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O14234

- CCH1_SCHPO

UniProt

O14234 - CCH1_SCHPO

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Protein

Calcium-channel protein cch1

Gene

cch1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Voltage-gated, high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones. Functions together with yam8 to ensure that adequate levels of Ca2+ are supplied to pmr1 to sustain secretion and growth. Required for growth in low-calcium environments (By similarity).By similarity

GO - Molecular functioni

  1. calcium channel activity Source: PomBase
  2. voltage-gated calcium channel activity Source: InterPro

GO - Biological processi

  1. positive regulation of calcium-mediated signaling Source: PomBase
  2. positive regulation of phosphoprotein phosphatase activity Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Protein family/group databases

TCDBi1.A.1.11.23. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-channel protein cch1
Gene namesi
Name:cch1
ORF Names:SPAC6F6.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC6F6.01.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
  2. integral component of plasma membrane Source: PomBase
  3. voltage-gated calcium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18541854Calcium-channel protein cch1PRO_0000311769Add
BLAST

Proteomic databases

MaxQBiO14234.

Interactioni

Subunit structurei

Interacts with yam8 to form a Ca2+ influx channel.By similarity

Protein-protein interaction databases

BioGridi279259. 33 interactions.
MINTiMINT-4671635.
STRINGi4896.SPAC6F6.01-1.

Structurei

3D structure databases

ProteinModelPortaliO14234.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei184 – 20421HelicalSequence AnalysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Transmembranei328 – 34821HelicalSequence AnalysisAdd
BLAST
Transmembranei427 – 44721HelicalSequence AnalysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence AnalysisAdd
BLAST
Transmembranei514 – 53421HelicalSequence AnalysisAdd
BLAST
Transmembranei549 – 56921HelicalSequence AnalysisAdd
BLAST
Transmembranei581 – 60121HelicalSequence AnalysisAdd
BLAST
Transmembranei606 – 62621HelicalSequence AnalysisAdd
BLAST
Transmembranei642 – 66221HelicalSequence AnalysisAdd
BLAST
Transmembranei723 – 74321HelicalSequence AnalysisAdd
BLAST
Transmembranei946 – 96621HelicalSequence AnalysisAdd
BLAST
Transmembranei980 – 100021HelicalSequence AnalysisAdd
BLAST
Transmembranei1021 – 104121HelicalSequence AnalysisAdd
BLAST
Transmembranei1075 – 109521HelicalSequence AnalysisAdd
BLAST
Transmembranei1148 – 116821HelicalSequence AnalysisAdd
BLAST
Transmembranei1193 – 121321HelicalSequence AnalysisAdd
BLAST
Transmembranei1274 – 129421HelicalSequence AnalysisAdd
BLAST
Transmembranei1302 – 132221HelicalSequence AnalysisAdd
BLAST
Transmembranei1331 – 135121HelicalSequence AnalysisAdd
BLAST
Transmembranei1358 – 137821HelicalSequence AnalysisAdd
BLAST
Transmembranei1393 – 141321HelicalSequence AnalysisAdd
BLAST
Transmembranei1486 – 150621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268129.
InParanoidiO14234.
OMAiLALVEWK.
OrthoDBiEOG7Z69MN.
PhylomeDBiO14234.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.

Sequencei

Sequence statusi: Complete.

