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Protein

Serine/threonine-protein kinase tor1

Gene

tor1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatidylinositol 3-kinase homolog, component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases (PubMed:11409178, PubMed:11096119, PubMed:15466417, PubMed:17179073). Responsible for the phosphorylation of AGC kinase gad8 at 'Ser-527' and 'Ser-546', activating gad8 kinase activity and promoting sexual development (PubMed:12805221).5 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • macromolecular complex binding Source: InterPro
  • protein kinase activity Source: PomBase
  • protein serine/threonine kinase activity Source: PomBase

GO - Biological processi

  • cellular response to nitrogen starvation Source: PomBase
  • cellular response to osmotic stress Source: PomBase
  • DNA repair Source: GO_Central
  • induction of conjugation upon nitrogen starvation Source: PomBase
  • meiotic cell cycle Source: UniProtKB-KW
  • mitotic G1 cell cycle arrest in response to nitrogen starvation Source: PomBase
  • peptidyl-serine phosphorylation Source: PomBase
  • re-entry into mitotic cell cycle Source: PomBase
  • TORC1 signaling Source: PomBase
  • TORC2 signaling Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Meiosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 5613.
ReactomeiR-SPO-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase tor11 Publication (EC:2.7.11.11 Publication)
Alternative name(s):
Phosphatidylinositol kinase homolog tor1
Target of rapamycin kinase 1
Gene namesi
Name:tor11 Publication
ORF Names:SPBC30D10.10cImported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC30D10.10c.
PomBaseiSPBC30D10.10c. tor1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: GO_Central
  • TORC2 complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1972T → A: Increased mTOR kinase activity and stress resistance. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888121 – 2335Serine/threonine-protein kinase tor1Add BLAST2335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1972Phosphothreonine; by PKB/AKT11 Publication1

Post-translational modificationi

Phosphorylation at Thr-1972 in the ATP-binding region by AKT1 strongly reduces kinase activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14356.
PRIDEiO14356.

PTM databases

iPTMnetiO14356.

Expressioni

Inductioni

By nitrogen and/or carbon starvation, cold, osmotic and oxidative stress.1 Publication

Interactioni

Subunit structurei

The target of rapamycin complex 2 (TORC2) is composed of at least bit61, pop3/wat1, sin1, ste20 and tor1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
tel2Q9P3W53EBI-2014420,EBI-2014377

Protein-protein interaction databases

BioGridi277001. 162 interactors.
IntActiO14356. 7 interactors.
MINTiMINT-4672581.

