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O14189 (PP2C5_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 2C homolog C10F6.17c
EC=3.1.3.16
Alternative name(s):
Pyruvate dehydrogenase (Lipoamide) phosphatase C10F6.17c
Gene names
ORF Names:SPAC10F6.17c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in regulation of pyruvate dehydrogenase activity By similarity.

Catalytic activity

A phosphoprotein + H2O = a protein + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subcellular location

Mitochondrion Ref.2.

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Protein phosphatase 2C homolog C10F6.17c
PRO_0000352809

Regions

Domain84 – 380297PP2C-like

Sites

Metal binding1211Manganese 1 By similarity
Metal binding1211Manganese 2 By similarity
Metal binding1221Manganese 1; via carbonyl oxygen By similarity
Metal binding3441Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
O14189 [UniParc].

Last modified August 21, 2007. Version 4.
Checksum: CF52B91186DB64E8

FASTA44449,741
        10         20         30         40         50         60 
MNFFTSAVGS KVFKRNNFKY VAIAASSIGL AAYHIRKDAI ALDIPNSTYQ HVSKNRVPPT 

        70         80         90        100        110        120 
DGDGITKRLK EFERTVTVNK DGIFRYDFNQ VASNDPCEDD HVEVIDRNID EGNWYFWGIF 

       130        140        150        160        170        180 
DGHSGWNTSL FLRQHLVPAV VRELQKCTAS YYHQNACPSS LALDKSISEA FAKVDHQIVH 

       190        200        210        220        230        240 
EHVSHVFNNP ESLQVAASLL LPALSGSCAL LTSYSAKSKS LQVACTGDSR AVLGECTPDG 

       250        260        270        280        290        300 
SWEAIPLSRD QTGMNPDEAS RLEVEHPGEE VLRNNRILGR LMPSRAFGDA RYKWSQEISE 

       310        320        330        340        350        360 
RLHREYFSAS PIPVKTPPYV TAVPEIESIT VNPKKHRFLI MASDGLWDTM SSEQAVQLVG 

       370        380        390        400        410        420 
EWADTVLGKT TNEKNTTQDD KQSWSLFKKT SKVIDDNAAT HLIRHSLGGS DQRISALLTL 

       430        440 
TYPISRRYRD DITVTVIFFD EKTL

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329670 Genomic DNA. Translation: CAA15730.2.
RefSeqNP_593268.2. NM_001018665.2.

3D structure databases

ProteinModelPortalO14189.
ModBaseSearch...

Protein-protein interaction databases

STRING4896.SPAC10F6.17c-1.

Proteomic databases

PaxDbO14189.
PRIDEO14189.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC10F6.17c.1; SPAC10F6.17c.1:pep; SPAC10F6.17c.
GeneID2543002.
KEGGspo:SPAC10F6.17c.

Organism-specific databases

PomBaseSPAC10F6.17c.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000209682.
KOK01090.
OMATAIPPNY.
OrthoDBEOG4MWCFT.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. PP2C-related. 1 hit.
ProtoNetSearch...

Other

NextBio20804035.

Entry information

Entry namePP2C5_SCHPO
AccessionPrimary (citable) accession number: O14189
Secondary accession number(s): O42655
Entry history
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: August 21, 2007
Last modified: April 3, 2013
This is version 77 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents