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Protein

Rho GDP-dissociation inhibitor

Gene

SPAC6F12.06

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-SPO-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GDP-dissociation inhibitor
Short name:
Rho GDI
Gene namesi
ORF Names:SPAC6F12.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC6F12.06.
PomBaseiSPAC6F12.06.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Rho GDP-dissociation inhibitorPRO_0000318108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14224.

PTM databases

iPTMnetiO14224.

Interactioni

Protein-protein interaction databases

BioGridi279643. 10 interactions.
MINTiMINT-4671533.

Structurei

3D structure databases

ProteinModelPortaliO14224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho GDI family.Curated

Phylogenomic databases

HOGENOMiHOG000175765.
InParanoidiO14224.
KOiK12462.
OMAiTMDSPGR.
OrthoDBiEOG092C4OKG.
PhylomeDBiO14224.

Family and domain databases

Gene3Di2.70.50.30. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
[Graphical view]
PANTHERiPTHR10980. PTHR10980. 1 hit.
PfamiPF02115. Rho_GDI. 1 hit.
[Graphical view]
PRINTSiPR00492. RHOGDI.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

O14224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVNNEVSAD QHNPELEDDT FEHGPPVSLG EKKSLNEYMK MDAEDESLQK
60 70 80 90 100
WKASLGITGT GYSPSNDRRT VVILKLSLLV DGRDPVDVNM EDAASVEQIR
110 120 130 140 150
KKGFTIKEGS EFKIGVKFRV QHEVISGLRY VQTVRRRGFV VDKTSTMIGS
160 170 180 190 200
YGPSETPYDF TSEPDEAPTG MLARGHYEAN GKFVDDDKVV HHEFVWAFDV

AKSWK
Length:205
Mass (Da):23,032
Last modified:January 1, 1998 - v1
Checksum:i4CD754164E6A74E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11090.1.
PIRiT11657.
RefSeqiNP_593292.1. NM_001018722.2.

Genome annotation databases

EnsemblFungiiSPAC6F12.06.1; SPAC6F12.06.1:pep; SPAC6F12.06.
GeneIDi2543214.
KEGGispo:SPAC6F12.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11090.1.
PIRiT11657.
RefSeqiNP_593292.1. NM_001018722.2.

3D structure databases

ProteinModelPortaliO14224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279643. 10 interactions.
MINTiMINT-4671533.

PTM databases

iPTMnetiO14224.

Proteomic databases

MaxQBiO14224.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC6F12.06.1; SPAC6F12.06.1:pep; SPAC6F12.06.
GeneIDi2543214.
KEGGispo:SPAC6F12.06.

Organism-specific databases

EuPathDBiFungiDB:SPAC6F12.06.
PomBaseiSPAC6F12.06.

Phylogenomic databases

HOGENOMiHOG000175765.
InParanoidiO14224.
KOiK12462.
OMAiTMDSPGR.
OrthoDBiEOG092C4OKG.
PhylomeDBiO14224.

Enzyme and pathway databases

ReactomeiR-SPO-194840. Rho GTPase cycle.

Miscellaneous databases

PROiO14224.

Family and domain databases

Gene3Di2.70.50.30. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR000406. Rho_GDI.
IPR024792. RhoGDI_domain.
[Graphical view]
PANTHERiPTHR10980. PTHR10980. 1 hit.
PfamiPF02115. Rho_GDI. 1 hit.
[Graphical view]
PRINTSiPR00492. RHOGDI.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGDIR_SCHPO
AccessioniPrimary (citable) accession number: O14224
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.