Structurei

3D structure databases

ProteinModelPortaliO14356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 31HEAT 1Add BLAST31
Repeati164 – 201HEAT 2Add BLAST38
Repeati331 – 371HEAT 3Add BLAST41
Repeati410 – 449HEAT 4Add BLAST40
Repeati474 – 512HEAT 5Add BLAST39
Repeati522 – 560HEAT 6Add BLAST39
Repeati562 – 596HEAT 7Add BLAST35
Repeati642 – 679HEAT 8Add BLAST38
Repeati684 – 722HEAT 9Add BLAST39
Repeati728 – 766HEAT 10Add BLAST39
Repeati843 – 880HEAT 11Add BLAST38
Repeati904 – 923HEAT 12Add BLAST20
Repeati924 – 961HEAT 13Add BLAST38
Repeati964 – 1003HEAT 14Add BLAST40
Repeati1005 – 1042HEAT 15Add BLAST38
Domaini1226 – 1781FATPROSITE-ProRule annotationAdd BLAST556
Domaini1987 – 2302PI3K/PI4KPROSITE-ProRule annotationAdd BLAST316
Domaini2303 – 2335FATCPROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 15 HEAT repeats.Curated
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000163215.
InParanoidiO14356.
KOiK07203.
OrthoDBiEOG092C00HJ.
PhylomeDBiO14356.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC_dom.
IPR009076. FRB_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR026683. TOR.
[Graphical view]
PANTHERiPTHR11139:SF9. PTHR11139:SF9. 1 hit.
PfamiPF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF08771. FRB_dom. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01346. DUF3385. 1 hit.
SM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14356-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYFSDLKNK NESIQLAAAD QLKEFVHSST KELSGESLAR FNNDINRRIF
60 70 80 90 100
ELIHSHDSHE RFGGILAIGK LIEFESEGDV TNLSRYANYL RMTLPSTDWH
110 120 130 140 150
SMELSAKVLG HLAASGGTLA AEFVEFEVQR AFEWLQGDRQ EQKRMAAILI
160 170 180 190 200
IKALAQNSPT LVYLYISEIF QNLWTGLRDP KPLIRETAAD ALGASLDVVC
210 220 230 240 250
QREAKVQLQC FNEVLLQAEH GLRQSSVEYL HGSLLAYKEL FEKSGSFIRE
260 270 280 290 300
HYTEFCDLAL RLREHRDNSI RRCIVFLLPT LSEYNPKKFQ QRYLDSFMVY
310 320 330 340 350
LLSHIRKDKE KSLAFEAIGR IAMAVNEAMI PYLQNILKVI RDTLTAKVRE
360 370 380 390 400
KTQYEKPVFE CIGMLAAAVK LELLEDSRSL LGLIFSCELS VHLRQALVKM
410 420 430 440 450
AENIPPLLAP IQERLLNMVS QILTGKNFEI RTNDTYTPSF TNIYSAREPD
460 470 480 490 500
QRSKSTESII LALETLGTFN FTGYSLISFI QESVLSYLEN DNSEIRIAAA
510 520 530 540 550
RTCCQVFARD PICRKTNPLA VESVAEVLEK LLTLGIADSD PKIRETVLSL
560 570 580 590 600
LDERFDRHLA HPDNIRCLFI ALNDEVFSIR EIAIIIIGRL ALYNPAHVMP
610 620 630 640 650
SLRKTIIQLL SDMEYSGNSR QKEESAQLLK LLVSKARTLI KPYIQSIIHV
660 670 680 690 700
ILPKAADTSP GVSSAIISAL GELASVEGED MPVDVRGSFM KLILVNLQDQ
710 720 730 740 750
SSTLKRLASL KCLRKLCGRS GYVIQPYLDY PPLLGALIGI LQSEQPTPIR
760 770 780 790 800
REVLRTLGVL GALDPYTYLT TEEVSDDLQS SHNNAHGVPQ ISAAQYPSLE
810 820 830 840 850
NYAMVAVVTL IGILKDSSLS MHHSSVVQAV MHICSQMGSK STVFLPQVVP
860 870 880 890 900
TFLQVMQSLS ASSAEFYFQQ LTTLTSIIGP NIRDYVSDIF NLSKVFWEST
910 920 930 940 950
TSLLLVILEL IDAIAIALQD EFKFYLPQIL SCMLKAFSLD NTSSRSVSYK
960 970 980 990 1000
VLQSFVIFGS NIEEYMHLVL PVIIRSFERD TIPLGFRKSA LKCIAQLFQS
1010 1020 1030 1040 1050
VNFSDHASRI IHPLVRMLGK SNGDLRAVIM DTLCAIVSQL GYDYSIFIPM
1060 1070 1080 1090 1100
VNKVLVSHKI SHPAYELLVS RLLKGEPLPK DVVVKEFKPR PSTKPFSTQD
1110 1120 1130 1140 1150
EVLTKLPVDQ ASLKAAWESS QKLTRDDWQD WIRRISIELL KESPSSALRS
1160 1170 1180 1190 1200
CSTLAGIYHP LARDLFNVSF LSCWDELTES NKKNLVKSIE LAMNAPNISV
1210 1220 1230 1240 1250
EILQTLLNLA EYMEREDHTL PIPIKVISAH ASKCNVYAKA LHYTELQFVQ
1260 1270 1280 1290 1300
ETKEEVSIST IESLITINNH LQQSDAAVGM LQYTKEHKQF SLKETWYEKL
1310 1320 1330 1340 1350
HRWDDALAAY EHREREGDSS FEINIGKLRC YYALGDWDHL SELAQKAWVT
1360 1370 1380 1390 1400
SEQEHREAIA PLAAAAAWGL GQWNLISEYV SAMDRDPQDK EFFSAISAVH
1410 1420 1430 1440 1450
LGQYNKAYGH IERHRDILVN DLSSIIGESY NRAYGIMVKS QMLSELEEII
1460 1470 1480 1490 1500
DYKKNMQYEN NLDSLKKTWR KRLEGCQKNV DVWHNTLRFR ALVLSPQDSP
1510 1520 1530 1540 1550
EMWIKLADLC RRSDRLKLSN QCLTYLMGRD PSNAYPLDSL KLLNPHVVYT
1560 1570 1580 1590 1600
YLKYLWATDQ KNIAVSELEE FTSYLSSKHG YKMGDSSKLV DILASSSVSS
1610 1620 1630 1640 1650
EERSFLARCF HKLGKWKKSL QDSVNQESVR DILNCYFYAT LFDKSWYKAW
1660 1670 1680 1690 1700
HSWALANFEV VGYYEQTEHG VTQDMYEQYI VPAIKGFFHS SVLNQKNSLQ
1710 1720 1730 1740 1750
DILRLLNLWF KFGEHSDVAA AIVEGFSNVP MDTWLEVIPQ LIARIHTSSS
1760 1770 1780 1790 1800
SVRASVHQLL SDIGRVHPQA LVYSLTVSSK STNPQQKHSA KSIMDSMLSH
1810 1820 1830 1840 1850
SDTLVRQALL VSQELIRVAI LWHELWYEGL EEASQAYFSD HDISLMIDIV
1860 1870 1880 1890 1900
KPLHETLEKG PSTLSEISFA QTFGYDLRKA RSYWQKFLQD GDPTELNQSW
1910 1920 1930 1940 1950
DLYYQVFRRI QKQLPRIKHL ELQYVSPKLL DACDLELAVP GTYGHNKPVI
1960 1970 1980 1990 2000
RISHFHHTFE VISSKQRPRR LTIHGSDGKD YQYVLKGHED LRQDERVMQL
2010 2020 2030 2040 2050
FGLCNTLLTT DSETFKRRLN IERYTVIPLS PNSGLLGWVP HSDTLHFLIK
2060 2070 2080 2090 2100
EFRSKRNILL NLEHRMMLQM APDCDSLTLL QKLEVFEYVM ANTDGYDLYH
2110 2120 2130 2140 2150
VLWLKSRSSE AWLDRRTSYT QSLAVMSMVG YILGLGDRHP SNLMMDRYSG
2160 2170 2180 2190 2200
KIIHIDFGDC FEVAMHREKF PEKIPFRLTR MLINAMEVSG IQGTYKITCE
2210 2220 2230 2240 2250
LVMRVLRSNT ESLMAVLEAF VYDPLINWRL MTKSSFGAST TLRPTSSSVE
2260 2270 2280 2290 2300
EKGRSYTHRA RHADYAALSE TNGVNAEGLN ERSIQVLKRV SNKLTGKDFD
2310 2320 2330
LKEQLPVKAQ VEKLIQQATA PENLCRCYVG WCSFW
Length:2,335
Mass (Da):266,184
Last modified:January 1, 1998 - v1
Checksum:i5DCF1CF4ABE8E9A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10805.1.
PIRiT40186.
RefSeqiNP_596275.1. NM_001022196.2.

