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Protein

Probable isocitrate dehydrogenase [NADP], mitochondrial

Gene

idp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108SubstrateBy similarity1
Binding sitei113NADPBy similarity1
Binding sitei140SubstrateBy similarity1
Binding sitei163SubstrateBy similarity1
Sitei170Critical for catalysisBy similarity1
Sitei243Critical for catalysisBy similarity1
Metal bindingi283Magnesium or manganeseBy similarity1
Binding sitei291NADPBy similarity1
Metal bindingi306Magnesium or manganeseBy similarity1
Binding sitei359NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi106 – 108NADPBy similarity3
Nucleotide bindingi341 – 346NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiR-SPO-389542. NADPH regeneration.
R-SPO-6798695. Neutrophil degranulation.
R-SPO-71403. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isocitrate dehydrogenase [NADP], mitochondrial (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:idp1
ORF Names:SPAC6G10.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC6G10.08.
PomBaseiSPAC6G10.08. idp1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionAdd BLAST26
ChainiPRO_000001442527 – 439Probable isocitrate dehydrogenase [NADP], mitochondrialAdd BLAST413

Proteomic databases

MaxQBiO14254.
PRIDEiO14254.

Interactioni

Protein-protein interaction databases

BioGridi279052. 70 interactors.
MINTiMINT-4671801.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 131Substrate bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000019858.
InParanoidiO14254.
KOiK00031.
OrthoDBiEOG092C2D51.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEVRAAVKA PFKLAAAGRG FMNMRMASSK SFQKITVKNP VVEMDGDEMT
60 70 80 90 100
RVIWKIIREK LVLPYMDIKL DYYDLGIEAR DKTNDQITVD AAKAILKNDV
110 120 130 140 150
GIKCATITPD EARVKEYNLK KMWKSPNGTI RNILNGTVFR EPILIKNIPK
160 170 180 190 200
YIPGWTNPIC IGRHAFGDQY KSTDLVASGP GKLELSFTPK GNPSAKETYN
210 220 230 240 250
VYEFNGSGVA MSMYNTDDSI RGFAHSSFQM ALQKKMPLYL STKNTILKKY
260 270 280 290 300
DGRFKDTFQE VYESDYKQKF EELGLWYQHR LIDDMVAQAI KSNGGFVWAC
310 320 330 340 350
KNYDGDVMSD VVAQAYGSLG LMTSVLIHPN GRTFESEAAH GTVQRHYMQY
360 370 380 390 400
LKGKKTSTNS IASIFAWTRG LAHRGRLDGN ERLVKFANAL EHACVRCVEK
410 420 430
GIMTKDLYLL SKSPNGYVDT FEFLDAVKSE LDSELVNIA
Length:439
Mass (Da):49,479
Last modified:April 18, 2012 - v2
Checksum:iCF68839E7C423F5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11294.2.
PIRiT39058.
RefSeqiNP_594105.2. NM_001019529.2.

Genome annotation databases

EnsemblFungiiSPAC6G10.08.1; SPAC6G10.08.1:pep; SPAC6G10.08.
GeneIDi2542598.
KEGGispo:SPAC6G10.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11294.2.
PIRiT39058.
RefSeqiNP_594105.2. NM_001019529.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279052. 70 interactors.
MINTiMINT-4671801.

Proteomic databases

MaxQBiO14254.
PRIDEiO14254.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC6G10.08.1; SPAC6G10.08.1:pep; SPAC6G10.08.
GeneIDi2542598.
KEGGispo:SPAC6G10.08.

Organism-specific databases

EuPathDBiFungiDB:SPAC6G10.08.
PomBaseiSPAC6G10.08. idp1.

Phylogenomic databases

HOGENOMiHOG000019858.
InParanoidiO14254.
KOiK00031.
OrthoDBiEOG092C2D51.

Enzyme and pathway databases

ReactomeiR-SPO-389542. NADPH regeneration.
R-SPO-6798695. Neutrophil degranulation.
R-SPO-71403. Citric acid cycle (TCA cycle).

Miscellaneous databases

PROiO14254.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIDHP_SCHPO
AccessioniPrimary (citable) accession number: O14254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 18, 2012
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.