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O14321

- ERG6_SCHPO

UniProt

O14321 - ERG6_SCHPO

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Protein
Sterol 24-C-methyltransferase erg6
Gene
erg6, SPBC16E9.05
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathwayi

GO - Molecular functioni

  1. sterol 24-C-methyltransferase activity Source: PomBase
Complete GO annotation...

GO - Biological processi

  1. ergosterol biosynthetic process Source: PomBase
  2. protein insertion into membrane raft Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferase erg6 (EC:2.1.1.41)
Alternative name(s):
Delta(24)-sterol C-methyltransferase erg6
Ergosterol biosynthesis protein 6
Gene namesi
Name:erg6
ORF Names:SPBC16E9.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC16E9.05.

Subcellular locationi

Nucleus. Endoplasmic reticulum Inferred 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Sterol 24-C-methyltransferase erg6
PRO_0000124797Add
BLAST

Proteomic databases

MaxQBiO14321.
PaxDbiO14321.

Interactioni

Protein-protein interaction databases

BioGridi276160. 1 interaction.
MINTiMINT-4672270.
STRINGi4896.SPBC16E9.05-1.

Structurei

3D structure databases

ProteinModelPortaliO14321.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0500.
HOGENOMiHOG000171097.
KOiK00559.
OMAiFHFCRFS.
OrthoDBiEOG7DVDMW.
PhylomeDBiO14321.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14321-1 [UniParc]FASTAAdd to Basket

« Hide

MSSTALLPPN TDQVLSRRLH GKAAEKKTGL AAIASKDVDE QSRKLQEYFE    50
FWDRNHENES EEDRARRIDG YKSVVNSYYD LATDLYEYGW SQSFHFSRFY 100
KGEAFAQSIA RHEHYLAYRM GIKPGSRVLD VGCGVGGPAR EITEFTGCNL 150
VGLNNNDYQI SRCNNYAVKR NLDKKQVFVK GDFMHMPFED NTFDYVYAIE 200
ATVHAPSLEG VYGEIFRVLK PGGVFGVYEW VMSDDYDSSI PKHREIAYNI 250
EVGDGIPQMV RKCDAVEAIK KVGFNLLEED DLTDHDNPDL PWYYPLTGDI 300
TKCQNIWDVF TVFRTSRLGK LVTRYSVQFL EKIGVAAKGT SKVGDTLAIA 350
QKGLIEGGET HLFTPMFLMI AKKPETDA 378
Length:378
Mass (Da):42,867
Last modified:January 1, 1998 - v1
Checksum:iFA4D3D82A1CE03D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB16897.1.
D89131 mRNA. Translation: BAA13793.2.
PIRiT39579.
T42375.
RefSeqiNP_595787.1. NM_001021688.2.

Genome annotation databases

EnsemblFungiiSPBC16E9.05.1; SPBC16E9.05.1:pep; SPBC16E9.05.
GeneIDi2539602.
KEGGispo:SPBC16E9.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAB16897.1 .
D89131 mRNA. Translation: BAA13793.2 .
PIRi T39579.
T42375.
RefSeqi NP_595787.1. NM_001021688.2.

3D structure databases

ProteinModelPortali O14321.
ModBasei Search...

Protein-protein interaction databases

BioGridi 276160. 1 interaction.
MINTi MINT-4672270.
STRINGi 4896.SPBC16E9.05-1.

Proteomic databases

MaxQBi O14321.
PaxDbi O14321.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC16E9.05.1 ; SPBC16E9.05.1:pep ; SPBC16E9.05 .
GeneIDi 2539602.
KEGGi spo:SPBC16E9.05.

Organism-specific databases

PomBasei SPBC16E9.05.

Phylogenomic databases

eggNOGi COG0500.
HOGENOMi HOG000171097.
KOi K00559.
OMAi FHFCRFS.
OrthoDBi EOG7DVDMW.
PhylomeDBi O14321.

Enzyme and pathway databases

UniPathwayi UPA00768 ; UER00760 .

Miscellaneous databases

NextBioi 20800759.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view ]
Pfami PF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-378.
    Strain: PR745.
  3. Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 55-63.
  4. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. "Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe."
    Iwaki T., Iefuji H., Hiraga Y., Hosomi A., Morita T., Giga-Hama Y., Takegawa K.
    Microbiology 154:830-841(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiERG6_SCHPO
AccessioniPrimary (citable) accession number: O14321
Secondary accession number(s): P78782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3
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