Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eukaryotic translation initiation factor 3 subunit C

Gene

nip1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SPO-72649. Translation initiation complex formation.
R-SPO-72689. Formation of a pool of free 40S subunits.
R-SPO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SPO-72702. Ribosomal scanning and start codon recognition.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit CUniRule annotation
Short name:
eIF3cUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 93 kDa subunit homologUniRule annotation
Short name:
eIF3 p93UniRule annotation
Translation initiation factor eIF3, p93 subunit homologUniRule annotation
Gene namesi
Name:nip1
Synonyms:eif3c, tif33
ORF Names:SPAC1E11.01c, SPAC4A8.16c, SPAC823.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4A8.16c.
PomBaseiSPAC4A8.16c.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

  • cytosol Source: PomBase
  • eukaryotic 43S preinitiation complex Source: PomBase
  • eukaryotic 48S preinitiation complex Source: UniProtKB-HAMAP
  • eukaryotic translation initiation factor 3 complex, eIF3e Source: PomBase
  • eukaryotic translation initiation factor 3 complex, eIF3m Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001235291 – 918Eukaryotic translation initiation factor 3 subunit CAdd BLAST918

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineUniRule annotation1 Publication1
Modified residuei12PhosphoserineUniRule annotation1 Publication1
Modified residuei16PhosphoserineUniRule annotation1 Publication1
Modified residuei19PhosphoserineUniRule annotation1 Publication1
Modified residuei20PhosphoserineUniRule annotation1 Publication1
Modified residuei667PhosphothreonineUniRule annotation1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14164.
PRIDEiO14164.

PTM databases

iPTMnetiO14164.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex appears to include tif32/eif3a, SPAC25G10.08/eif3b, tif33/eif3c, SPBC4C3.07/eif3f, tif35/eif3g and sum1/eif3i. This set of common subunits may also associate exclusively with either moe1/eif3d and int6/eif3e, or with SPAC821.05/eif3h and SPAC1751.03/eif3m. The eIF-3 complex may also include SPAC3A12.13c/eif3j.UniRule annotation2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi280035. 6 interactors.
MINTiMINT-4671055.

Structurei

3D structure databases

ProteinModelPortaliO14164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini723 – 853PCIUniRule annotationAdd BLAST131

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 188Asp/Glu/Ser-richAdd BLAST188

Sequence similaritiesi

Belongs to the eIF-3 subunit C family.UniRule annotation
Contains 1 PCI domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000029414.
InParanoidiO14164.
KOiK03252.
OMAiIIMSESV.
OrthoDBiEOG092C17F5.
PhylomeDBiO14164.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03002. eIF3c. 1 hit.
InterProiIPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

O14164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFFKGGSS DSDAESVDSS EENRLTSSRL KKQDDSSSEE ESSEEESASS
60 70 80 90 100
SESESSEEES ESEESEVEVP KKKAVAASED SESDSESSEE EEETESEEDS
110 120 130 140 150
EVSDESESES ESESESEEES ESEEESDESE RSGPSSFLKK PEKEEAKPAG
160 170 180 190 200
LKFLRGESSE ESSDEEEGRR VVKSAKDKRY EEFISCMETI KNAMSSNNWI
210 220 230 240 250
VVSNEFDHLN KVSQKCKEAG RNPPPYIEFL SALDQKLESA DKAFIKSLDA
260 270 280 290 300
ANGRAFNALK QRVRKNNRQF QSDIDRYRKD PEGFMKPAEL NEIPKPAGKA
310 320 330 340 350
GQDEVIVDGV ATRGIVAPTE GLGKPEEITP ADIFKYLRAI FEARGKKSTD
360 370 380 390 400
RSEQIRLLEK LSTIAVTDYQ RLRVKVALLA VRFDINTGSG QYMPIDQWNA
410 420 430 440 450
ALTELHSILD IFDANPKIVI VEQVEDENEE EEEAIAAAEN NNGVIQVQGS
460 470 480 490 500
VVSFLERLDD EFTRSLQMID PHTPEYIDRL KDETSLYTLL VRSQGYLERI
510 520 530 540 550
GVVENTARLI MRRLDRVYYK PEQVIRANEE VAWRSFPPTF DLTITPRATT
560 570 580 590 600
TTPDILIHSL CVYLYNNGVS LLRTRAMLCH IYHEALQNRF YKARDMLLMS
610 620 630 640 650
HLQDSVHAAD IATQILHNRT MVQIGLCAFR NGMVQETQYA LQDISTTGRV
660 670 680 690 700
KELLGQGIQA PKFGQFTPDQ DRLDKQLVLP FHMHINLELL ECVYLTCSML
710 720 730 740 750
MEIPAMAAAS STASDSRKRV ISRPFRRMLE YIDRQLFVGP PENTREYIMQ
760 770 780 790 800
ASKALADGEW RRCEEFIHAI KIWSLMPDAD KIKQMLSEKI REEGLRTYLL
810 820 830 840 850
AYAAFYDSVS LEFLATTFDL PVQRVTVIVS RLLSKREIHA ALDQVHGAII
860 870 880 890 900
FERVEINKLE SLTVSLSEKT AQLNEANEKL YEQKTQHTNP QENRRRDKGG
910
SVKRRNERTE NRNRSDMN
Length:918
Mass (Da):104,367
Last modified:April 27, 2001 - v2
Checksum:i43B70599409688EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti683M → I in BAA13802 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11485.1.
Z98599 Genomic DNA. Translation: CAB11250.2.
D89140 mRNA. Translation: BAA13802.1.
PIRiT38786.
T42417.
RefSeqiNP_593828.2. NM_001019257.2.

Genome annotation databases

EnsemblFungiiSPAC4A8.16c.1; SPAC4A8.16c.1:pep; SPAC4A8.16c.
GeneIDi2543621.
KEGGispo:SPAC4A8.16c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB11485.1.
Z98599 Genomic DNA. Translation: CAB11250.2.
D89140 mRNA. Translation: BAA13802.1.
PIRiT38786.
T42417.
RefSeqiNP_593828.2. NM_001019257.2.

3D structure databases

ProteinModelPortaliO14164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi280035. 6 interactors.
MINTiMINT-4671055.

PTM databases

iPTMnetiO14164.

Proteomic databases

MaxQBiO14164.
PRIDEiO14164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4A8.16c.1; SPAC4A8.16c.1:pep; SPAC4A8.16c.
GeneIDi2543621.
KEGGispo:SPAC4A8.16c.

Organism-specific databases

EuPathDBiFungiDB:SPAC4A8.16c.
PomBaseiSPAC4A8.16c.

Phylogenomic databases

HOGENOMiHOG000029414.
InParanoidiO14164.
KOiK03252.
OMAiIIMSESV.
OrthoDBiEOG092C17F5.
PhylomeDBiO14164.

Enzyme and pathway databases

ReactomeiR-SPO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SPO-72649. Translation initiation complex formation.
R-SPO-72689. Formation of a pool of free 40S subunits.
R-SPO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SPO-72702. Ribosomal scanning and start codon recognition.

Miscellaneous databases

PROiO14164.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_03002. eIF3c. 1 hit.
InterProiIPR027516. EIF3C.
IPR008905. EIF3C_N_dom.
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05470. eIF-3c_N. 1 hit.
PF01399. PCI. 1 hit.
[Graphical view]
SMARTiSM00088. PINT. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEIF3C_SCHPO
AccessioniPrimary (citable) accession number: O14164
Secondary accession number(s): O13885, P78791, Q9P6P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.