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O14189

- PP2C5_SCHPO

UniProt

O14189 - PP2C5_SCHPO

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Protein

Protein phosphatase 2C homolog C10F6.17c

Gene

SPAC10F6.17c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in regulation of pyruvate dehydrogenase activity.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi121 – 1211Manganese 1By similarity
Metal bindingi121 – 1211Manganese 2By similarity
Metal bindingi122 – 1221Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi344 – 3441Manganese 2By similarity

GO - Molecular functioni

  1. [pyruvate dehydrogenase (lipoamide)] phosphatase activity Source: PomBase
  2. metal ion binding Source: UniProtKB-KW
  3. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. dephosphorylation Source: PomBase
  2. generation of precursor metabolites and energy Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog C10F6.17c (EC:3.1.3.16)
Alternative name(s):
Pyruvate dehydrogenase (Lipoamide) phosphatase C10F6.17c
Gene namesi
ORF Names:SPAC10F6.17c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC10F6.17c.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Protein phosphatase 2C homolog C10F6.17cPRO_0000352809Add
BLAST

Proteomic databases

MaxQBiO14189.
PaxDbiO14189.

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC10F6.17c-1.

Structurei

3D structure databases

ProteinModelPortaliO14189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 380297PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000209682.
InParanoidiO14189.
KOiK01102.
OMAiRFLIMAS.
OrthoDBiEOG7XWPXK.
PhylomeDBiO14189.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.

Sequencei

Sequence statusi: Complete.

O14189-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFFTSAVGS KVFKRNNFKY VAIAASSIGL AAYHIRKDAI ALDIPNSTYQ
60 70 80 90 100
HVSKNRVPPT DGDGITKRLK EFERTVTVNK DGIFRYDFNQ VASNDPCEDD
110 120 130 140 150
HVEVIDRNID EGNWYFWGIF DGHSGWNTSL FLRQHLVPAV VRELQKCTAS
160 170 180 190 200
YYHQNACPSS LALDKSISEA FAKVDHQIVH EHVSHVFNNP ESLQVAASLL
210 220 230 240 250
LPALSGSCAL LTSYSAKSKS LQVACTGDSR AVLGECTPDG SWEAIPLSRD
260 270 280 290 300
QTGMNPDEAS RLEVEHPGEE VLRNNRILGR LMPSRAFGDA RYKWSQEISE
310 320 330 340 350
RLHREYFSAS PIPVKTPPYV TAVPEIESIT VNPKKHRFLI MASDGLWDTM
360 370 380 390 400
SSEQAVQLVG EWADTVLGKT TNEKNTTQDD KQSWSLFKKT SKVIDDNAAT
410 420 430 440
HLIRHSLGGS DQRISALLTL TYPISRRYRD DITVTVIFFD EKTL
Length:444
Mass (Da):49,741
Last modified:August 21, 2007 - v4
Checksum:iCF52B91186DB64E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA15730.2.
RefSeqiNP_593268.2. NM_001018665.2.

Genome annotation databases

EnsemblFungiiSPAC10F6.17c.1; SPAC10F6.17c.1:pep; SPAC10F6.17c.
GeneIDi2543002.
KEGGispo:SPAC10F6.17c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA15730.2 .
RefSeqi NP_593268.2. NM_001018665.2.

3D structure databases

ProteinModelPortali O14189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4896.SPAC10F6.17c-1.

Proteomic databases

MaxQBi O14189.
PaxDbi O14189.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC10F6.17c.1 ; SPAC10F6.17c.1:pep ; SPAC10F6.17c .
GeneIDi 2543002.
KEGGi spo:SPAC10F6.17c.

Organism-specific databases

PomBasei SPAC10F6.17c.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000209682.
InParanoidi O14189.
KOi K01102.
OMAi RFLIMAS.
OrthoDBi EOG7XWPXK.
PhylomeDBi O14189.

Miscellaneous databases

NextBioi 20804035.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPP2C5_SCHPO
AccessioniPrimary (citable) accession number: O14189
Secondary accession number(s): O42655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 86 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3