Genome annotation databases

EnsemblFungiiSPBC30D10.10c.1; SPBC30D10.10c.1:pep; SPBC30D10.10c.
GeneIDi2540473.
KEGGispo:SPBC30D10.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10805.1.
PIRiT40186.
RefSeqiNP_596275.1. NM_001022196.2.

3D structure databases

ProteinModelPortaliO14356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277001. 162 interactors.
IntActiO14356. 7 interactors.
MINTiMINT-4672581.

PTM databases

iPTMnetiO14356.

Proteomic databases

MaxQBiO14356.
PRIDEiO14356.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC30D10.10c.1; SPBC30D10.10c.1:pep; SPBC30D10.10c.
GeneIDi2540473.
KEGGispo:SPBC30D10.10c.

Organism-specific databases

EuPathDBiFungiDB:SPBC30D10.10c.
PomBaseiSPBC30D10.10c. tor1.

Phylogenomic databases

HOGENOMiHOG000163215.
InParanoidiO14356.
KOiK07203.
OrthoDBiEOG092C00HJ.
PhylomeDBiO14356.

Enzyme and pathway databases

BRENDAi2.7.1.137. 5613.
ReactomeiR-SPO-3371571. HSF1-dependent transactivation.

Miscellaneous databases

PROiO14356.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC_dom.
IPR009076. FRB_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR026683. TOR.
[Graphical view]
PANTHERiPTHR11139:SF9. PTHR11139:SF9. 1 hit.
PfamiPF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF08771. FRB_dom. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM01346. DUF3385. 1 hit.
SM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOR1_SCHPO
AccessioniPrimary (citable) accession number: O14356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.