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Protein

Oxysterol-binding protein homolog C2F12.05c

Gene

SPBC2F12.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-SPO-192105 Synthesis of bile acids and bile salts

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein homolog C2F12.05c
Gene namesi
ORF Names:SPBC2F12.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2F12.05c
PomBaseiSPBC2F12.05c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003941 – 1310Oxysterol-binding protein homolog C2F12.05cAdd BLAST1310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei384Phosphoserine1 Publication1
Modified residuei394Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14340
PaxDbiO14340
PRIDEiO14340

PTM databases

iPTMnetiO14340

Interactioni

Subunit structurei

Interacts with dil1.1 Publication

Protein-protein interaction databases

BioGridi276886, 20 interactors
IntActiO14340, 1 interactor
STRINGi4896.SPBC2F12.05c.1

Structurei

3D structure databases

ProteinModelPortaliO14340
SMRiO14340
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati54 – 84ANK 1Add BLAST31
Repeati88 – 118ANK 2Add BLAST31
Repeati188 – 217ANK 3Add BLAST30
Domaini254 – 349PHPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Belongs to the OSBP family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

InParanoidiO14340
KOiK20456
OMAiKQPTEGQ
OrthoDBiEOG092C0GJ4
PhylomeDBiO14340

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

O14340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHPSPDSVS STSSSDHKKA ELSDSLKQLQ LLQAFQAGDI KQVDNLLHNK
60 70 80 90 100
SKDECTHALF ISIQCANVQM VKHILSVFDV DVNAYDKNKN TPLHLAAMAG
110 120 130 140 150
RQDIVEALLL HPDINYNLVN ANNKKAYQVA TSPQLMDFMK GFYVTYTKET
160 170 180 190 200
AREFKKAFKE RNLESMDYLM RHNEFNDAID LNEVDIKTGQ TYLHVATKAK
210 220 230 240 250
DAELVKWLLD NGADPYRRDK FGKLPTDYTK DENMRSLLRS YSGNRDSSSA
260 270 280 290 300
PAVPQHMSGY LKKWTNYKSG YKLRWFTLNN GVLSYYKNQD DASSACRGSI
310 320 330 340 350
NLKLARLVHD PKQPTVFQVI GKGSVRYSVK ANSPVEAKKW IAAISSAIEN
360 370 380 390 400
DEEANKPNVT ADNASFGTHD LAPAAHKFTQ SNASGNSGWD DNESDIDRAQ
410 420 430 440 450
LPSRENFEFN VNIAKLQVET LHKLIDSAMQ TEKVKKDPSL SQVFDGISNS
460 470 480 490 500
FNTLHKTVLE MLDLQRQAEH YYKRKLDNAK AINALWAENL KTVVEEQDQI
510 520 530 540 550
EERYHRSEAH RRRTKRAFRR LAASLKKRPS DKDNKLHIHY DDGAMSSTSY
560 570 580 590 600
STDFTDDEEE TNTKDEFFDV DAHDNNHANK AEPSQTANNV HEIREPSFSS
610 620 630 640 650
EHKPQPSLKT TTDVSSPETK QNIADIRKTT LTDQTEEFTE RRDNNGSIPS
660 670 680 690 700
KQPSDEQHLG KESLPSQQST VSNHHRKESI PSKQPTEGQH ARQESLPSQQ
710 720 730 740 750
TTETKHLRKE STPSKQPTEG QHTRQESLPS QQTTETKHLR KESIPSKQPT
760 770 780 790 800
EGQHARQESL PSQQTTETKH LRKESIPSKQ PSGGQQLRQE SLPSQQSSES
810 820 830 840 850
KQSTQHQQPV EVQKSIQSDV SAPKAKEVSE KPVSHQAKPS NASQLSRNTD
860 870 880 890 900
DTQAKEAPKE ASIPDNASTA STKVSNDSHL KPDADKKSVS SELTHASKPS
910 920 930 940 950
LDEKTMQLAK QIAVSFHGYE APTRENLDVN DDRPKISLWG ILKGMIGKDM
960 970 980 990 1000
TKMTLPVSFN EPTSLLQRVA EDMEYTELLD QASHNKDPYQ RILYVAAFAA
1010 1020 1030 1040 1050
SEYASTLNRV AKPFNPLLGE TYEFCHPQRG FRFIVEQVSH HPPVGAAYSE
1060 1070 1080 1090 1100
SANWKYYGES SVKSKFYGKS FDISPLGTWF LELRHPSGEV ELYTWKKVTS
1110 1120 1130 1140 1150
SVVGIILGSP SVDNYGQMHI VNHSSGINCV LDFKPRGWRG TNAHEVKGSV
1160 1170 1180 1190 1200
QSTDDTPKWM VNGHWNDKIF GQQPNGNKIL LWQNHERPPR PFNLTPFAIS
1210 1220 1230 1240 1250
LNALTPQLKP WLPPTDTRLR PDQRAMENGQ YDLAASEKNR LEEKQRKKRR
1260 1270 1280 1290 1300
MREQGEMPPW SPRWFSAAKH PVTGEDYWQF NNEYWKIREE AGEAHLAGKE
1310
FEWPNVDDIF
Length:1,310
Mass (Da):148,475
Last modified:May 1, 2000 - v2
Checksum:iE6F284F09C073262
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB10154.2
PIRiT40135
RefSeqiNP_595710.1, NM_001021607.2

Genome annotation databases

EnsemblFungiiSPBC2F12.05c.1; SPBC2F12.05c.1:pep; SPBC2F12.05c
GeneIDi2540357
KEGGispo:SPBC2F12.05c

Entry informationi

Entry nameiYB35_SCHPO
AccessioniPrimary (citable) accession number: O14340
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health