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Protein

Aromatic amino acid aminotransferase C56E4.03

Gene

SPAC56E4.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has aromatic amino acid transaminase activity.By similarity

Catalytic activityi

An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-SPO-71064. Lysine catabolism.
R-SPO-71240. Tryptophan catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatic amino acid aminotransferase C56E4.03 (EC:2.6.1.57)
Gene namesi
ORF Names:SPAC56E4.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC56E4.03.
PomBaseiSPAC56E4.03.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Aromatic amino acid aminotransferase C56E4.03PRO_0000308489Add
BLAST

Proteomic databases

MaxQBiO14192.

Interactioni

Protein-protein interaction databases

BioGridi279772. 8 interactions.
MINTiMINT-4671254.

Structurei

3D structure databases

ProteinModelPortaliO14192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000223057.
InParanoidiO14192.
KOiK00838.
OMAiGMFHWIE.
OrthoDBiEOG7M6DHB.
PhylomeDBiO14192.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.

Sequencei

Sequence statusi: Complete.

O14192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQPKDLSH HLSVESASRK QSPLKAVALS KSSRNIKIIS LAGGLPNPEY
60 70 80 90 100
FPIREMDAEI PAINSWKKDS SNSGKLDTVS VPMSSSDSDV LPLSVALQYG
110 120 130 140 150
QGSGAALLSQ FLKEHTRIIH NPPYEGWNII MTTGNTSCLD IALRMLTNRG
160 170 180 190 200
DSILVEKYSF PSALQSMRPL GLSCIPIDMD QFGFLPESMD DILTNWDATS
210 220 230 240 250
YGSPKPHVLY TIPTGQNPTG STLSVERRKQ IYTLAQKHDI IILEDEPYYY
260 270 280 290 300
LQMDAYEGKP EAADKAFTNE QFVKELIPSF LSMDVDGRVI RMDSLSKVVA
310 320 330 340 350
PGSRVGWFTA QPLFIERGLR AAETATQSAS GISQGILYAM FKHWGQDGYL
360 370 380 390 400
EWLKHIRYSY TLRRNYLLYA MDTYLPKSVC SYIPPVAGMF IWFEVDKSRY
410 420 430 440 450
IHADKNESIP EIESKIHAEA VEEGVNLACG NWFVVDPRVN DKIFFRVTFA
460 470
HAELEEFNVA IERFAGVLKN NFKC
Length:474
Mass (Da):53,167
Last modified:January 1, 1998 - v1
Checksum:iE546EABC7E884623
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16394.1.
PIRiT38905.
RefSeqiNP_593270.1. NM_001018667.2.

Genome annotation databases

EnsemblFungiiSPAC56E4.03.1; SPAC56E4.03.1:pep; SPAC56E4.03.
GeneIDi2543350.
KEGGispo:SPAC56E4.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16394.1.
PIRiT38905.
RefSeqiNP_593270.1. NM_001018667.2.

3D structure databases

ProteinModelPortaliO14192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279772. 8 interactions.
MINTiMINT-4671254.

Proteomic databases

MaxQBiO14192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC56E4.03.1; SPAC56E4.03.1:pep; SPAC56E4.03.
GeneIDi2543350.
KEGGispo:SPAC56E4.03.

Organism-specific databases

EuPathDBiFungiDB:SPAC56E4.03.
PomBaseiSPAC56E4.03.

Phylogenomic databases

HOGENOMiHOG000223057.
InParanoidiO14192.
KOiK00838.
OMAiGMFHWIE.
OrthoDBiEOG7M6DHB.
PhylomeDBiO14192.

Enzyme and pathway databases

ReactomeiR-SPO-71064. Lysine catabolism.
R-SPO-71240. Tryptophan catabolism.

Miscellaneous databases

NextBioi20804365.
PROiO14192.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAATR1_SCHPO
AccessioniPrimary (citable) accession number: O14192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 1, 1998
Last modified: April 13, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.