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Protein

Putative prephenate dehydratase

Gene

pha2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Putative prephenate dehydratase required for the syntheis of L-phenylalanine.1 Publication

Catalytic activityi

Prephenate = phenylpyruvate + H2O + CO2.

Pathwayi: L-phenylalanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phenylpyruvate from prephenate.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative prephenate dehydratase (pha2)
This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phenylpyruvate from prephenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • L-phenylalanine biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00121; UER00345.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative prephenate dehydratase (EC:4.2.1.51)
Short name:
PDT
Gene namesi
Name:pha2
ORF Names:SPBC30D10.16
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC30D10.16.
PomBaseiSPBC30D10.16. pha2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003633691 – 272Putative prephenate dehydrataseAdd BLAST272

Proteomic databases

MaxQBiO14361.
PRIDEiO14361.

Interactioni

Protein-protein interaction databases

BioGridi276849. 6 interactors.
MINTiMINT-4672641.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 180Prephenate dehydratasePROSITE-ProRule annotationAdd BLAST176
Domaini194 – 272ACTPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the PHA2 family.Curated
Contains 1 ACT domain.PROSITE-ProRule annotation
Contains 1 prephenate dehydratase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000018970.
InParanoidiO14361.
KOiK04518.
OrthoDBiEOG092C3MV0.

Family and domain databases

InterProiIPR002912. ACT_dom.
IPR001086. Preph_deHydtase.
[Graphical view]
PfamiPF00800. PDT. 1 hit.
[Graphical view]
PROSITEiPS51671. ACT. 1 hit.
PS51171. PREPHENATE_DEHYDR_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASKIAFLG PRGTFSHQAA LLARPDSLLC SLPSFAAVLE ALSSRQVDYA
60 70 80 90 100
VLPIENSTNG AVIPAYDLLK GRDDIQAVGE VLVPAHHCII GKSLENVQKI
110 120 130 140 150
LSHPQAFGQC SKWISANVPN AEFVSVSSTS QAAALASKDI TGTIVAISSE
160 170 180 190 200
LCAVENQFNL LVKNIEDDSN NRTRFLLLRS GGFQDDLSPL KEKSLLQFYL
210 220 230 240 250
SHPKKLSAVF EVFAAHKVVI TNLVVRPSCK FPWTYIYFVE CLGMEKHLID
260 270
RVGKYCDTFT FMGSYTNQIS YF
Length:272
Mass (Da):29,871
Last modified:October 3, 2012 - v2
Checksum:i3AE953662DD435CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10811.2.
PIRiT40180.
RefSeqiNP_596269.2. NM_001022190.2.

Genome annotation databases

GeneIDi2540319.
KEGGispo:SPBC30D10.16.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10811.2.
PIRiT40180.
RefSeqiNP_596269.2. NM_001022190.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276849. 6 interactors.
MINTiMINT-4672641.

Proteomic databases

MaxQBiO14361.
PRIDEiO14361.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2540319.
KEGGispo:SPBC30D10.16.

Organism-specific databases

EuPathDBiFungiDB:SPBC30D10.16.
PomBaseiSPBC30D10.16. pha2.

Phylogenomic databases

HOGENOMiHOG000018970.
InParanoidiO14361.
KOiK04518.
OrthoDBiEOG092C3MV0.

Enzyme and pathway databases

UniPathwayiUPA00121; UER00345.

Miscellaneous databases

PROiO14361.

Family and domain databases

InterProiIPR002912. ACT_dom.
IPR001086. Preph_deHydtase.
[Graphical view]
PfamiPF00800. PDT. 1 hit.
[Graphical view]
PROSITEiPS51671. ACT. 1 hit.
PS51171. PREPHENATE_DEHYDR_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPHA2_SCHPO
AccessioniPrimary (citable) accession number: O14361
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.