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Protein

Iron-sulfur clusters transporter atm1, mitochondrial

Gene

atm1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound. Also has an indirect role in vacuolar function where it is required for fluid-phase endocytosis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei401Glutathione; via amide nitrogenBy similarity1
Binding sitei452ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi476 – 487ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

ATP-binding, Iron, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-1369007. Mitochondrial ABC transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur clusters transporter atm1, mitochondrial
Gene namesi
Name:atm1
ORF Names:SPAC15A10.01, SPAC8C9.18
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC15A10.01.
PomBaseiSPAC15A10.01. atm1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 118Mitochondrial matrixBy similarityAdd BLAST90
Transmembranei119 – 140HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini141 – 163Mitochondrial intermembraneBy similarityAdd BLAST23
Transmembranei164 – 187HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini188 – 236Mitochondrial matrixBy similarityAdd BLAST49
Transmembranei237 – 260HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini261Mitochondrial intermembraneBy similarity1
Transmembranei262 – 282HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini283 – 348Mitochondrial matrixBy similarityAdd BLAST66
Transmembranei349 – 367HelicalPROSITE-ProRule annotationAdd BLAST19
Topological domaini368 – 382Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei383 – 404HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini405 – 693Mitochondrial matrixBy similarityAdd BLAST289

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000009346929 – 693Iron-sulfur clusters transporter atm1, mitochondrialAdd BLAST665

Proteomic databases

MaxQBiO14286.
PRIDEiO14286.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-4672006.

Structurei

3D structure databases

ProteinModelPortaliO14286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 409ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST291
Domaini443 – 679ABC transporterPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni288 – 292Glutathione bindingBy similarity5
Regioni351 – 354Glutathione bindingBy similarity4

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO14286.
KOiK05663.
OMAiMMYLAAN.
OrthoDBiEOG092C3H79.
PhylomeDBiO14286.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLERCPWKLI SSPRNIPARS FLNSRGTYLV LRKSNILPLQ HILRFSNFAS
60 70 80 90 100
KQCFPLRNGN NSASKALWNN KSKEKEPLNT SVKLASDVPD DKNVTGQMIV
110 120 130 140 150
KDMLQYIWPK GKTNLKVRVV SALALLVAAK ILNVQVPFYF KSIIDTMNTT
160 170 180 190 200
LVQEVGALWS TVGAVVLGYG FARIFSTVFQ ELRNSVFAIV SQSAIRSVSS
210 220 230 240 250
NVYQHLLNLD MNFHLSKQTG SITRAMDRGT KGISFILSSM VLHIIPITLE
260 270 280 290 300
IAMVSGILTY KYGPSFSAIA ATTVALYALF TVRTTSWRTV FRRQANAADS
310 320 330 340 350
KASAAAIESL INYEAVKTFN NESYEMSRYE KHLSAYEKAN VKVASSLAFL
360 370 380 390 400
NSGQAIIFST ALTLMMYMGC RGIVTSNLTV GDLVMINQLV FQLSIPLNFL
410 420 430 440 450
GSVYREMRQA FTDMEQLFSL KRINIQVKEA PDARDLVLKG GSIQFDNVHF
460 470 480 490 500
SYNPNRPILN GCSFNIPAGA KVAFVGASGC GKSTILRLLF RFYDTDSGKI
510 520 530 540 550
LIDNQRLDQI TLNSLRKAIG VVPQDTPLFN DTILYNIGYG NPKASNDEIV
560 570 580 590 600
EAAKKAKIHD IIESFPEGYQ TKVGERGLMI SGGEKQRLAV SRLLLKNPEI
610 620 630 640 650
LFFDEATSAL DTNTERALLR NINDLIKGSH KTSVFIAHRL RTIKDCDIIF
660 670 680 690
VLEKGRVVEQ GSHEQLMAKN SVYTSMWHSQ ESPFGESNKS GDA
Length:693
Mass (Da):77,056
Last modified:December 15, 1998 - v2
Checksum:iEC493FDEAE90EEFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16305.1.
PIRiT39154.
RefSeqiNP_594288.2. NM_001019711.2.

Genome annotation databases

EnsemblFungiiSPAC15A10.01.1; SPAC15A10.01.1:pep; SPAC15A10.01.
GeneIDi2542779.
KEGGispo:SPAC15A10.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16305.1.
PIRiT39154.
RefSeqiNP_594288.2. NM_001019711.2.

3D structure databases

ProteinModelPortaliO14286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4672006.

Proteomic databases

MaxQBiO14286.
PRIDEiO14286.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC15A10.01.1; SPAC15A10.01.1:pep; SPAC15A10.01.
GeneIDi2542779.
KEGGispo:SPAC15A10.01.

Organism-specific databases

EuPathDBiFungiDB:SPAC15A10.01.
PomBaseiSPAC15A10.01. atm1.

Phylogenomic databases

InParanoidiO14286.
KOiK05663.
OMAiMMYLAAN.
OrthoDBiEOG092C3H79.
PhylomeDBiO14286.

Enzyme and pathway databases

ReactomeiR-SPO-1369007. Mitochondrial ABC transporters.

Miscellaneous databases

PROiO14286.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATM1_SCHPO
AccessioniPrimary (citable) accession number: O14286
Secondary accession number(s): O13721
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: October 5, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.