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Protein

DNA-binding protein scr1

Gene

scr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in carbon catabolite repression. Represses the transcription of various genes including the inv1 gene.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 48C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri54 – 78C2H2-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • carbon catabolite repression of transcription from RNA polymerase II promoter by glucose Source: PomBase
  • negative regulation of transcription by RNA polymerase II Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein scr1
Gene namesi
Name:scr1
ORF Names:SPBC1D7.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1D7.02c
PomBaseiSPBC1D7.02c scr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000468851 – 565DNA-binding protein scr1Add BLAST565

Proteomic databases

MaxQBiO14335
PaxDbiO14335
PRIDEiO14335

PTM databases

iPTMnetiO14335

Interactioni

Protein-protein interaction databases

BioGridi277288, 3 interactors
STRINGi4896.SPBC1D7.02c.1

Structurei

3D structure databases

ProteinModelPortaliO14335
SMRiO14335
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi81 – 97Ala-richAdd BLAST17
Compositional biasi164 – 167Poly-Gln4
Compositional biasi375 – 378Poly-Ser4
Compositional biasi509 – 548Ser-richAdd BLAST40

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 48C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri54 – 78C2H2-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoidiO14335
KOiK09467
OrthoDBiEOG092C5XWP

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequencei

Sequence statusi: Complete.

O14335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEATTATTT GKPSRSTKNP DAPRPYKCPL CTKAFYRLEH QTRHIRTHTG
60 70 80 90 100
EKPHVCTFPG CAKRFSRSDE LTRHARIHTN ANSRRNAAAA AAANNSARSS
110 120 130 140 150
NSPAGNLEPS TNNAGVHMTN ASMNPNVNPS YPVFIPQVGM SVAPPVATAA
160 170 180 190 200
VSMSYPHHYS ASVQQQQATF VSNGQPHNLP AQAQPATIYG IPDALHTTQN
210 220 230 240 250
GTTIHVTGTP PGAVSQRSEP DSRLSSMNEM QLLASAAANQ LDAAPRITPT
260 270 280 290 300
KSSGVNLMPL SNAPSPPKQM NVVGSLPSSS NTSPNHLASV PNRGLTSNSS
310 320 330 340 350
TGSFTKYTNG SSNSLYSNSS MQTPYLPSKS NSSTSLHSMY GVGTTAYAPQ
360 370 380 390 400
SLRYAHYNYL PYSRPSVSNG FDDDSSSSDF AHFRYQRRSR PVSPCSTAPS
410 420 430 440 450
SPTFSTRSFS PTPDVTPLVT PAHSPRLRPM DDPSCVQLPS IRSLSLRPSQ
460 470 480 490 500
VPLIPPLKCD PNAFSASTPA SGAVSRTPSS VSLSSLSNVN SSMPHKPASQ
510 520 530 540 550
SNVGPVRISS NRRSRKFSSS SRVSVSNLLA GSPPSPSSST KSASSSYSTT
560
TPAFSIGPLT PMTKP
Length:565
Mass (Da):59,713
Last modified:January 1, 1998 - v1
Checksum:iFE6CCCF7E54A8CDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB10978.1
PIRiT39863
RefSeqiNP_595717.1, NM_001021615.2

Genome annotation databases

EnsemblFungiiSPBC1D7.02c.1; SPBC1D7.02c.1:pep; SPBC1D7.02c
GeneIDi2540768
KEGGispo:SPBC1D7.02c

Similar proteinsi

Entry informationi

Entry nameiSCR1_SCHPO
AccessioniPrimary (citable) accession number: O14335
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health