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O14189

- PP2C5_SCHPO

UniProt

O14189 - PP2C5_SCHPO

Protein

Protein phosphatase 2C homolog C10F6.17c

Gene

SPAC10F6.17c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 4 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Involved in regulation of pyruvate dehydrogenase activity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi121 – 1211Manganese 1By similarity
    Metal bindingi121 – 1211Manganese 2By similarity
    Metal bindingi122 – 1221Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi344 – 3441Manganese 2By similarity

    GO - Molecular functioni

    1. [pyruvate dehydrogenase (lipoamide)] phosphatase activity Source: PomBase
    2. metal ion binding Source: UniProtKB-KW
    3. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. dephosphorylation Source: PomBase
    2. generation of precursor metabolites and energy Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 2C homolog C10F6.17c (EC:3.1.3.16)
    Alternative name(s):
    Pyruvate dehydrogenase (Lipoamide) phosphatase C10F6.17c
    Gene namesi
    ORF Names:SPAC10F6.17c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC10F6.17c.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Protein phosphatase 2C homolog C10F6.17cPRO_0000352809Add
    BLAST

    Proteomic databases

    MaxQBiO14189.
    PaxDbiO14189.

    Interactioni

    Protein-protein interaction databases

    STRINGi4896.SPAC10F6.17c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO14189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini84 – 380297PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000209682.
    KOiK01102.
    OMAiRFLIMAS.
    OrthoDBiEOG7XWPXK.
    PhylomeDBiO14189.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    O14189-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNFFTSAVGS KVFKRNNFKY VAIAASSIGL AAYHIRKDAI ALDIPNSTYQ    50
    HVSKNRVPPT DGDGITKRLK EFERTVTVNK DGIFRYDFNQ VASNDPCEDD 100
    HVEVIDRNID EGNWYFWGIF DGHSGWNTSL FLRQHLVPAV VRELQKCTAS 150
    YYHQNACPSS LALDKSISEA FAKVDHQIVH EHVSHVFNNP ESLQVAASLL 200
    LPALSGSCAL LTSYSAKSKS LQVACTGDSR AVLGECTPDG SWEAIPLSRD 250
    QTGMNPDEAS RLEVEHPGEE VLRNNRILGR LMPSRAFGDA RYKWSQEISE 300
    RLHREYFSAS PIPVKTPPYV TAVPEIESIT VNPKKHRFLI MASDGLWDTM 350
    SSEQAVQLVG EWADTVLGKT TNEKNTTQDD KQSWSLFKKT SKVIDDNAAT 400
    HLIRHSLGGS DQRISALLTL TYPISRRYRD DITVTVIFFD EKTL 444
    Length:444
    Mass (Da):49,741
    Last modified:August 21, 2007 - v4
    Checksum:iCF52B91186DB64E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA15730.2.
    RefSeqiNP_593268.2. NM_001018665.2.

    Genome annotation databases

    EnsemblFungiiSPAC10F6.17c.1; SPAC10F6.17c.1:pep; SPAC10F6.17c.
    GeneIDi2543002.
    KEGGispo:SPAC10F6.17c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA15730.2 .
    RefSeqi NP_593268.2. NM_001018665.2.

    3D structure databases

    ProteinModelPortali O14189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4896.SPAC10F6.17c-1.

    Proteomic databases

    MaxQBi O14189.
    PaxDbi O14189.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC10F6.17c.1 ; SPAC10F6.17c.1:pep ; SPAC10F6.17c .
    GeneIDi 2543002.
    KEGGi spo:SPAC10F6.17c.

    Organism-specific databases

    PomBasei SPAC10F6.17c.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000209682.
    KOi K01102.
    OMAi RFLIMAS.
    OrthoDBi EOG7XWPXK.
    PhylomeDBi O14189.

    Miscellaneous databases

    NextBioi 20804035.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPP2C5_SCHPO
    AccessioniPrimary (citable) accession number: O14189
    Secondary accession number(s): O42655
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 4, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 85 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3