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Protein

Pre-mRNA-processing protein prp40

Gene

prp40

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • mRNA cis splicing, via spliceosome Source: PomBase
  • mRNA splicing, via spliceosome Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-processing protein prp40
Gene namesi
Name:prp40
ORF Names:SPAC4D7.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4D7.13.
PomBaseiSPAC4D7.13.

Subcellular locationi

GO - Cellular componenti

  • commitment complex Source: PomBase
  • nucleus Source: PomBase
  • U1 snRNP Source: PomBase
  • U2-type prespliceosome Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345631 – 695Pre-mRNA-processing protein prp40Add BLAST695

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei688Phosphoserine1 Publication1
Modified residuei689Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14176.
PRIDEiO14176.

PTM databases

iPTMnetiO14176.

Interactioni

Protein-protein interaction databases

BioGridi279831. 26 interactors.
MINTiMINT-4671131.

Structurei

3D structure databases

ProteinModelPortaliO14176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 63WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini71 – 104WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini191 – 245FF 1Add BLAST55
Domaini257 – 313FF 2Add BLAST57
Domaini326 – 385FF 3Add BLAST60
Domaini403 – 465FF 4Add BLAST63
Domaini470 – 521FF 5Add BLAST52
Domaini544 – 601FF 6Add BLAST58

Sequence similaritiesi

Contains 6 FF domains.Curated
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiO14176.
KOiK12821.
OMAiRDPRYWM.
OrthoDBiEOG092C1L62.
PhylomeDBiO14176.

Family and domain databases

Gene3Di1.10.10.440. 5 hits.
InterProiIPR002713. FF_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF01846. FF. 4 hits.
PF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00441. FF. 5 hits.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF81698. SSF81698. 5 hits.
PROSITEiPS51676. FF. 6 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPPWQTSE YDETEGFTSN QEGPSAAPSK TVASDWHEVK TEDSRVYYYN
60 70 80 90 100
SVTRKSVWEK PEELMNDFEK KLSKLAWKEY ATADGKKYWY NVNTRESVWD
110 120 130 140 150
IPDEYKAALV DEPEQQKKAL SSKIKSNDNK PAVQSIQRHG PDVAAPSSQP
160 170 180 190 200
AKDQSQQISQ GSHKRTINFV QQKDKRQKRS NDYQHENYDT YEAAERAFFK
210 220 230 240 250
FLDSHNVNPS WTWEQTVREL CDAKGYYVMK DPWHRKCAFD AYILNYLTDQ
260 270 280 290 300
SDAEKNRVTK IRKEFIEMLK SSDKIHSYTL WRTVKNEFSS HPAFNATSSE
310 320 330 340 350
TEQQQLFFEY KQKLLEDEKQ LEKDRRKEAL DDFCSLLRNM NFEPYTRWSV
360 370 380 390 400
AQAKFDQDPR YTRNSNMKYL SKLDALVAFE DHVKHLEREY ILDKQKQKKE
410 420 430 440 450
KHRIERKNRD AFRALLQDLR VQKKITLRTK WKELYPIIKD DPRYLNLLGQ
460 470 480 490 500
SGSTPLDLFW DTIVDLENMY REKRNLVLDC LEVLQISVDD TSNIPEIIAR
510 520 530 540 550
LSEKLKDREE SEAVTEDLIE EVVNRLRDKA IHKKAEEKRA DERRIRRKID
560 570 580 590 600
NLRSAIKYLK PPISADASYD EIRPLISILP EFAALHSEEH RMAAFDKYIR
610 620 630 640 650
RLREKRELEK QYQNRRGYYD VGKDESYLAN SARPHSGYED GRLEYSADLA
660 670 680 690
SKSNRNEINT MQDVQENSIS HVTATQPAVK NIVDDAESSE EGEIR
Length:695
Mass (Da):81,931
Last modified:January 1, 1998 - v1
Checksum:iCB5D333C4DB486B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11285.1.
PIRiT38804.
RefSeqiNP_594966.1. NM_001020397.2.

Genome annotation databases

EnsemblFungiiSPAC4D7.13.1; SPAC4D7.13.1:pep; SPAC4D7.13.
GeneIDi2543409.
KEGGispo:SPAC4D7.13.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11285.1.
PIRiT38804.
RefSeqiNP_594966.1. NM_001020397.2.

3D structure databases

ProteinModelPortaliO14176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279831. 26 interactors.
MINTiMINT-4671131.

PTM databases

iPTMnetiO14176.

Proteomic databases

MaxQBiO14176.
PRIDEiO14176.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4D7.13.1; SPAC4D7.13.1:pep; SPAC4D7.13.
GeneIDi2543409.
KEGGispo:SPAC4D7.13.

Organism-specific databases

EuPathDBiFungiDB:SPAC4D7.13.
PomBaseiSPAC4D7.13.

Phylogenomic databases

InParanoidiO14176.
KOiK12821.
OMAiRDPRYWM.
OrthoDBiEOG092C1L62.
PhylomeDBiO14176.

Miscellaneous databases

PROiO14176.

Family and domain databases

Gene3Di1.10.10.440. 5 hits.
InterProiIPR002713. FF_domain.
IPR001202. WW_dom.
[Graphical view]
PfamiPF01846. FF. 4 hits.
PF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00441. FF. 5 hits.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF81698. SSF81698. 5 hits.
PROSITEiPS51676. FF. 6 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRP40_SCHPO
AccessioniPrimary (citable) accession number: O14176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.