Reviewed, UniProtKB/Swiss-Prot O14333 (PSD2_SCHPO)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme 2, mitochondrial
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase 2 beta chain
    2- Recommended name:
            Phosphatidylserine decarboxylase 2 alpha chain

Gene names

ORF Names:

SPBC16E9.18, SPBC1E8.01

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in the regulation of phospholipid biosynthesis and interorganelle trafficking of phosphatidylserine By similarity.
Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.
Subcellular location	Mitochondrion. Ref.2
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from genetic interaction. Source: GeneDB_SPombe regulation of cell morphogenesis Inferred from genetic interaction. Source: GeneDB_SPombe regulation of cytokinesis Inferred from genetic interaction. Source: GeneDB_SPombe
Cellular component	mitochondrion Ref.2 Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	phosphatidylserine decarboxylase activity Inferred from genetic interaction. Source: GeneDB_SPombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 28	28	Mitochondrion Potential
	Chain	29 – 437	409	Phosphatidylserine decarboxylase proenzyme 2, mitochondrial		PRO_0000353844
	Chain	29 – 400	372	Phosphatidylserine decarboxylase 2 beta chain		PRO_0000353845
	Chain	401 – 437	37	Phosphatidylserine decarboxylase 2 alpha chain		PRO_0000353846
Sites
	Site	400 – 401	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	401	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O14333-1 [UniParc]. Last modified August 21, 2007. Version 4. Checksum: 792178F93BDB47DA	FASTA	437	49,129
	10 20 30 40 50 60 MLKFHRNVKP QFGAFARYSS LGKHNSRKRV GIIRLAYGLT GIGLVGLAGF AWAQDRHEKT 70 80 90 100 110 120 YQKKGVQVEG PWQFYVLTTL PLRTLSRWWG YVNRIEIPLW MRVPAFGLYS KIFGCNLTEA 130 140 150 160 170 180 DPDDVRQYKN LAEFFTRKLK PGARVIDPDA PIVIPADGKI LNYGVIEGGQ LEQVKGITYS 190 200 210 220 230 240 LDALLGDEKL ARLKRSHAIP SPDHIPHIRQ EEFAKLNGIH YSLQDLMGHD HGERPSHVKD 250 260 270 280 290 300 ASAQHIDLLS STKVAAKSQF TLFGSRETNC LYYAVIYLAP GDYHRFHSPT DWVVERRRHF 310 320 330 340 350 360 SGELFSVSPF MARRLGNLFI LNERVALMGR YKYGFMSMIP VGATNVGSIR IKFDKDLCTN 370 380 390 400 410 420 QFGKLGPVGT FDEAVYTSSS SILHGHPLLR GDEVGNFELG STVVLVFEAP ADFEFLVKQG 430 QKVRVGLPLG RVVPSSH

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

[2]

"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329671 Genomic DNA. Translation: CAB16910.2.
RefSeq	NP_595799.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O14333.
Genome annotation databases
GeneID	2539756.
KEGG	spo:SPBC16E9.18.
Organism-specific databases
GeneDB_Spombe	SPBC16E9.18.
Gene expression databases
ArrayExpress	O14333.
Family and domain databases
InterPro	IPR003817. PS_Dcarbxylase. IPR005221. PS_decarb. [Graphical view]
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00163. PS_decarb. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD2_SCHPO

Accession

Primary (citable) accession number: O14333
Secondary accession number(s): O42966

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 4, 2008
Last sequence update:	August 21, 2007
Last modified:	October 13, 2009
This is version 51 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)