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Protein

Nucleolar GTP-binding protein 2

Gene

nog2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi317 – 324GTPSequence analysis8
Nucleotide bindingi361 – 365GTPSequence analysis5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 2
Gene namesi
Name:nog2
ORF Names:SPAC6F6.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC6F6.03c.
PomBaseiSPAC6F6.03c. nog2.

Subcellular locationi

GO - Cellular componenti

  • mitotic spindle Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nucleolus Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002158151 – 537Nucleolar GTP-binding protein 2Add BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186Phosphoserine1 Publication1
Modified residuei484Phosphothreonine1 Publication1
Modified residuei487Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14236.
PRIDEiO14236.

PTM databases

iPTMnetiO14236.

Interactioni

Protein-protein interaction databases

BioGridi279226. 7 interactors.
MINTiMINT-4671652.

Structurei

3D structure databases

ProteinModelPortaliO14236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 368CP-type GPROSITE-ProRule annotationAdd BLAST162

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.PROSITE-ProRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000189714.
InParanoidiO14236.
KOiK14537.
OMAiYIPAVLE.
OrthoDBiEOG092C2X6U.
PhylomeDBiO14236.

Family and domain databases

Gene3Di1.10.1580.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR023179. GTP-bd_ortho_bundle.
IPR006073. GTP_binding_domain.
IPR024929. NOG2.
IPR012971. NOG2_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11089:SF9. PTHR11089:SF9. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
PF08153. NGP1NT. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTYKKEKSR IGREGANEKK PGNLRVKGEN FYRNAKDVAR VNMYRGGKAK
60 70 80 90 100
YNAAGELVRA AEFQSSEVPK ARIQPDRRWF NNTRVIAQPT LTQFREAMGQ
110 120 130 140 150
KLNDPYQVLL RRNKLPMSLL QENTEIPKVR VLESEPFENT FGPKSQRKRP
160 170 180 190 200
KISFDSVAEL AKESDEKQNA YEEKIEERIL ANPDESDDVM LAARDAIFSK
210 220 230 240 250
GQSKRIWNEL YKVIDSSDVL IQVLDARDPV GTRCGTVERY LRNEASHKHM
260 270 280 290 300
ILVLNKVDLV PTSVAAAWVK ILAKEYPTIA FHASINNSFG KGSLIQILRQ
310 320 330 340 350
FASLHSDKKQ ISVGLIGFPN AGKSSIINTL RKKKVCNVAP IPGETKVWQY
360 370 380 390 400
VALMKRIFLI DCPGIVPPSS NDSDAELLLK GVVRVENVSN PEAYIPTVLS
410 420 430 440 450
RCKVKHLERT YEISGWNDST EFLAKLAKKG GRLLKGGEPD EASVAKMVLN
460 470 480 490 500
DFMRGKIPWF IGPKGLSSSN DEINSSQKVA TQQTEGSDQD GEEAEEEWHG
510 520 530
ISDDGKADES ESTKPVAEGS ASESTDESAV DDNKNRS
Length:537
Mass (Da):59,914
Last modified:January 1, 1998 - v1
Checksum:i425F4F38949AF964
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11727.1.
AB028005 Genomic DNA. Translation: BAA87309.1.
PIRiT39037.
RefSeqiNP_593896.1. NM_001019326.2.

Genome annotation databases

EnsemblFungiiSPAC6F6.03c.1; SPAC6F6.03c.1:pep; SPAC6F6.03c.
GeneIDi2542777.
KEGGispo:SPAC6F6.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11727.1.
AB028005 Genomic DNA. Translation: BAA87309.1.
PIRiT39037.
RefSeqiNP_593896.1. NM_001019326.2.

3D structure databases

ProteinModelPortaliO14236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279226. 7 interactors.
MINTiMINT-4671652.

PTM databases

iPTMnetiO14236.

Proteomic databases

MaxQBiO14236.
PRIDEiO14236.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC6F6.03c.1; SPAC6F6.03c.1:pep; SPAC6F6.03c.
GeneIDi2542777.
KEGGispo:SPAC6F6.03c.

Organism-specific databases

EuPathDBiFungiDB:SPAC6F6.03c.
PomBaseiSPAC6F6.03c. nog2.

Phylogenomic databases

HOGENOMiHOG000189714.
InParanoidiO14236.
KOiK14537.
OMAiYIPAVLE.
OrthoDBiEOG092C2X6U.
PhylomeDBiO14236.

Miscellaneous databases

PROiO14236.

Family and domain databases

Gene3Di1.10.1580.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR030378. G_CP_dom.
IPR023179. GTP-bd_ortho_bundle.
IPR006073. GTP_binding_domain.
IPR024929. NOG2.
IPR012971. NOG2_N_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11089:SF9. PTHR11089:SF9. 1 hit.
PfamiPF01926. MMR_HSR1. 1 hit.
PF08153. NGP1NT. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNOG2_SCHPO
AccessioniPrimary (citable) accession number: O14236
Secondary accession number(s): Q9US70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.