Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Metallothionein expression activator

Gene

ace2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regulates the transcription of genes required for cell separation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri443 – 472C2H2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri473 – 500C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri501 – 524C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-2426168. Activation of gene expression by SREBF (SREBP).
R-SPO-3232118. SUMOylation of transcription factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein expression activator
Gene namesi
Name:ace2
ORF Names:SPAC6G10.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC6G10.12c.
PomBaseiSPAC6G10.12c. ace2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000467991 – 533Metallothionein expression activatorAdd BLAST533

Proteomic databases

PRIDEiO14258.

Interactioni

Protein-protein interaction databases

BioGridi278157. 132 interactors.
IntActiO14258. 1 interactor.
MINTiMINT-4782350.

Structurei

3D structure databases

ProteinModelPortaliO14258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri443 – 472C2H2-type 1PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri473 – 500C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri501 – 524C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoidiO14258.
KOiK09238.
OrthoDBiEOG092C2Q0K.
PhylomeDBiO14258.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSYLSSSS QKSFESFRQE ESPACNHSYQ RDYETFGDSK HTSFSSFAPF
60 70 80 90 100
ENEVSLNQAV IPSPPSHLQN FQDQFDYSSV LKTPFNPLLE ANSAYFLSNQ
110 120 130 140 150
ISLPDSHSYA SSFDASLSPP SSPLTCVSQI HTEQNFNNND AFSLTNSQQA
160 170 180 190 200
FSEIGYDASN WIDELDSQQQ VLSFPEFDIP EIKTETCSNK DHLENFDYLS
210 220 230 240 250
SSIPETSGPA SSVLPSSSQL ESFNEFMFLP SSPPGLDEIN GAPSFEELNF
260 270 280 290 300
QISQPSPAHP VDLSSPETAP NISPVSPFAQ LVKLEPTSPQ KPSFALDSSF
310 320 330 340 350
SHLDVCRHTD NQKAFAKLSS PAEYVSEFEK FSSVCDHGLD ISNANINNTL
360 370 380 390 400
TQQFALSAPY ESCIVTKKPE PCITVKEEEQ LAPKIESADL SITPQVTEHD
410 420 430 440 450
SKPPVRISYD HRCKTRKQST RICRIPPETM ASLYCGPEAD GKYVCLYNGC
460 470 480 490 500
NKRIARKYNV ESHIQTHLSD RPYRCDLCKA GFVRHHDLKR HLRIHENGRP
510 520 530
YVCECLKRFN RLDALNRHKQ RNICVGGVDR RQH
Length:533
Mass (Da):59,842
Last modified:January 1, 1998 - v1
Checksum:iA352F632746E7001
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11298.1.
PIRiT39062.
RefSeqiNP_594109.1. NM_001019533.2.

Genome annotation databases

EnsemblFungiiSPAC6G10.12c.1; SPAC6G10.12c.1:pep; SPAC6G10.12c.
GeneIDi2541661.
KEGGispo:SPAC6G10.12c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11298.1.
PIRiT39062.
RefSeqiNP_594109.1. NM_001019533.2.

3D structure databases

ProteinModelPortaliO14258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278157. 132 interactors.
IntActiO14258. 1 interactor.
MINTiMINT-4782350.

Proteomic databases

PRIDEiO14258.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC6G10.12c.1; SPAC6G10.12c.1:pep; SPAC6G10.12c.
GeneIDi2541661.
KEGGispo:SPAC6G10.12c.

Organism-specific databases

EuPathDBiFungiDB:SPAC6G10.12c.
PomBaseiSPAC6G10.12c. ace2.

Phylogenomic databases

InParanoidiO14258.
KOiK09238.
OrthoDBiEOG092C2Q0K.
PhylomeDBiO14258.

Enzyme and pathway databases

ReactomeiR-SPO-2426168. Activation of gene expression by SREBF (SREBP).
R-SPO-3232118. SUMOylation of transcription factors.

Miscellaneous databases

PROiO14258.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACE2_SCHPO
AccessioniPrimary (citable) accession number: O14258
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.