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O14356 (TOR1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol 3-kinase tor1

Short name=PI3-kinase tor1
Short name=PI3K tor1
Short name=PtdIns-3-kinase tor1
EC=2.7.1.137
Gene names
Name:tor1
ORF Names:SPBC30D10.10c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length2335 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Phosphatidylinositol 3-kinase homolog required for G1 progression and entry into stationary phase. Also required for the onset of meiosis and sporulation under nitrogen and carbon starvation conditions. Ref.2

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

Induction

By nitrogen and/or carbon starvation, cold, osmotic and oxidative stress. Ref.2

Sequence similarities

Belongs to the PI3/PI4-kinase family.

Contains 1 FAT domain.

Contains 1 FATC domain.

Contains 15 HEAT repeats.

Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
   Biological processCell cycle
   DomainRepeat
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-arginine import

Inferred from mutant phenotype PubMed 15466417. Source: PomBase

TOR signaling

Traceable author statement PubMed 18076573. Source: PomBase

cell aging

Traceable author statement PubMed 19875745. Source: PomBase

cell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to nitrogen starvation

Inferred from mutant phenotype PubMed 11409178. Source: PomBase

cellular response to osmotic stress

Inferred from mutant phenotype PubMed 11409178. Source: PomBase

cellular response to starvation

Inferred from mutant phenotype Ref.2. Source: PomBase

induction of conjugation upon nitrogen starvation

Inferred from mutant phenotype Ref.2. Source: PomBase

phosphatidylinositol-mediated signaling

Non-traceable author statement. Source: PomBase

positive regulation of conjugation with cellular fusion

Inferred from mutant phenotype PubMed 17179073. Source: PomBase

protein phosphorylation

Inferred from direct assay PubMed 12805221. Source: GOC

regulation of conjugation with cellular fusion

Inferred from mutant phenotype PubMed 11335722. Source: PomBase

regulation of leucine import

Inferred from mutant phenotype PubMed 15466417. Source: PomBase

response to temperature stimulus

Inferred from mutant phenotype PubMed 11409178. Source: PomBase

   Cellular_componentTORC2 complex

Inferred from direct assay PubMed 17046992PubMed 17261596. Source: PomBase

cytoplasm

Inferred from direct assay PubMed 16823372. Source: PomBase

cytosol

Inferred from direct assay PubMed 16823372. Source: PomBase

   Molecular_function1-phosphatidylinositol-3-kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

drug binding

Inferred from electronic annotation. Source: InterPro

protein serine/threonine kinase activity

Inferred from direct assay PubMed 12805221. Source: PomBase

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

tel2Q9P3W53EBI-2014420,EBI-2014377

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 23352335Phosphatidylinositol 3-kinase tor1
PRO_0000088812

Regions

Repeat1 – 3131HEAT 1
Repeat164 – 20138HEAT 2
Repeat331 – 37141HEAT 3
Repeat410 – 44940HEAT 4
Repeat474 – 51239HEAT 5
Repeat522 – 56039HEAT 6
Repeat562 – 59635HEAT 7
Repeat642 – 67938HEAT 8
Repeat684 – 72239HEAT 9
Repeat728 – 76639HEAT 10
Repeat843 – 88038HEAT 11
Repeat904 – 92320HEAT 12
Repeat924 – 96138HEAT 13
Repeat964 – 100340HEAT 14
Repeat1005 – 104238HEAT 15
Domain1226 – 1781556FAT
Domain1987 – 2302316PI3K/PI4K
Domain2303 – 233533FATC

Sequences

Sequence LengthMass (Da)Tools
O14356 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 5DCF1CF4ABE8E9A4

FASTA2,335266,184
        10         20         30         40         50         60 
MEYFSDLKNK NESIQLAAAD QLKEFVHSST KELSGESLAR FNNDINRRIF ELIHSHDSHE 

        70         80         90        100        110        120 
RFGGILAIGK LIEFESEGDV TNLSRYANYL RMTLPSTDWH SMELSAKVLG HLAASGGTLA 

       130        140        150        160        170        180 
AEFVEFEVQR AFEWLQGDRQ EQKRMAAILI IKALAQNSPT LVYLYISEIF QNLWTGLRDP 

