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Protein

Sterol 24-C-methyltransferase erg6

Gene

erg6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of lanosterol to form eburicol (Probable). Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins (PubMed:18310029).1 Publication1 Publication

Miscellaneous

In S.pombe, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In S.pombe, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + lanosterol = S-adenosyl-L-homocysteine + 24-methylene-24-dihydrolanosterol.1 Publication

Pathwayi: ergosterol biosynthesis

This protein is involved in the pathway ergosterol biosynthesis, which is part of Steroid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway ergosterol biosynthesis and in Steroid metabolism.

GO - Molecular functioni

GO - Biological processi

  • ergosterol biosynthetic process Source: PomBase
  • methylation Source: GO_Central

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00768

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferase erg6 (EC:2.1.1.-)
Alternative name(s):
Delta(24)-sterol C-methyltransferase erg6
Ergosterol biosynthesis protein 6
Gene namesi
Name:erg6
ORF Names:SPBC16E9.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16E9.05
PomBaseiSPBC16E9.05 erg6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001247971 – 378Sterol 24-C-methyltransferase erg6Add BLAST378

Proteomic databases

MaxQBiO14321
PaxDbiO14321
PRIDEiO14321

PTM databases

iPTMnetiO14321

Interactioni

Protein-protein interaction databases

STRINGi4896.SPBC16E9.05.1

Structurei

3D structure databases

ProteinModelPortaliO14321
SMRiO14321
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000171097
InParanoidiO14321
KOiK00559
OMAiGIPKMYK
OrthoDBiEOG092C2LI4
PhylomeDBiO14321

Family and domain databases

InterProiView protein in InterPro
IPR013216 Methyltransf_11
IPR030384 MeTrfase_SMT
IPR029063 SAM-dependent_MTases
IPR013705 Sterol_MeTrfase_C
PfamiView protein in Pfam
PF08241 Methyltransf_11, 1 hit
PF08498 Sterol_MT_C, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits
PROSITEiView protein in PROSITE
PS51685 SAM_MT_ERG6_SMT, 1 hit

Sequencei

Sequence statusi: Complete.

O14321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTALLPPN TDQVLSRRLH GKAAEKKTGL AAIASKDVDE QSRKLQEYFE
60 70 80 90 100
FWDRNHENES EEDRARRIDG YKSVVNSYYD LATDLYEYGW SQSFHFSRFY
110 120 130 140 150
KGEAFAQSIA RHEHYLAYRM GIKPGSRVLD VGCGVGGPAR EITEFTGCNL
160 170 180 190 200
VGLNNNDYQI SRCNNYAVKR NLDKKQVFVK GDFMHMPFED NTFDYVYAIE
210 220 230 240 250
ATVHAPSLEG VYGEIFRVLK PGGVFGVYEW VMSDDYDSSI PKHREIAYNI
260 270 280 290 300
EVGDGIPQMV RKCDAVEAIK KVGFNLLEED DLTDHDNPDL PWYYPLTGDI
310 320 330 340 350
TKCQNIWDVF TVFRTSRLGK LVTRYSVQFL EKIGVAAKGT SKVGDTLAIA
360 370
QKGLIEGGET HLFTPMFLMI AKKPETDA
Length:378
Mass (Da):42,867
Last modified:January 1, 1998 - v1
Checksum:iFA4D3D82A1CE03D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB16897.1
D89131 mRNA Translation: BAA13793.2
PIRiT39579
T42375
RefSeqiNP_595787.1, NM_001021688.2

Genome annotation databases

EnsemblFungiiSPBC16E9.05.1; SPBC16E9.05.1:pep; SPBC16E9.05
GeneIDi2539602
KEGGispo:SPBC16E9.05

Similar proteinsi

Entry informationi

Entry nameiERG6_SCHPO
AccessioniPrimary (citable) accession number: O14321
Secondary accession number(s): P78782
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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