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Protein

Kinesin-like protein 5

Gene

klp5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi144 – 1518ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • attachment of mitotic spindle microtubules to kinetochore Source: PomBase
  • meiotic nuclear division Source: PomBase
  • microtubule-based movement Source: InterPro
  • microtubule cytoskeleton organization involved in mitosis Source: PomBase
  • mitotic actomyosin contractile ring assembly Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein 5
Gene namesi
Name:klp5
ORF Names:SPBC2F12.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2F12.13.
PomBaseiSPBC2F12.13. klp5.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmcytoskeleton 1 Publication
  • Chromosomecentromerekinetochore 1 Publication
  • Cytoplasmcytoskeletonspindle 1 Publication

  • Note: Cytoplasmic microtubules in interphase, mitotic kinetochores in metaphase and spindle midzone in anaphase and telophase.

GO - Cellular componenti

  • condensed nuclear chromosome kinetochore Source: PomBase
  • cytoplasm Source: PomBase
  • cytosol Source: Reactome
  • microtubule Source: UniProtKB-KW
  • microtubule cytoskeleton Source: PomBase
  • mitotic spindle midzone Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nucleus Source: PomBase
  • plus-end kinesin complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 883883Kinesin-like protein 5PRO_0000125388Add
BLAST

Proteomic databases

MaxQBiO14343.
PRIDEiO14343.

Interactioni

Subunit structurei

Heterodimer with klp6.

Binary interactionsi

WithEntry#Exp.IntActNotes
klp6O597513EBI-1561765,EBI-1561745

Protein-protein interaction databases

BioGridi276890. 61 interactions.
IntActiO14343. 2 interactions.
MINTiMINT-4672457.

Structurei

3D structure databases

ProteinModelPortaliO14343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 390385Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili396 – 43540Sequence analysisAdd
BLAST
Coiled coili563 – 58826Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000183905.
InParanoidiO14343.
KOiK10401.
OrthoDBiEOG7RRFGF.
PhylomeDBiO14343.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 5 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSSITVT VRVRPFSTAE SANLIASSDR LSFGTSSSLR NPGSGRQIRR
60 70 80 90 100
VVKVLDGRVL VFDPPDETTA TLSATNRRLS TSQQSLARLS RKSNNSAGFG
110 120 130 140 150
RDLRYAFDRV FDETATQQQV YERTARPLLD NILDGFNATI FAYGATGCGK
160 170 180 190 200
THTISGTMQD PGLIYLTLKE LFERMDHLRD EKIFDLRLSY LEIYNETIRD
210 220 230 240 250
LLVSPTPNQA KPLNLREDAD RRITVPGLTS LSPESLEEII DIIMKGNANR
260 270 280 290 300
TMSPTEANAA SSRSHAVLQV TLIQKPRTAG INEDHTLATL SIIDLAGSER
310 320 330 340 350
ATATKLRGSR LFEGANINKS LLALGNCINA LCDPHRRAHV PYRDSKLTRL
360 370 380 390 400
LKFSLGGNCR TVMIVCVSPS SVHYEETHNT LKYANRAKNI KTEVLRNMIS
410 420 430 440 450
VDRHVSQYVK AIVELREQIS ELENRLAQID LSSQSNGSDQ DAVTQSFAHE
460 470 480 490 500
SKLAEARNLL RMTFEETLPL QNDTINKVEK VKHFDDSIRV LKYWLSCYER
510 520 530 540 550
ILPNSADERV FLVRSKLESL LTRRAEIIAD IDPELVYQKF QRSVSHIINT
560 570 580 590 600
YKQEGATMYA DVLQDEVDLL KSIIENQVLD AQNKVDEFTP VLESLLRSSF
610 620 630 640 650
KASSLLKEGG MQELFSILEK WLLGIGLGEK PNISVLSESY KLNSTSDDSR
660 670 680 690 700
TINRDRVHSF PTQPLLNNNL PRMFFVKSPK KPVVFSKRSP KKRVRFDDSM
710 720 730 740 750
STSDSGASAY NSPIQTSKLK NMNFFNTMHM PSTPAHKRPE NKNQIDVEIN
760 770 780 790 800
LTSPVSPMLE DKPEPGLLIK SPLEKKQEVN SESTQLDQLL AEDSSTDDVS
810 820 830 840 850
LPHLDTIDLD GSPVPKVPDL NFSRANMDSP TFILNNEAIH NFDFSKPKTR
860 870 880
QSLSSLTTLH LSNPANIIRK SLSMAENEEE KAT
Length:883
Mass (Da):99,059
Last modified:January 1, 1998 - v1
Checksum:iBB8A60E22DA397E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072924 Genomic DNA. Translation: BAB69885.1.
CU329671 Genomic DNA. Translation: CAB10160.1.
PIRiT40128.
RefSeqiNP_595703.1. NM_001021600.2.

Genome annotation databases

EnsemblFungiiSPBC2F12.13.1; SPBC2F12.13.1:pep; SPBC2F12.13.
GeneIDi2540361.
KEGGispo:SPBC2F12.13.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072924 Genomic DNA. Translation: BAB69885.1.
CU329671 Genomic DNA. Translation: CAB10160.1.
PIRiT40128.
RefSeqiNP_595703.1. NM_001021600.2.

3D structure databases

ProteinModelPortaliO14343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276890. 61 interactions.
IntActiO14343. 2 interactions.
MINTiMINT-4672457.

Proteomic databases

MaxQBiO14343.
PRIDEiO14343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC2F12.13.1; SPBC2F12.13.1:pep; SPBC2F12.13.
GeneIDi2540361.
KEGGispo:SPBC2F12.13.

Organism-specific databases

EuPathDBiFungiDB:SPBC2F12.13.
PomBaseiSPBC2F12.13. klp5.

Phylogenomic databases

HOGENOMiHOG000183905.
InParanoidiO14343.
KOiK10401.
OrthoDBiEOG7RRFGF.
PhylomeDBiO14343.

Miscellaneous databases

NextBioi20801489.
PROiO14343.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 5 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two kinesin-like Kin I family proteins in fission yeast regulate the establishment of metaphase and the onset of anaphase A."
    Garcia M.A., Koonrugsa N., Toda T.
    Curr. Biol. 12:610-621(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH KLP6, SUBCELLULAR LOCATION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiKLP5_SCHPO
AccessioniPrimary (citable) accession number: O14343
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.