O14234-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSSSNSDPS SSPDNTDFIP LKDNPKDTSS YINKKNPFVN DSFDSHDDSY
60 70 80 90 100
LDNVNPFEYN VADDEDTISM TSDGVEFHNL GITETVDEQD KILSELQLAY
110 120 130 140 150
PTVSRYSETL DKGLLNGDKT TKGDYTSLRR FRKPFLFDKL SPYFTHFFSE
160 170 180 190 200
IYAAVLRVVG PPRANETPGR NLPFSPILRQ IYNHPLYNIF IFVVIVLHAV
210 220 230 240 250
LLMIRSDDPH DKSQTIDYLI IVIGILYTLE MLLKIYLFGF LYDGSSSFYD
260 270 280 290 300
FINSYTKKTP RTMSYLRHSW NRVDFVAIVA LWISVIGKKQ QGIFRLFSMI
310 320 330 340 350
ACLRLTRLLN ITRKTETILK SLKESSTPLV QVVSFNAFFG VMIAILGVQF
360 370 380 390 400
FKASLNRQCV WLGDYGDQYL PTGQFCGGHW ENGIKRAYLD KNGFPSNVNP
410 420 430 440 450
RGFICAEKSV CRVVENPYSN TVSFDNFFNS LELIFVIMSS NGFTDIMYDI
460 470 480 490 500
MDAEYFVSCL LFIISAYFLT LWLMSLVIAV VTSSFIDLQH SGKNQKEQKS
510 520 530 540 550
VDKHLIRNKL CEKYLFYSNF IWISFIVAQF VTLCTQTYDQ TSSTANRYLI
560 570 580 590 600
FYACVDFLLA AEVILRFFAY LPDYRLFFRR YTNLVDIVLA VLNLVTLLPS
610 620 630 640 650
IRKNPVAFGW LSIFAIARIY RCILLIPYTR KIAKLLFSNF KQLLNLMLFL
660 670 680 690 700
VIVLFIASLC AVRLFQDLPN DGDSDDDAIS FATTYESFLY MYQILTSENW
710 720 730 740 750
TDVMFAIQAR LAHLHLSWIP GAFFTLWFLF SNNVVLSMFI AVIQVNFAPS
760 770 780 790 800
ESDLKMEQLK MYLARLLRNY NPFQASLTLN ALIKRNGSRK GKTVDESHYE
810 820 830 840 850
WLYEDNIIKG FLRVTNIPPK EPLKPSLDTS PELSKYSLAK LSNNFKRFVM
860 870 880 890 900
RDDPFSQAYF KRVIGIRWEK DMNLKTAAKD MQAAKAFVRI KQTEFLKNHP
910 920 930 940 950
KYNDVFWVIK PSNRIRRFCQ RLVMPGVNER YGGVEPYQWV YRVIQVFIYA
960 970 980 990 1000
CILTAVIIEC IATPIYERDH LLNDKQHAWF VWTEVAFATI FTIEAAIKII
1010 1020 1030 1040 1050
ADGFCITPNA YLRSTWNCID FFVLVTLWIN LYAVLTSHAL LSRAFRAFKA
1060 1070 1080 1090 1100
LRVLRLINLT QTSQRMFHDA LISGFFKIFS AAVVSATLLI PFALWAKNVF
1110 1120 1130 1140 1150
GGLLYSCNDD NVLSASQCVL EYASTPNNWE VWAPRVWSNP PDYDFDRFPH
1160 1170 1180 1190 1200
ALLALFEIAS IEGWVDIMRS VMDITGFNNQ PQTNASSGNA MFFVLFNLVS
1210 1220 1230 1240 1250
MIYILTLFIA IIISNYAERT GSAFFTAEQR AWLELRRKIK SMRPSKRPAI
1260 1270 1280 1290 1300
RPLGLRGLCY DFAVQKHGIW RRTFTGLYIV HLLFLLTIFY PCPIAYTYVR
1310 1320 1330 1340 1350
NSIFLILSIC YTINICVKVY GLSFYYFFHS FWNMFDVVVT LGSLTCNIAI
1360 1370 1380 1390 1400
LAKFENRSLT LLQTTLLVLV TVHLIPKFDN FDQLSKTVVA SLPSIFSLIA
1410 1420 1430 1440 1450
TWIVLYITFA IAFNQIFGLT KLGLNGGPNK NFRSIRNALV LLFTMTFGEG
1460 1470 1480 1490 1500
WNDVMHDYTI SYPNCVNGDD FYNSDCGNKP WAYGLFIAWN IISMYIFVNM
1510 1520 1530 1540 1550
FITVVFDNFS YIHTKSSSFT NLQRNDFRQF KDSWAPFDPM VTGYIPKRNA
1560 1570 1580 1590 1600
VKFVLSLRGV YDFRIYRDEH TLRSIISKVQ SKTGQQSVPM LENPLMGSEI
1610 1620 1630 1640 1650
NLEALDQIID TIDVNVVKER RNVLNSLCTE IMTLPGNVIS FSNILMLVVL
1660 1670 1680 1690 1700
HKIVDHREAF PISDYIRRAY VLSELEKSIR MEKLLGLVET SIIRKTFLQH
1710 1720 1730 1740 1750
MEEKKKALEN PFILLSEVSE ILPETPIQEV LRQHNADPEQ LLMSTRTPSV
1760 1770 1780 1790 1800
SDRSFSIVES TVPTIASGEG DDNHSVEDHL KVPTDNEPRR SPSLKEVLLR
1810 1820 1830 1840 1850
GSHSLHSNND RTSFDIEAGF GTAESDFQFG GATEDINRIA DRIDDYLDRD

SFKG
Length:1,854
Mass (Da):213,165
Last modified:January 1, 1998 - v1
Checksum:i79C972D54E228DFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11726.1.
PIRiT39035.
RefSeqiNP_593894.1. NM_001019324.2.

Genome annotation databases

EnsemblFungiiSPAC6F6.01.1; SPAC6F6.01.1:pep; SPAC6F6.01.
GeneIDi2542812.
KEGGispo:SPAC6F6.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB11726.1 .
PIRi T39035.
RefSeqi NP_593894.1. NM_001019324.2.

3D structure databases

ProteinModelPortali O14234.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279259. 33 interactions.
MINTi MINT-4671635.
STRINGi 4896.SPAC6F6.01-1.

Protein family/group databases

TCDBi 1.A.1.11.23. the voltage-gated ion channel (vic) superfamily.

Proteomic databases

MaxQBi O14234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC6F6.01.1 ; SPAC6F6.01.1:pep ; SPAC6F6.01 .
GeneIDi 2542812.
KEGGi spo:SPAC6F6.01.

Organism-specific databases

PomBasei SPAC6F6.01.

Phylogenomic databases

eggNOGi NOG268129.
InParanoidi O14234.
OMAi LALVEWK.
OrthoDBi EOG7Z69MN.
PhylomeDBi O14234.

Miscellaneous databases

NextBioi 20803854.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCH1_SCHPO
AccessioniPrimary (citable) accession number: O14234
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3