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O14234 (CCH1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium-channel protein cch1
Gene names
Name:cch1
ORF Names:SPAC6F6.01
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length1854 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Voltage-gated, high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones. Functions together with yam8 to ensure that adequate levels of Ca2+ are supplied to pmr1 to sustain secretion and growth. Required for growth in low-calcium environments By similarity.

Subunit structure

Interacts with yam8 to form a Ca2+ influx channel By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein Potential Ref.2.

Sequence similarities

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18541854Calcium-channel protein cch1
PRO_0000311769

Regions

Transmembrane184 – 20421Helical; Potential
Transmembrane220 – 24021Helical; Potential
Transmembrane274 – 29421Helical; Potential
Transmembrane328 – 34821Helical; Potential
Transmembrane427 – 44721Helical; Potential
Transmembrane461 – 48121Helical; Potential
Transmembrane514 – 53421Helical; Potential
Transmembrane549 – 56921Helical; Potential
Transmembrane581 – 60121Helical; Potential
Transmembrane606 – 62621Helical; Potential
Transmembrane642 – 66221Helical; Potential
Transmembrane723 – 74321Helical; Potential
Transmembrane946 – 96621Helical; Potential
Transmembrane980 – 100021Helical; Potential
Transmembrane1021 – 104121Helical; Potential
Transmembrane1075 – 109521Helical; Potential
Transmembrane1148 – 116821Helical; Potential
Transmembrane1193 – 121321Helical; Potential
Transmembrane1274 – 129421Helical; Potential
Transmembrane1302 – 132221Helical; Potential
Transmembrane1331 – 135121Helical; Potential
Transmembrane1358 – 137821Helical; Potential
Transmembrane1393 – 141321Helical; Potential
Transmembrane1486 – 150621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O14234 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 79C972D54E228DFA

FASTA1,854213,165
        10         20         30         40         50         60 
MSSSSNSDPS SSPDNTDFIP LKDNPKDTSS YINKKNPFVN DSFDSHDDSY LDNVNPFEYN 

        70         80         90        100        110        120 
VADDEDTISM TSDGVEFHNL GITETVDEQD KILSELQLAY PTVSRYSETL DKGLLNGDKT 

       130        140        150        160        170        180 
TKGDYTSLRR FRKPFLFDKL SPYFTHFFSE IYAAVLRVVG PPRANETPGR NLPFSPILRQ 

       190        200        210        220        230        240 
IYNHPLYNIF IFVVIVLHAV LLMIRSDDPH DKSQTIDYLI IVIGILYTLE MLLKIYLFGF 

       250        260        270        280        290        300 
LYDGSSSFYD FINSYTKKTP RTMSYLRHSW NRVDFVAIVA LWISVIGKKQ QGIFRLFSMI 

       310        320        330        340        350        360 
ACLRLTRLLN ITRKTETILK SLKESSTPLV QVVSFNAFFG VMIAILGVQF FKASLNRQCV 

       370        380        390        400        410        420 
WLGDYGDQYL PTGQFCGGHW ENGIKRAYLD KNGFPSNVNP RGFICAEKSV CRVVENPYSN 

       430        440        450        460        470        480 
TVSFDNFFNS LELIFVIMSS NGFTDIMYDI MDAEYFVSCL LFIISAYFLT LWLMSLVIAV 

       490        500        510        520        530        540 
VTSSFIDLQH SGKNQKEQKS VDKHLIRNKL CEKYLFYSNF IWISFIVAQF VTLCTQTYDQ 

       550        560        570        580        590        600 
TSSTANRYLI FYACVDFLLA AEVILRFFAY LPDYRLFFRR YTNLVDIVLA VLNLVTLLPS 

       610        620        630        640        650        660 
IRKNPVAFGW LSIFAIARIY RCILLIPYTR KIAKLLFSNF KQLLNLMLFL VIVLFIASLC 

       670        680        690        700        710        720 
AVRLFQDLPN DGDSDDDAIS FATTYESFLY MYQILTSENW TDVMFAIQAR LAHLHLSWIP 

       730        740        750        760        770        780 
GAFFTLWFLF SNNVVLSMFI AVIQVNFAPS ESDLKMEQLK MYLARLLRNY NPFQASLTLN 

       790        800        810        820        830        840 
ALIKRNGSRK GKTVDESHYE WLYEDNIIKG FLRVTNIPPK EPLKPSLDTS PELSKYSLAK 

