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Reviewed, UniProtKB/Swiss-Prot O14254 (IDHP_SCHPO)

Last modified June 16, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable isocitrate dehydrogenase [NADP], mitochondrial
      Short name=IDH
    EC=1.1.1.42
Alternative name(s):
    Oxalosuccinate decarboxylase
    NADP(+)-specific ICDH
    IDP
Gene names
Name: idp1
ORF Names: SPAC6G10.08
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

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Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Oxalosuccinate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion
Chain? – 418Probable isocitrate dehydrogenase [NADP], mitochondrialPRO_0000014425

Regions

Nucleotide binding85 – 873NADP By similarity
Nucleotide binding320 – 3256NADP By similarity
Region104 – 1107Substrate binding By similarity

Sites

Metal binding2621Magnesium or manganese By similarity
Metal binding2851Magnesium or manganese By similarity
Binding site871Substrate By similarity
Binding site921NADP By similarity
Binding site1191Substrate By similarity
Binding site1421Substrate By similarity
Binding site2701NADP By similarity
Binding site3381NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1491Critical for catalysis By similarity
Site2221Critical for catalysis By similarity

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Sequences

Sequence LengthMass (Da)Tools
O14254-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 6E114B379C8AD61E

FASTA41847,293
        10         20         30         40         50         60 
MNMRMASSKS FQKITVKNPV VEMDGDEMTR VIWKIIREKL VLPYMDIKLD YYDLGIEARD 

        70         80         90        100        110        120 
KTNDQITVDA AKAILKNDVG IKCATITPDE ARVKEYNLKK MWKSPNGTIR NILNGTVFRE 

       130        140        150        160        170        180 
PILIKNIPKY IPGWTNPICI GRHAFGDQYK STDLVASGPG KLELSFTPKG NPSAKETYNV 

       190        200        210        220        230        240 
YEFNGSGVAM SMYNTDDSIR GFAHSSFQMA LQKKMPLYLS TKNTILKKYD GRFKDTFQEV 

       250        260        270        280        290        300 
YESDYKQKFE ELGLWYQHRL IDDMVAQAIK SNGGFVWACK NYDGDVMSDV VAQAYGSLGL 

       310        320        330        340        350        360 
MTSVLIHPNG RTFESEAAHG TVQRHYMQYL KGKKTSTNSI ASIFAWTRGL AHRGRLDGNE 

       370        380        390        400        410 
RLVKFANALE HACVRCVEKG IMTKDLYLLS KSPNGYVDTF EFLDAVKSEL DSELVNIA

« Hide

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References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.

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Cross-references

Sequence databases

CU329670 Genomic DNA. Translation: CAB11294.1.
PIRT39058.
RefSeqNP_594105.1.

3D structure databases

HSSPHSSP built from PDB template 1LWD based on UniProtKB P33198.
ModBaseSearch...

Genome annotation databases

GeneID2542598.
KEGGspo:SPAC6G10.08.
NMPDRfig|4896.1.peg.4075.

Organism-specific databases

GeneDB_SpombeSPAC6G10.08.

Phylogenomic databases

OMAO14254. GGMLWAC.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-001728-MON.
BRENDA1.1.1.42. 653.

Gene expression databases

ArrayExpressO14254.

Family and domain databases

InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004790. Isocitrate_DH_NADP-dep_euk.
[Graphical view]
Gene3DG3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHERPTHR11822. IDH_NADP_euk. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameIDHP_SCHPO
AccessionPrimary (citable) accession number: O14254
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents