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O14250

- PSA6_SCHPO

UniProt

O14250 - PSA6_SCHPO

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Protein

Probable proteasome subunit alpha type-6

Gene

SPAC6G10.04c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteasome-mediated ubiquitin-dependent protein catabolic process Source: PomBase
  2. regulation of mitotic cell cycle Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_188524. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_188566. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_188568. ER-Phagosome pathway.
REACT_188587. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_208775. SCF-beta-TrCP mediated degradation of Emi1.
REACT_215140. CDK-mediated phosphorylation and removal of Cdc6.
REACT_215320. Orc1 removal from chromatin.
REACT_218991. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_81558. Regulation of activated PAK-2p34 by proteasome mediated degradation.

Protein family/group databases

MEROPSiT01.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-6 (EC:3.4.25.1)
Gene namesi
ORF Names:SPAC6G10.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC6G10.04c.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
  3. proteasome core complex, alpha-subunit complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Probable proteasome subunit alpha type-6PRO_0000124075Add
BLAST

Proteomic databases

MaxQBiO14250.
PaxDbiO14250.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi279015. 7 interactions.
MINTiMINT-4671764.
STRINGi4896.SPAC6G10.04c-1.

Structurei

3D structure databases

ProteinModelPortaliO14250.
SMRiO14250. Positions 1-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000091080.
InParanoidiO14250.
KOiK02725.
OMAiFMKQQCL.
OrthoDBiEOG7SBP0C.
PhylomeDBiO14250.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14250-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRNQYDGDA TTWSPQGRLH QVEYALEAIK QGSATVGLVS KTHAVLVALK
60 70 80 90 100
RNAEELSSYQ KKLIRIDDHI GIAIAGLAPD ARVLSNYMKQ EALSSKTLFT
110 120 130 140 150
RPIPVRRLMS KVAEKAQINT QEYGRRPYGV GFLVIGYDES GPHLLEFQPS
160 170 180 190 200
GLVLEYLGTS MGSRSQSART YIERNLDTFP DSSREELILS ALRALRDTLS
210 220 230 240 250
KDQELTEENV SISVIGKDEK YTLYDQNDTK EWLDKLGDKG PAAARASRAA
260 270
AEEPQAPTAE AILDSADAME TD
Length:272
Mass (Da):30,111
Last modified:January 1, 1998 - v1
Checksum:iB8F8930F03F03E28
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11290.1.
PIRiT39054.
RefSeqiNP_594101.1. NM_001019525.2.

Genome annotation databases

EnsemblFungiiSPAC6G10.04c.1; SPAC6G10.04c.1:pep; SPAC6G10.04c.
GeneIDi2542559.
KEGGispo:SPAC6G10.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11290.1 .
PIRi T39054.
RefSeqi NP_594101.1. NM_001019525.2.

3D structure databases

ProteinModelPortali O14250.
SMRi O14250. Positions 1-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279015. 7 interactions.
MINTi MINT-4671764.
STRINGi 4896.SPAC6G10.04c-1.

Protein family/group databases

MEROPSi T01.976.

Proteomic databases

MaxQBi O14250.
PaxDbi O14250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC6G10.04c.1 ; SPAC6G10.04c.1:pep ; SPAC6G10.04c .
GeneIDi 2542559.
KEGGi spo:SPAC6G10.04c.

Organism-specific databases

PomBasei SPAC6G10.04c.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000091080.
InParanoidi O14250.
KOi K02725.
OMAi FMKQQCL.
OrthoDBi EOG7SBP0C.
PhylomeDBi O14250.

Enzyme and pathway databases

Reactomei REACT_188524. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_188566. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_188568. ER-Phagosome pathway.
REACT_188587. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_208775. SCF-beta-TrCP mediated degradation of Emi1.
REACT_215140. CDK-mediated phosphorylation and removal of Cdc6.
REACT_215320. Orc1 removal from chromatin.
REACT_218991. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
REACT_81558. Regulation of activated PAK-2p34 by proteasome mediated degradation.

Miscellaneous databases

NextBioi 20803610.
PROi O14250.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPSA6_SCHPO
AccessioniPrimary (citable) accession number: O14250
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3