Reviewed, UniProtKB/Swiss-Prot O14313 (PMP20_SCHPO)

Names and origin

Protein names

Recommended name:
    Putative peroxiredoxin pmp20
    EC=1.11.1.15
Alternative name(s):
    Thioredoxin reductase
    Peroxisomal membrane protein pmp20

Gene names

Name:	pmp20
ORF Names:	SPCC330.06c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	156 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
Subcellular location	Peroxisome Potential.
Sequence similarities	Belongs to the peroxiredoxin 2 family. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Peroxisome
Domain	Redox-active center
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro cellular response to stress Inferred by curator. Source: GeneDB_SPombe oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe nucleus Inferred from direct assay. Source: GeneDB_SPombe peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 156	156	Putative peroxiredoxin pmp20		PRO_0000056609
Regions
	Domain	2 – 156	155	Thioredoxin
	Motif	154 – 156	3	Microbody targeting signal By similarity
Experimental info
	Sequence conflict	20	1	E → K in CAA05528. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O14313-1 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: 234DC024251F41D2	FASTA	156	16,675
	10 20 30 40 50 60 MVAVGSTLPK VTLWENKPEE VVEFPSQGKF IIVGVPGAFT PPCSSQVPGY IANEKQFAAK 70 80 90 100 110 120 GISGIYVVAV NDVFVTKAWK KSFDGGEQSG VHFVADWNGE FTKAFDAGFD ASGLLGPLRS 130 140 150 KRYAAVVENG KVVKVFIENE VTDVDISSAD KVLSSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Lenaers G., Perret E., Delpech B., Picard A., Caput D. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 38366 / 972.
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ002536 mRNA. Translation: CAA05528.1. CU329672 Genomic DNA. Translation: CAA20911.1.
PIR	T41316.
RefSeq	NP_587706.1.
3D structure databases
HSSP	HSSP built from PDB template 1NM3 based on UniProtKB P44758.
ModBase	Search...
Genome annotation databases
GeneID	2538981.
KEGG	spo:SPCC330.06c.
NMPDR	fig|4896.1.peg.44.
Organism-specific databases
GeneDB_Spombe	SPCC330.06c.
Phylogenomic databases
OMA	O14313. TCSLAPN.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-002075-MON.
BRENDA	1.11.1.15. 653.
Gene expression databases
ArrayExpress	O14313.
Family and domain databases
InterPro	IPR013740. Redoxin. IPR017936. Thioredoxin-like. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF08534. Redoxin. 1 hit. [Graphical view]
PROSITE	PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PMP20_SCHPO

Accession

Primary (citable) accession number: O14313
Secondary accession number(s): O74877

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	April 27, 2001
Last modified:	June 16, 2009
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)