       850        860        870        880        890        900 
LSNNFKRFVM RDDPFSQAYF KRVIGIRWEK DMNLKTAAKD MQAAKAFVRI KQTEFLKNHP 

       910        920        930        940        950        960 
KYNDVFWVIK PSNRIRRFCQ RLVMPGVNER YGGVEPYQWV YRVIQVFIYA CILTAVIIEC 

       970        980        990       1000       1010       1020 
IATPIYERDH LLNDKQHAWF VWTEVAFATI FTIEAAIKII ADGFCITPNA YLRSTWNCID 

      1030       1040       1050       1060       1070       1080 
FFVLVTLWIN LYAVLTSHAL LSRAFRAFKA LRVLRLINLT QTSQRMFHDA LISGFFKIFS 

      1090       1100       1110       1120       1130       1140 
AAVVSATLLI PFALWAKNVF GGLLYSCNDD NVLSASQCVL EYASTPNNWE VWAPRVWSNP 

      1150       1160       1170       1180       1190       1200 
PDYDFDRFPH ALLALFEIAS IEGWVDIMRS VMDITGFNNQ PQTNASSGNA MFFVLFNLVS 

      1210       1220       1230       1240       1250       1260 
MIYILTLFIA IIISNYAERT GSAFFTAEQR AWLELRRKIK SMRPSKRPAI RPLGLRGLCY 

      1270       1280       1290       1300       1310       1320 
DFAVQKHGIW RRTFTGLYIV HLLFLLTIFY PCPIAYTYVR NSIFLILSIC YTINICVKVY 

      1330       1340       1350       1360       1370       1380 
GLSFYYFFHS FWNMFDVVVT LGSLTCNIAI LAKFENRSLT LLQTTLLVLV TVHLIPKFDN 

      1390       1400       1410       1420       1430       1440 
FDQLSKTVVA SLPSIFSLIA TWIVLYITFA IAFNQIFGLT KLGLNGGPNK NFRSIRNALV 

      1450       1460       1470       1480       1490       1500 
LLFTMTFGEG WNDVMHDYTI SYPNCVNGDD FYNSDCGNKP WAYGLFIAWN IISMYIFVNM 

      1510       1520       1530       1540       1550       1560 
FITVVFDNFS YIHTKSSSFT NLQRNDFRQF KDSWAPFDPM VTGYIPKRNA VKFVLSLRGV 

      1570       1580       1590       1600       1610       1620 
YDFRIYRDEH TLRSIISKVQ SKTGQQSVPM LENPLMGSEI NLEALDQIID TIDVNVVKER 

      1630       1640       1650       1660       1670       1680 
RNVLNSLCTE IMTLPGNVIS FSNILMLVVL HKIVDHREAF PISDYIRRAY VLSELEKSIR 

      1690       1700       1710       1720       1730       1740 
MEKLLGLVET SIIRKTFLQH MEEKKKALEN PFILLSEVSE ILPETPIQEV LRQHNADPEQ 

      1750       1760       1770       1780       1790       1800 
LLMSTRTPSV SDRSFSIVES TVPTIASGEG DDNHSVEDHL KVPTDNEPRR SPSLKEVLLR 

      1810       1820       1830       1840       1850 
GSHSLHSNND RTSFDIEAGF GTAESDFQFG GATEDINRIA DRIDDYLDRD SFKG

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329670 Genomic DNA. Translation: CAB11726.1.
PIRT39035.
RefSeqNP_593894.1. NM_001019324.2.

3D structure databases

ProteinModelPortalO14234.
ModBaseSearch...

Protein-protein interaction databases

STRING4896.SPAC6F6.01-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC6F6.01.1; SPAC6F6.01.1:pep; SPAC6F6.01.
GeneID2542812.
KEGGspo:SPAC6F6.01.

Organism-specific databases

PomBaseSPAC6F6.01.

Phylogenomic databases

eggNOGNOG268129.
OMALALVEWK.
OrthoDBEOG4B5SD9.

Family and domain databases

InterProIPR005821. Ion_trans_dom.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSPR00167. CACHANNEL.
ProtoNetSearch...

Other

NextBio20803854.

Entry information

Entry nameCCH1_SCHPO
AccessionPrimary (citable) accession number: O14234
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 1, 1998
Last modified: May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents