
160 170 180 190 200
HLCTVLPIMI PVYKWWQVPY FFVGCKIYDW VAGSKNLRAS TIFSKETTVA
210 220 230 240 250
IAPMLDDSNL KASCVYHDGS FNDTRMNTTL AVTAIDNGAT VLNYMEVKKL
260 270 280 290 300
LKSKDNKLEG VLAIDRETGK EYQIKATSVV NATGPFSDKI LEMDADPQGE
310 320 330 340 350
PPKTAQFPRM VVPSAGVHVV LPEYYCPPNI GILDPSTSDN RVMFFLPWQG
360 370 380 390 400
KVIAGTTDKP LSSVPTNPTP SEDDIQLILK ELQKYLVFPV DREDVLSAWC
410 420 430 440 450
GIRPLVRDPS TVPPGTDPTT GETQGLVRSH FIFKSDTGLL TISGGKWTTY
460 470 480 490 500
REMAEETVNE LIKDHDFGKA LKPCQTKKLI LVGGENYYKN YSARLIHEYH
510 520 530 540 550
IPLRLAKHLS HNYGSRAPLI LELYSKTDFN KLPVTLADKE VFAPSSDASS
560 570 580 590 600
DKSVSYASFD EPFTVAELKY SIKYEYTRTP TDFLARRTRL AFLDARQALQ
610 620 630 640
AVAGVTHVMK EEFGWDDATT DKLAQEARDY IGGMGVSSDR FDVKQFEVK
Length:649
Mass (Da):71,873
Last modified:January 1, 1998 - v1
Checksum:i65702D1FDE831E6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14993 Genomic DNA. Translation: CAA75227.1.
CU329672 Genomic DNA. Translation: CAA20872.1.
PIRiT40863.
RefSeqiNP_588348.1. NM_001023339.2.

Genome annotation databases

EnsemblFungiiSPCC1223.03c.1; SPCC1223.03c.1:pep; SPCC1223.03c.
GeneIDi2539217.
KEGGispo:SPCC1223.03c.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGPDM_SCHPO
AccessioniPrimary (citable) accession number: O14400
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: July 5, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families