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Protein

Probable proteasome subunit alpha type-6

Gene

SPAC6G10.04c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-6 (EC:3.4.25.1)
Gene namesi
ORF Names:SPAC6G10.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC6G10.04c.
PomBaseiSPAC6G10.04c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001240751 – 272Probable proteasome subunit alpha type-6Add BLAST272

Proteomic databases

MaxQBiO14250.
PRIDEiO14250.

PTM databases

SwissPalmiO14250.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi279015. 5 interactors.
MINTiMINT-4671764.
STRINGi4896.SPAC6G10.04c.1.

Structurei

3D structure databases

ProteinModelPortaliO14250.
SMRiO14250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000091080.
InParanoidiO14250.
KOiK02725.
OMAiFMKQQCL.
OrthoDBiEOG092C47D8.
PhylomeDBiO14250.

Family and domain databases

CDDicd03749. proteasome_alpha_type_1. 1 hit.
Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR035144. Proteasome_alpha1.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
PANTHERiPTHR11599:SF93. PTHR11599:SF93. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O14250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRNQYDGDA TTWSPQGRLH QVEYALEAIK QGSATVGLVS KTHAVLVALK
60 70 80 90 100
RNAEELSSYQ KKLIRIDDHI GIAIAGLAPD ARVLSNYMKQ EALSSKTLFT
110 120 130 140 150
RPIPVRRLMS KVAEKAQINT QEYGRRPYGV GFLVIGYDES GPHLLEFQPS
160 170 180 190 200
GLVLEYLGTS MGSRSQSART YIERNLDTFP DSSREELILS ALRALRDTLS
210 220 230 240 250
KDQELTEENV SISVIGKDEK YTLYDQNDTK EWLDKLGDKG PAAARASRAA
260 270
AEEPQAPTAE AILDSADAME TD
Length:272
Mass (Da):30,111
Last modified:January 1, 1998 - v1
Checksum:iB8F8930F03F03E28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11290.1.
PIRiT39054.
RefSeqiNP_594101.1. NM_001019525.2.

Genome annotation databases

EnsemblFungiiSPAC6G10.04c.1; SPAC6G10.04c.1:pep; SPAC6G10.04c.
GeneIDi2542559.
KEGGispo:SPAC6G10.04c.

Similar proteinsi

Entry informationi

Entry nameiPSA6_SCHPO
AccessioniPrimary (citable) accession number: O14250
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: January 1, 1998
Last modified: September 27, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families