       190        200        210        220        230        240 
KPLIRETAAD ALGASLDVVC QREAKVQLQC FNEVLLQAEH GLRQSSVEYL HGSLLAYKEL 

       250        260        270        280        290        300 
FEKSGSFIRE HYTEFCDLAL RLREHRDNSI RRCIVFLLPT LSEYNPKKFQ QRYLDSFMVY 

       310        320        330        340        350        360 
LLSHIRKDKE KSLAFEAIGR IAMAVNEAMI PYLQNILKVI RDTLTAKVRE KTQYEKPVFE 

       370        380        390        400        410        420 
CIGMLAAAVK LELLEDSRSL LGLIFSCELS VHLRQALVKM AENIPPLLAP IQERLLNMVS 

       430        440        450        460        470        480 
QILTGKNFEI RTNDTYTPSF TNIYSAREPD QRSKSTESII LALETLGTFN FTGYSLISFI 

       490        500        510        520        530        540 
QESVLSYLEN DNSEIRIAAA RTCCQVFARD PICRKTNPLA VESVAEVLEK LLTLGIADSD 

       550        560        570        580        590        600 
PKIRETVLSL LDERFDRHLA HPDNIRCLFI ALNDEVFSIR EIAIIIIGRL ALYNPAHVMP 

       610        620        630        640        650        660 
SLRKTIIQLL SDMEYSGNSR QKEESAQLLK LLVSKARTLI KPYIQSIIHV ILPKAADTSP 

       670        680        690        700        710        720 
GVSSAIISAL GELASVEGED MPVDVRGSFM KLILVNLQDQ SSTLKRLASL KCLRKLCGRS 

       730        740        750        760        770        780 
GYVIQPYLDY PPLLGALIGI LQSEQPTPIR REVLRTLGVL GALDPYTYLT TEEVSDDLQS 

       790        800        810        820        830        840 
SHNNAHGVPQ ISAAQYPSLE NYAMVAVVTL IGILKDSSLS MHHSSVVQAV MHICSQMGSK 

       850        860        870        880        890        900 
STVFLPQVVP TFLQVMQSLS ASSAEFYFQQ LTTLTSIIGP NIRDYVSDIF NLSKVFWEST 

       910        920        930        940        950        960 
TSLLLVILEL IDAIAIALQD EFKFYLPQIL SCMLKAFSLD NTSSRSVSYK VLQSFVIFGS 

       970        980        990       1000       1010       1020 
NIEEYMHLVL PVIIRSFERD TIPLGFRKSA LKCIAQLFQS VNFSDHASRI IHPLVRMLGK 

      1030       1040       1050       1060       1070       1080 
SNGDLRAVIM DTLCAIVSQL GYDYSIFIPM VNKVLVSHKI SHPAYELLVS RLLKGEPLPK 

      1090       1100       1110       1120       1130       1140 
DVVVKEFKPR PSTKPFSTQD EVLTKLPVDQ ASLKAAWESS QKLTRDDWQD WIRRISIELL 

      1150       1160       1170       1180       1190       1200 
KESPSSALRS CSTLAGIYHP LARDLFNVSF LSCWDELTES NKKNLVKSIE LAMNAPNISV 

      1210       1220       1230       1240       1250       1260 
EILQTLLNLA EYMEREDHTL PIPIKVISAH ASKCNVYAKA LHYTELQFVQ ETKEEVSIST 

      1270       1280       1290       1300       1310       1320 
IESLITINNH LQQSDAAVGM LQYTKEHKQF SLKETWYEKL HRWDDALAAY EHREREGDSS 

      1330       1340       1350       1360       1370       1380 
FEINIGKLRC YYALGDWDHL SELAQKAWVT SEQEHREAIA PLAAAAAWGL GQWNLISEYV 

      1390       1400       1410       1420       1430       1440 
SAMDRDPQDK EFFSAISAVH LGQYNKAYGH IERHRDILVN DLSSIIGESY NRAYGIMVKS 

      1450       1460       1470       1480       1490       1500 
QMLSELEEII DYKKNMQYEN NLDSLKKTWR KRLEGCQKNV DVWHNTLRFR ALVLSPQDSP 

      1510       1520       1530       1540       1550       1560 
EMWIKLADLC RRSDRLKLSN QCLTYLMGRD PSNAYPLDSL KLLNPHVVYT YLKYLWATDQ 

