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Protein

Kinesin-like protein 5

Gene

klp5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi144 – 151ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: PomBase
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: PomBase
  • microtubule binding Source: PomBase

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chromosome movement towards spindle pole Source: PomBase
  • cytoplasmic microtubule depolymerization Source: PomBase
  • deactivation of mitotic spindle assembly checkpoint Source: PomBase
  • lateral attachment of mitotic spindle microtubules to kinetochore Source: PomBase
  • microtubule depolymerization Source: PomBase
  • mitotic metaphase chromosome recapture Source: PomBase
  • mitotic sister chromatid biorientation Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • mitotic spindle organization Source: PomBase
  • protein localization to kinetochore Source: PomBase

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Chromosome partition, Mitosis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein 5
Gene namesi
Name:klp5
ORF Names:SPBC2F12.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2F12.13
PomBaseiSPBC2F12.13 klp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253881 – 883Kinesin-like protein 5Add BLAST883

Proteomic databases

MaxQBiO14343
PaxDbiO14343
PRIDEiO14343

PTM databases

iPTMnetiO14343

Interactioni

Subunit structurei

Heterodimer with klp6.

Binary interactionsi

WithEntry#Exp.IntActNotes
klp6O597513EBI-1561765,EBI-1561745

GO - Molecular functioni

  • microtubule binding Source: PomBase

Protein-protein interaction databases

BioGridi276890, 63 interactors
IntActiO14343, 2 interactors
STRINGi4896.SPBC2F12.13.1

Structurei

3D structure databases

ProteinModelPortaliO14343
SMRiO14343
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 390Kinesin motorPROSITE-ProRule annotationAdd BLAST385

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili396 – 435Sequence analysisAdd BLAST40
Coiled coili563 – 588Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000183905
InParanoidiO14343
KOiK10401
OrthoDBiEOG092C2D4G
PhylomeDBiO14343

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O14343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQSSITVT VRVRPFSTAE SANLIASSDR LSFGTSSSLR NPGSGRQIRR
60 70 80 90 100
VVKVLDGRVL VFDPPDETTA TLSATNRRLS TSQQSLARLS RKSNNSAGFG
110 120 130 140 150
RDLRYAFDRV FDETATQQQV YERTARPLLD NILDGFNATI FAYGATGCGK
160 170 180 190 200
THTISGTMQD PGLIYLTLKE LFERMDHLRD EKIFDLRLSY LEIYNETIRD
210 220 230 240 250
LLVSPTPNQA KPLNLREDAD RRITVPGLTS LSPESLEEII DIIMKGNANR
260 270 280 290 300
TMSPTEANAA SSRSHAVLQV TLIQKPRTAG INEDHTLATL SIIDLAGSER
310 320 330 340 350
ATATKLRGSR LFEGANINKS LLALGNCINA LCDPHRRAHV PYRDSKLTRL
360 370 380 390 400
LKFSLGGNCR TVMIVCVSPS SVHYEETHNT LKYANRAKNI KTEVLRNMIS
410 420 430 440 450
VDRHVSQYVK AIVELREQIS ELENRLAQID LSSQSNGSDQ DAVTQSFAHE
460 470 480 490 500
SKLAEARNLL RMTFEETLPL QNDTINKVEK VKHFDDSIRV LKYWLSCYER
510 520 530 540 550
ILPNSADERV FLVRSKLESL LTRRAEIIAD IDPELVYQKF QRSVSHIINT
560 570 580 590 600
YKQEGATMYA DVLQDEVDLL KSIIENQVLD AQNKVDEFTP VLESLLRSSF
610 620 630 640 650
KASSLLKEGG MQELFSILEK WLLGIGLGEK PNISVLSESY KLNSTSDDSR
660 670 680 690 700
TINRDRVHSF PTQPLLNNNL PRMFFVKSPK KPVVFSKRSP KKRVRFDDSM
710 720 730 740 750
STSDSGASAY NSPIQTSKLK NMNFFNTMHM PSTPAHKRPE NKNQIDVEIN
760 770 780 790 800
LTSPVSPMLE DKPEPGLLIK SPLEKKQEVN SESTQLDQLL AEDSSTDDVS
810 820 830 840 850
LPHLDTIDLD GSPVPKVPDL NFSRANMDSP TFILNNEAIH NFDFSKPKTR
860 870 880
QSLSSLTTLH LSNPANIIRK SLSMAENEEE KAT
Length:883
Mass (Da):99,059
Last modified:January 1, 1998 - v1
Checksum:iBB8A60E22DA397E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072924 Genomic DNA Translation: BAB69885.1
CU329671 Genomic DNA Translation: CAB10160.1
PIRiT40128
RefSeqiNP_595703.1, NM_001021600.2

Genome annotation databases

EnsemblFungiiSPBC2F12.13.1; SPBC2F12.13.1:pep; SPBC2F12.13
GeneIDi2540361
KEGGispo:SPBC2F12.13

Similar proteinsi

Entry informationi

Entry nameiKLP5_SCHPO
AccessioniPrimary (citable) accession number: O14343
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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