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O14356

- TOR1_SCHPO

UniProt

O14356 - TOR1_SCHPO

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Protein
Phosphatidylinositol 3-kinase tor1
Gene
tor1, SPBC30D10.10c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3-kinase homolog required for G1 progression and entry into stationary phase. Also required for the onset of meiosis and sporulation under nitrogen and carbon starvation conditions.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. drug binding Source: InterPro
  4. protein binding Source: IntAct
  5. protein serine/threonine kinase activity Source: PomBase
Complete GO annotation...

GO - Biological processi

  1. L-arginine import Source: PomBase
  2. TOR signaling Source: PomBase
  3. cell aging Source: PomBase
  4. cell cycle Source: UniProtKB-KW
  5. cellular response to nitrogen starvation Source: PomBase
  6. cellular response to osmotic stress Source: PomBase
  7. cellular response to starvation Source: PomBase
  8. induction of conjugation upon nitrogen starvation Source: PomBase
  9. phosphatidylinositol-mediated signaling Source: PomBase
  10. positive regulation of conjugation with cellular fusion Source: PomBase
  11. protein phosphorylation Source: GOC
  12. regulation of conjugation with cellular fusion Source: PomBase
  13. regulation of leucine import Source: PomBase
  14. response to temperature stimulus Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 5615.
ReactomeiREACT_188268. CD28 dependent PI3K/Akt signaling.
REACT_188279. PIP3 activates AKT signaling.
REACT_207307. HSF1-dependent transactivation.
REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase tor1 (EC:2.7.1.137)
Short name:
PI3-kinase tor1
Short name:
PI3K tor1
Short name:
PtdIns-3-kinase tor1
Gene namesi
Name:tor1
ORF Names:SPBC30D10.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC30D10.10c.

Subcellular locationi

GO - Cellular componenti

  1. TORC2 complex Source: PomBase
  2. cytoplasm Source: PomBase
  3. cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23352335Phosphatidylinositol 3-kinase tor1
PRO_0000088812Add
BLAST

Proteomic databases

MaxQBiO14356.

Expressioni

Inductioni

By nitrogen and/or carbon starvation, cold, osmotic and oxidative stress.1 Publication

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
tel2Q9P3W53EBI-2014420,EBI-2014377

Protein-protein interaction databases

BioGridi277001. 162 interactions.
IntActiO14356. 7 interactions.
MINTiMINT-4672581.
STRINGi4896.SPBC30D10.10c-1.

Structurei

3D structure databases

ProteinModelPortaliO14356.
SMRiO14356. Positions 2303-2335.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 3131HEAT 1
Add
BLAST
Repeati164 – 20138HEAT 2
Add
BLAST
Repeati331 – 37141HEAT 3
Add
BLAST
Repeati410 – 44940HEAT 4
Add
BLAST
Repeati474 – 51239HEAT 5
Add
BLAST
Repeati522 – 56039HEAT 6
Add
BLAST
Repeati562 – 59635HEAT 7
Add
BLAST
Repeati642 – 67938HEAT 8
Add
BLAST
Repeati684 – 72239HEAT 9
Add
BLAST
Repeati728 – 76639HEAT 10
Add
BLAST
Repeati843 – 88038HEAT 11
Add
BLAST
Repeati904 – 92320HEAT 12
Add
BLAST
Repeati924 – 96138HEAT 13
Add
BLAST
Repeati964 – 100340HEAT 14
Add
BLAST
Repeati1005 – 104238HEAT 15
Add
BLAST
Domaini1226 – 1781556FAT
Add
BLAST
Domaini1987 – 2302316PI3K/PI4K
Add
BLAST
Domaini2303 – 233533FATC
Add
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.
Contains 1 FAT domain.
Contains 1 FATC domain.
Contains 15 HEAT repeats.
Contains 1 PI3K/PI4K domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5032.
HOGENOMiHOG000163215.
KOiK07203.
OMAiNIYSARE.
OrthoDBiEOG7Z3FCR.
PhylomeDBiO14356.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR009076. Rapamycin-bd_dom.
[Graphical view]
PfamiPF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08771. Rapamycin_bind. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14356-1 [UniParc]FASTAAdd to Basket