      1570       1580       1590       1600       1610       1620 
KNIAVSELEE FTSYLSSKHG YKMGDSSKLV DILASSSVSS EERSFLARCF HKLGKWKKSL 

      1630       1640       1650       1660       1670       1680 
QDSVNQESVR DILNCYFYAT LFDKSWYKAW HSWALANFEV VGYYEQTEHG VTQDMYEQYI 

      1690       1700       1710       1720       1730       1740 
VPAIKGFFHS SVLNQKNSLQ DILRLLNLWF KFGEHSDVAA AIVEGFSNVP MDTWLEVIPQ 

      1750       1760       1770       1780       1790       1800 
LIARIHTSSS SVRASVHQLL SDIGRVHPQA LVYSLTVSSK STNPQQKHSA KSIMDSMLSH 

      1810       1820       1830       1840       1850       1860 
SDTLVRQALL VSQELIRVAI LWHELWYEGL EEASQAYFSD HDISLMIDIV KPLHETLEKG 

      1870       1880       1890       1900       1910       1920 
PSTLSEISFA QTFGYDLRKA RSYWQKFLQD GDPTELNQSW DLYYQVFRRI QKQLPRIKHL 

      1930       1940       1950       1960       1970       1980 
ELQYVSPKLL DACDLELAVP GTYGHNKPVI RISHFHHTFE VISSKQRPRR LTIHGSDGKD 

      1990       2000       2010       2020       2030       2040 
YQYVLKGHED LRQDERVMQL FGLCNTLLTT DSETFKRRLN IERYTVIPLS PNSGLLGWVP 

      2050       2060       2070       2080       2090       2100 
HSDTLHFLIK EFRSKRNILL NLEHRMMLQM APDCDSLTLL QKLEVFEYVM ANTDGYDLYH 

      2110       2120       2130       2140       2150       2160 
VLWLKSRSSE AWLDRRTSYT QSLAVMSMVG YILGLGDRHP SNLMMDRYSG KIIHIDFGDC 

      2170       2180       2190       2200       2210       2220 
FEVAMHREKF PEKIPFRLTR MLINAMEVSG IQGTYKITCE LVMRVLRSNT ESLMAVLEAF 

      2230       2240       2250       2260       2270       2280 
VYDPLINWRL MTKSSFGAST TLRPTSSSVE EKGRSYTHRA RHADYAALSE TNGVNAEGLN 

      2290       2300       2310       2320       2330 
ERSIQVLKRV SNKLTGKDFD LKEQLPVKAQ VEKLIQQATA PENLCRCYVG WCSFW 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine."
Weisman R., Choder M.
J. Biol. Chem. 276:7027-7032(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, FUNCTION, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAB10805.1.
PIRT40186.
RefSeqNP_596275.1. NM_001022196.2.

3D structure databases

ProteinModelPortalO14356.
SMRO14356. Positions 2303-2335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277001. 162 interactions.
IntActO14356. 7 interactions.
MINTMINT-4672581.
STRING4896.SPBC30D10.10c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC30D10.10c.1; SPBC30D10.10c.1:pep; SPBC30D10.10c.
GeneID2540473.
KEGGspo:SPBC30D10.10c.

Organism-specific databases

PomBaseSPBC30D10.10c.

Phylogenomic databases

eggNOGCOG5032.
HOGENOMHOG000163215.
KOK07203.
OMANDINRRI.
OrthoDBEOG7Z3FCR.
PhylomeDBO14356.

Enzyme and pathway databases

BRENDA2.7.1.137. 5615.

Family and domain databases

Gene3D1.10.1070.11. 3 hits.
1.25.10.10. 5 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024585. DUF3385_TOR.
IPR003152. FATC.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR009076. Rapamycin-bd_dom.
IPR026683. TOR.
[Graphical view]
PANTHERPTHR11139:SF9. PTHR11139:SF9. 1 hit.
PfamPF11865. DUF3385. 1 hit.
PF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF08771. Rapamycin_bind. 1 hit.
[Graphical view]
SMARTSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF47212. SSF47212. 1 hit.
SSF48371. SSF48371. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20801600.

Entry information

Entry nameTOR1_SCHPO
AccessionPrimary (citable) accession number: O14356
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names