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Protein

Oxysterol-binding protein homolog C2F12.05c

Gene

SPBC2F12.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein homolog C2F12.05c
Gene namesi
ORF Names:SPBC2F12.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2F12.05c.
PomBaseiSPBC2F12.05c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • endoplasmic reticulum Source: PomBase
  • protein complex Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13101310Oxysterol-binding protein homolog C2F12.05cPRO_0000100394Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei384 – 3841Phosphoserine1 Publication
Modified residuei394 – 3941Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14340.

PTM databases

iPTMnetiO14340.

Interactioni

Subunit structurei

Interacts with dil1.1 Publication

Protein-protein interaction databases

BioGridi276886. 20 interactions.
IntActiO14340. 1 interaction.
MINTiMINT-4672432.

Structurei

3D structure databases

ProteinModelPortaliO14340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 8431ANK 1Add
BLAST
Repeati88 – 11831ANK 2Add
BLAST
Repeati188 – 21730ANK 3Add
BLAST
Domaini254 – 34996PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the OSBP family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

InParanoidiO14340.
KOiK06867.
OMAiKQPTEGQ.
OrthoDBiEOG7N903T.
PhylomeDBiO14340.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 3 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHPSPDSVS STSSSDHKKA ELSDSLKQLQ LLQAFQAGDI KQVDNLLHNK
60 70 80 90 100
SKDECTHALF ISIQCANVQM VKHILSVFDV DVNAYDKNKN TPLHLAAMAG
110 120 130 140 150
RQDIVEALLL HPDINYNLVN ANNKKAYQVA TSPQLMDFMK GFYVTYTKET
160 170 180 190 200
AREFKKAFKE RNLESMDYLM RHNEFNDAID LNEVDIKTGQ TYLHVATKAK
210 220 230 240 250
DAELVKWLLD NGADPYRRDK FGKLPTDYTK DENMRSLLRS YSGNRDSSSA
260 270 280 290 300
PAVPQHMSGY LKKWTNYKSG YKLRWFTLNN GVLSYYKNQD DASSACRGSI
310 320 330 340 350
NLKLARLVHD PKQPTVFQVI GKGSVRYSVK ANSPVEAKKW IAAISSAIEN
360 370 380 390 400
DEEANKPNVT ADNASFGTHD LAPAAHKFTQ SNASGNSGWD DNESDIDRAQ
410 420 430 440 450
LPSRENFEFN VNIAKLQVET LHKLIDSAMQ TEKVKKDPSL SQVFDGISNS
460 470 480 490 500
FNTLHKTVLE MLDLQRQAEH YYKRKLDNAK AINALWAENL KTVVEEQDQI
510 520 530 540 550
EERYHRSEAH RRRTKRAFRR LAASLKKRPS DKDNKLHIHY DDGAMSSTSY
560 570 580 590 600
STDFTDDEEE TNTKDEFFDV DAHDNNHANK AEPSQTANNV HEIREPSFSS
610 620 630 640 650
EHKPQPSLKT TTDVSSPETK QNIADIRKTT LTDQTEEFTE RRDNNGSIPS
660 670 680 690 700
KQPSDEQHLG KESLPSQQST VSNHHRKESI PSKQPTEGQH ARQESLPSQQ
710 720 730 740 750
TTETKHLRKE STPSKQPTEG QHTRQESLPS QQTTETKHLR KESIPSKQPT
760 770 780 790 800
EGQHARQESL PSQQTTETKH LRKESIPSKQ PSGGQQLRQE SLPSQQSSES
810 820 830 840 850
KQSTQHQQPV EVQKSIQSDV SAPKAKEVSE KPVSHQAKPS NASQLSRNTD
860 870 880 890 900
DTQAKEAPKE ASIPDNASTA STKVSNDSHL KPDADKKSVS SELTHASKPS
910 920 930 940 950
LDEKTMQLAK QIAVSFHGYE APTRENLDVN DDRPKISLWG ILKGMIGKDM
960 970 980 990 1000
TKMTLPVSFN EPTSLLQRVA EDMEYTELLD QASHNKDPYQ RILYVAAFAA
1010 1020 1030 1040 1050
SEYASTLNRV AKPFNPLLGE TYEFCHPQRG FRFIVEQVSH HPPVGAAYSE
1060 1070 1080 1090 1100
SANWKYYGES SVKSKFYGKS FDISPLGTWF LELRHPSGEV ELYTWKKVTS
1110 1120 1130 1140 1150
SVVGIILGSP SVDNYGQMHI VNHSSGINCV LDFKPRGWRG TNAHEVKGSV
1160 1170 1180 1190 1200
QSTDDTPKWM VNGHWNDKIF GQQPNGNKIL LWQNHERPPR PFNLTPFAIS
1210 1220 1230 1240 1250
LNALTPQLKP WLPPTDTRLR PDQRAMENGQ YDLAASEKNR LEEKQRKKRR
1260 1270 1280 1290 1300
MREQGEMPPW SPRWFSAAKH PVTGEDYWQF NNEYWKIREE AGEAHLAGKE
1310
FEWPNVDDIF
Length:1,310
Mass (Da):148,475
Last modified:May 1, 2000 - v2
Checksum:iE6F284F09C073262
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10154.2.
PIRiT40135.
RefSeqiNP_595710.1. NM_001021607.2.

Genome annotation databases

EnsemblFungiiSPBC2F12.05c.1; SPBC2F12.05c.1:pep; SPBC2F12.05c.
GeneIDi2540357.
KEGGispo:SPBC2F12.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10154.2.
PIRiT40135.
RefSeqiNP_595710.1. NM_001021607.2.

3D structure databases

ProteinModelPortaliO14340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276886. 20 interactions.
IntActiO14340. 1 interaction.
MINTiMINT-4672432.

PTM databases

iPTMnetiO14340.

Proteomic databases

MaxQBiO14340.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC2F12.05c.1; SPBC2F12.05c.1:pep; SPBC2F12.05c.
GeneIDi2540357.
KEGGispo:SPBC2F12.05c.

Organism-specific databases

EuPathDBiFungiDB:SPBC2F12.05c.
PomBaseiSPBC2F12.05c.

Phylogenomic databases

InParanoidiO14340.
KOiK06867.
OMAiKQPTEGQ.
OrthoDBiEOG7N903T.
PhylomeDBiO14340.

Miscellaneous databases

NextBioi20801485.
PROiO14340.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 3 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384 AND SER-394, IDENTIFICATION BY MASS SPECTROMETRY.
  3. "High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I."
    Rumpf C., Cipak L., Novatchkova M., Li Z., Polakova S., Dudas A., Kovacikova I., Miadokova E., Ammerer G., Gregan J.
    Cell Cycle 9:1802-1808(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH DIL1.

Entry informationi

Entry nameiYB35_SCHPO
AccessioniPrimary (citable) accession number: O14340
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: May 1, 2000
Last modified: January 20, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.