Reviewed, UniProtKB/Swiss-Prot O14258 (ACE2_SCHPO)

Names and origin

Protein names

Recommended name:
    Metallothionein expression activator

Gene names

Name:	ace2
ORF Names:	SPAC6G10.12c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	533 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Regulates the transcription of genes required for cell separation. Ref.2
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell separation during cytokinesis Ref.2 Inferred from mutant phenotype. Source: GeneDB_SPombe regulation of transcription, mitotic Ref.2 Inferred from genetic interaction. Source: GeneDB_SPombe transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 533	533	Metallothionein expression activator		PRO_0000046799
Regions
	Zinc finger	443 – 472	30	C2H2-type 1
	Zinc finger	473 – 500	28	C2H2-type 2
	Zinc finger	501 – 524	24	C2H2-type 3; atypical

Sequences

	Sequence		Length	Mass (Da)
	O14258-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: A352F632746E7001	FASTA	533	59,842
	10 20 30 40 50 60 MSLSYLSSSS QKSFESFRQE ESPACNHSYQ RDYETFGDSK HTSFSSFAPF ENEVSLNQAV 70 80 90 100 110 120 IPSPPSHLQN FQDQFDYSSV LKTPFNPLLE ANSAYFLSNQ ISLPDSHSYA SSFDASLSPP 130 140 150 160 170 180 SSPLTCVSQI HTEQNFNNND AFSLTNSQQA FSEIGYDASN WIDELDSQQQ VLSFPEFDIP 190 200 210 220 230 240 EIKTETCSNK DHLENFDYLS SSIPETSGPA SSVLPSSSQL ESFNEFMFLP SSPPGLDEIN 250 260 270 280 290 300 GAPSFEELNF QISQPSPAHP VDLSSPETAP NISPVSPFAQ LVKLEPTSPQ KPSFALDSSF 310 320 330 340 350 360 SHLDVCRHTD NQKAFAKLSS PAEYVSEFEK FSSVCDHGLD ISNANINNTL TQQFALSAPY 370 380 390 400 410 420 ESCIVTKKPE PCITVKEEEQ LAPKIESADL SITPQVTEHD SKPPVRISYD HRCKTRKQST 430 440 450 460 470 480 RICRIPPETM ASLYCGPEAD GKYVCLYNGC NKRIARKYNV ESHIQTHLSD RPYRCDLCKA 490 500 510 520 530 GFVRHHDLKR HLRIHENGRP YVCECLKRFN RLDALNRHKQ RNICVGGVDR RQH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.
[2]	"The endo-beta-1,3-glucanase eng1p is required for dissolution of the primary septum during cell separation in Schizosaccharomyces pombe." Martin-Cuadrado A.B., Duenas E., Sipiczki M., de Aldana C.R.V., del Rey F. J. Cell Sci. 116:1689-1698(2003) [PubMed: 12665550] [Abstract] Cited for: IDENTIFICATION, FUNCTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAB11298.1.
PIR	T39062.
RefSeq	NP_594109.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O14258.
Genome annotation databases
GeneID	2541661.
GenomeReviews	Gene locus ace2 in contig CU329670_GR.
KEGG	spo:SPAC6G10.12c.
NMPDR	fig|4896.1.peg.4079.
Organism-specific databases
GeneDB_Spombe	SPAC6G10.12c.
Phylogenomic databases
OrthoDB	EOG9BGBC2
Gene expression databases
ArrayExpress	O14258.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit.
Pfam	PF00096. zf-C2H2. 2 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 2 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 2 hits. PS50157. ZINC_FINGER_C2H2_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACE2_SCHPO

Accession

Primary (citable) accession number: O14258

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
Last sequence update:	January 1, 1998
Last modified:	November 24, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)