« Hide

MEYFSDLKNK NESIQLAAAD QLKEFVHSST KELSGESLAR FNNDINRRIF     50
ELIHSHDSHE RFGGILAIGK LIEFESEGDV TNLSRYANYL RMTLPSTDWH 100
SMELSAKVLG HLAASGGTLA AEFVEFEVQR AFEWLQGDRQ EQKRMAAILI 150
IKALAQNSPT LVYLYISEIF QNLWTGLRDP KPLIRETAAD ALGASLDVVC 200
QREAKVQLQC FNEVLLQAEH GLRQSSVEYL HGSLLAYKEL FEKSGSFIRE 250
HYTEFCDLAL RLREHRDNSI RRCIVFLLPT LSEYNPKKFQ QRYLDSFMVY 300
LLSHIRKDKE KSLAFEAIGR IAMAVNEAMI PYLQNILKVI RDTLTAKVRE 350
KTQYEKPVFE CIGMLAAAVK LELLEDSRSL LGLIFSCELS VHLRQALVKM 400
AENIPPLLAP IQERLLNMVS QILTGKNFEI RTNDTYTPSF TNIYSAREPD 450
QRSKSTESII LALETLGTFN FTGYSLISFI QESVLSYLEN DNSEIRIAAA 500
RTCCQVFARD PICRKTNPLA VESVAEVLEK LLTLGIADSD PKIRETVLSL 550
LDERFDRHLA HPDNIRCLFI ALNDEVFSIR EIAIIIIGRL ALYNPAHVMP 600
SLRKTIIQLL SDMEYSGNSR QKEESAQLLK LLVSKARTLI KPYIQSIIHV 650
ILPKAADTSP GVSSAIISAL GELASVEGED MPVDVRGSFM KLILVNLQDQ 700
SSTLKRLASL KCLRKLCGRS GYVIQPYLDY PPLLGALIGI LQSEQPTPIR 750
REVLRTLGVL GALDPYTYLT TEEVSDDLQS SHNNAHGVPQ ISAAQYPSLE 800
NYAMVAVVTL IGILKDSSLS MHHSSVVQAV MHICSQMGSK STVFLPQVVP 850
TFLQVMQSLS ASSAEFYFQQ LTTLTSIIGP NIRDYVSDIF NLSKVFWEST 900
TSLLLVILEL IDAIAIALQD EFKFYLPQIL SCMLKAFSLD NTSSRSVSYK 950
VLQSFVIFGS NIEEYMHLVL PVIIRSFERD TIPLGFRKSA LKCIAQLFQS 1000
VNFSDHASRI IHPLVRMLGK SNGDLRAVIM DTLCAIVSQL GYDYSIFIPM 1050
VNKVLVSHKI SHPAYELLVS RLLKGEPLPK DVVVKEFKPR PSTKPFSTQD 1100
EVLTKLPVDQ ASLKAAWESS QKLTRDDWQD WIRRISIELL KESPSSALRS 1150
CSTLAGIYHP LARDLFNVSF LSCWDELTES NKKNLVKSIE LAMNAPNISV 1200
EILQTLLNLA EYMEREDHTL PIPIKVISAH ASKCNVYAKA LHYTELQFVQ 1250
ETKEEVSIST IESLITINNH LQQSDAAVGM LQYTKEHKQF SLKETWYEKL 1300
HRWDDALAAY EHREREGDSS FEINIGKLRC YYALGDWDHL SELAQKAWVT 1350
SEQEHREAIA PLAAAAAWGL GQWNLISEYV SAMDRDPQDK EFFSAISAVH 1400
LGQYNKAYGH IERHRDILVN DLSSIIGESY NRAYGIMVKS QMLSELEEII 1450
DYKKNMQYEN NLDSLKKTWR KRLEGCQKNV DVWHNTLRFR ALVLSPQDSP 1500
EMWIKLADLC RRSDRLKLSN QCLTYLMGRD PSNAYPLDSL KLLNPHVVYT 1550
YLKYLWATDQ KNIAVSELEE FTSYLSSKHG YKMGDSSKLV DILASSSVSS 1600
EERSFLARCF HKLGKWKKSL QDSVNQESVR DILNCYFYAT LFDKSWYKAW 1650
HSWALANFEV VGYYEQTEHG VTQDMYEQYI VPAIKGFFHS SVLNQKNSLQ 1700
DILRLLNLWF KFGEHSDVAA AIVEGFSNVP MDTWLEVIPQ LIARIHTSSS 1750
SVRASVHQLL SDIGRVHPQA LVYSLTVSSK STNPQQKHSA KSIMDSMLSH 1800
SDTLVRQALL VSQELIRVAI LWHELWYEGL EEASQAYFSD HDISLMIDIV 1850
KPLHETLEKG PSTLSEISFA QTFGYDLRKA RSYWQKFLQD GDPTELNQSW 1900
DLYYQVFRRI QKQLPRIKHL ELQYVSPKLL DACDLELAVP GTYGHNKPVI 1950
RISHFHHTFE VISSKQRPRR LTIHGSDGKD YQYVLKGHED LRQDERVMQL 2000
FGLCNTLLTT DSETFKRRLN IERYTVIPLS PNSGLLGWVP HSDTLHFLIK 2050
EFRSKRNILL NLEHRMMLQM APDCDSLTLL QKLEVFEYVM ANTDGYDLYH 2100
VLWLKSRSSE AWLDRRTSYT QSLAVMSMVG YILGLGDRHP SNLMMDRYSG 2150
KIIHIDFGDC FEVAMHREKF PEKIPFRLTR MLINAMEVSG IQGTYKITCE 2200
LVMRVLRSNT ESLMAVLEAF VYDPLINWRL MTKSSFGAST TLRPTSSSVE 2250
EKGRSYTHRA RHADYAALSE TNGVNAEGLN ERSIQVLKRV SNKLTGKDFD 2300
LKEQLPVKAQ VEKLIQQATA PENLCRCYVG WCSFW 2335
Length:2,335
Mass (Da):266,184
Last modified:January 1, 1998 - v1
Checksum:i5DCF1CF4ABE8E9A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB10805.1.
PIRiT40186.
RefSeqiNP_596275.1. NM_001022196.2.

