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Protein

WD repeat-containing protein pop2

Gene

pop2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop1, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells.4 Publications

GO - Molecular functioni

  • protein binding, bridging Source: PomBase

GO - Biological processi

  • negative regulation of mitotic DNA replication initiation Source: PomBase
  • protein modification by small protein conjugation or removal Source: PomBase
  • ubiquitin-dependent protein catabolic process Source: PomBase

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-8951664 Neddylation
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein pop2
Alternative name(s):
Proteolysis factor sud1
Gene namesi
Name:pop2
Synonyms:sud1
ORF Names:SPAC4D7.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4D7.03
PomBaseiSPAC4D7.03 pop2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511401 – 703WD repeat-containing protein pop2Add BLAST703

Proteomic databases

MaxQBiO14170
PaxDbiO14170
PRIDEiO14170

Interactioni

Subunit structurei

Homodimer and heterodimer with pop1. Binds to cul1, pip1 and phosphorylated cdc18.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein binding, bridging Source: PomBase

Protein-protein interaction databases

BioGridi279932, 72 interactors
IntActiO14170, 6 interactors
MINTiO14170
STRINGi4896.SPAC4D7.03.1

Structurei

3D structure databases

ProteinModelPortaliO14170
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini236 – 283F-boxPROSITE-ProRule annotationAdd BLAST48
Repeati389 – 417WD 1Add BLAST29
Repeati429 – 473WD 2Add BLAST45
Repeati505 – 533WD 3Add BLAST29
Repeati545 – 575WD 4Add BLAST31
Repeati587 – 615WD 5Add BLAST29
Repeati625 – 654WD 6Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 170Interaction with pop1Add BLAST170

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiO14170
KOiK03361
OMAiCLQHDDE
OrthoDBiEOG092C10HM
PhylomeDBiO14170

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00646 F-box, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O14170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSRCPTDN SSSRINSSVP LINSSSPATP PESFDPQVFP SSLIHGDNLL
60 70 80 90 100
PQDDQIASDP RSESNSCNGN TSSSLPCTDS YQYPLKHSCT PSFLRKFNES
110 120 130 140 150
IENVSYKCLD HSPPDSVPGD FSISLVPQRN FLYSHSSLPP KIISIDRNNR
160 170 180 190 200
IKLDNSISSN SDNFPPSPKV DTSNTVSPGS KPISEDLEDL NLQSIVQTFE
210 220 230 240 250
DLPEGIQSYA FFQLLRSCNR QSMRLLLNEC EPLLKKDILS NLPFSIVQSI
260 270 280 290 300
LLNLDIHSFL SCRLVSPTWN RILDVHTSYW KHMFSLFGFQ INENDWKYAN
310 320 330 340 350
PNLNRPPFLH NDQISDDYFP EIFKRHFLNR KRWLFPSIPP SHLSFPIHVP
360 370 380 390 400
NFMITSLLLH KDRIITTSGS GTIQIHNAIT GVLEARLEGH KEGVWAVKIH
410 420 430 440 450
ENTLVSGSID KTVRVWNIEK AKCTHIFRGH ISIIRCLEIL VPSRLIRHGV
460 470 480 490 500
EIVEPDQPYI VSGSRDHTLR VWKLPKNTDP PYLPDNTNSI DRWEKNPYFV
510 520 530 540 550
HTLIGHTDSV RTISGYGDIL VSGSYDSSIR IWRVSTGECL YHLRGHSLRI
560 570 580 590 600
YSVLYEPERN ICISGSMDKS IRVWDLSTGT CKYVLEGHDA FVTLLNVFQN
610 620 630 640 650
RLISGSADST IRIWDLNTGK PLMVLPSNSG YISSFVSDEH KIISGNDGSV
660 670 680 690 700
KLWDVRTGKL LRFLLTDLTK IWHVDFDAMR CVAAVQRDDQ AYLEVINFSG

SRP
Length:703
Mass (Da):79,605
Last modified:January 1, 1998 - v1
Checksum:i0336A0568C152396
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038867 mRNA Translation: AAB95480.1
AF064515 Genomic DNA Translation: AAC39496.1
CU329670 Genomic DNA Translation: CAB11275.1
PIRiT43557
RefSeqiNP_594956.1, NM_001020387.2

Genome annotation databases

EnsemblFungiiSPAC4D7.03.1; SPAC4D7.03.1:pep; SPAC4D7.03
GeneIDi2543514
KEGGispo:SPAC4D7.03

Similar proteinsi

Entry informationi

Entry nameiPOP2_SCHPO
AccessioniPrimary (citable) accession number: O14170
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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