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Protein

DNA-binding protein scr1

Gene

scr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in carbon catabolite repression. Represses the transcription of various genes including the inv1 gene.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 4823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri54 – 7825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein scr1
Gene namesi
Name:scr1
ORF Names:SPBC1D7.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1D7.02c.
PomBaseiSPBC1D7.02c. scr1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565DNA-binding protein scr1PRO_0000046885Add
BLAST

Proteomic databases

MaxQBiO14335.

Interactioni

Protein-protein interaction databases

BioGridi277288. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliO14335.
SMRiO14335. Positions 29-81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi81 – 9717Ala-richAdd
BLAST
Compositional biasi164 – 1674Poly-Gln
Compositional biasi375 – 3784Poly-Ser
Compositional biasi509 – 54840Ser-richAdd
BLAST

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 4823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri54 – 7825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoidiO14335.
KOiK09467.
OMAiSEYSSAY.
OrthoDBiEOG092C5XWP.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEATTATTT GKPSRSTKNP DAPRPYKCPL CTKAFYRLEH QTRHIRTHTG
60 70 80 90 100
EKPHVCTFPG CAKRFSRSDE LTRHARIHTN ANSRRNAAAA AAANNSARSS
110 120 130 140 150
NSPAGNLEPS TNNAGVHMTN ASMNPNVNPS YPVFIPQVGM SVAPPVATAA
160 170 180 190 200
VSMSYPHHYS ASVQQQQATF VSNGQPHNLP AQAQPATIYG IPDALHTTQN
210 220 230 240 250
GTTIHVTGTP PGAVSQRSEP DSRLSSMNEM QLLASAAANQ LDAAPRITPT
260 270 280 290 300
KSSGVNLMPL SNAPSPPKQM NVVGSLPSSS NTSPNHLASV PNRGLTSNSS
310 320 330 340 350
TGSFTKYTNG SSNSLYSNSS MQTPYLPSKS NSSTSLHSMY GVGTTAYAPQ
360 370 380 390 400
SLRYAHYNYL PYSRPSVSNG FDDDSSSSDF AHFRYQRRSR PVSPCSTAPS
410 420 430 440 450
SPTFSTRSFS PTPDVTPLVT PAHSPRLRPM DDPSCVQLPS IRSLSLRPSQ
460 470 480 490 500
VPLIPPLKCD PNAFSASTPA SGAVSRTPSS VSLSSLSNVN SSMPHKPASQ
510 520 530 540 550
SNVGPVRISS NRRSRKFSSS SRVSVSNLLA GSPPSPSSST KSASSSYSTT
560
TPAFSIGPLT PMTKP
Length:565
Mass (Da):59,713
Last modified:January 1, 1998 - v1
Checksum:iFE6CCCF7E54A8CDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10978.1.
PIRiT39863.
RefSeqiNP_595717.1. NM_001021615.2.

Genome annotation databases

EnsemblFungiiSPBC1D7.02c.1; SPBC1D7.02c.1:pep; SPBC1D7.02c.
GeneIDi2540768.
KEGGispo:SPBC1D7.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAB10978.1.
PIRiT39863.
RefSeqiNP_595717.1. NM_001021615.2.

3D structure databases

ProteinModelPortaliO14335.
SMRiO14335. Positions 29-81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277288. 3 interactions.

Proteomic databases

MaxQBiO14335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1D7.02c.1; SPBC1D7.02c.1:pep; SPBC1D7.02c.
GeneIDi2540768.
KEGGispo:SPBC1D7.02c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1D7.02c.
PomBaseiSPBC1D7.02c. scr1.

Phylogenomic databases

InParanoidiO14335.
KOiK09467.
OMAiSEYSSAY.
OrthoDBiEOG092C5XWP.

Miscellaneous databases

PROiO14335.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCR1_SCHPO
AccessioniPrimary (citable) accession number: O14335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.