Genome annotation databases

EnsemblFungiiSPBC30D10.10c.1; SPBC30D10.10c.1:pep; SPBC30D10.10c.
GeneIDi2540473.
KEGGispo:SPBC30D10.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB10805.1 .
PIRi T40186.
RefSeqi NP_596275.1. NM_001022196.2.

3D structure databases

ProteinModelPortali O14356.
SMRi O14356. Positions 2303-2335.
ModBasei Search...

Protein-protein interaction databases

BioGridi 277001. 162 interactions.
IntActi O14356. 7 interactions.
MINTi MINT-4672581.
STRINGi 4896.SPBC30D10.10c-1.

Proteomic databases

MaxQBi O14356.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC30D10.10c.1 ; SPBC30D10.10c.1:pep ; SPBC30D10.10c .
GeneIDi 2540473.
KEGGi spo:SPBC30D10.10c.

Organism-specific databases

PomBasei SPBC30D10.10c.

Phylogenomic databases

eggNOGi COG5032.
HOGENOMi HOG000163215.
KOi K07203.
OMAi NIYSARE.
OrthoDBi EOG7Z3FCR.
PhylomeDBi O14356.

Enzyme and pathway databases

BRENDAi 2.7.1.137. 5615.
Reactomei REACT_188268. CD28 dependent PI3K/Akt signaling.
REACT_188279. PIP3 activates AKT signaling.
REACT_207307. HSF1-dependent transactivation.
REACT_227968. Constitutive PI3K/AKT Signaling in Cancer.

Miscellaneous databases

NextBioi 20801600.

Family and domain databases

Gene3Di 1.10.1070.11. 3 hits.
1.25.10.10. 5 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR009076. Rapamycin-bd_dom.
[Graphical view ]
Pfami PF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08771. Rapamycin_bind. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine."
    Weisman R., Choder M.
    J. Biol. Chem. 276:7027-7032(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, FUNCTION, INDUCTION.

Entry informationi

Entry nameiTOR1_SCHPO
AccessioniPrimary (citable) accession number: O14356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi