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Protein

Eukaryotic translation initiation factor 3 subunit C

Gene

nip1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

  • translation initiation factor activity Source: PomBase
  • translation initiation factor binding Source: GO_Central

GO - Biological processi

  • formation of cytoplasmic translation initiation complex Source: PomBase
  • translational initiation Source: GO_Central

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SPO-72689 Formation of a pool of free 40S subunits
R-SPO-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-SPO-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit CUniRule annotation
Short name:
eIF3cUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 93 kDa subunit homologUniRule annotation
Short name:
eIF3 p93UniRule annotation
Translation initiation factor eIF3, p93 subunit homologUniRule annotation
Gene namesi
Name:nip1
Synonyms:eif3c, tif33
ORF Names:SPAC1E11.01c, SPAC4A8.16c, SPAC823.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4A8.16c
PomBaseiSPAC4A8.16c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001235291 – 918Eukaryotic translation initiation factor 3 subunit CAdd BLAST918

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineUniRule annotation1 Publication1
Modified residuei12PhosphoserineUniRule annotation1 Publication1
Modified residuei16PhosphoserineUniRule annotation1 Publication1
Modified residuei19PhosphoserineUniRule annotation1 Publication1
Modified residuei20PhosphoserineUniRule annotation1 Publication1
Modified residuei667PhosphothreonineUniRule annotation1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14164
PaxDbiO14164
PRIDEiO14164

PTM databases

iPTMnetiO14164

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex appears to include tif32/eif3a, SPAC25G10.08/eif3b, tif33/eif3c, SPBC4C3.07/eif3f, tif35/eif3g and sum1/eif3i. This set of common subunits may also associate exclusively with either moe1/eif3d and int6/eif3e, or with SPAC821.05/eif3h and SPAC1751.03/eif3m. The eIF-3 complex may also include SPAC3A12.13c/eif3j.UniRule annotation2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi280035, 5 interactors
STRINGi4896.SPAC4A8.16c.1

Structurei

3D structure databases

ProteinModelPortaliO14164
SMRiO14164
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini681 – 856PCIPROSITE-ProRule annotationAdd BLAST176

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 188Asp/Glu/Ser-richAdd BLAST188

Sequence similaritiesi

Belongs to the eIF-3 subunit C family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000029414
InParanoidiO14164
KOiK03252
OMAiVVMHRSE
OrthoDBiEOG092C17F5
PhylomeDBiO14164

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_03002 eIF3c, 1 hit
InterProiView protein in InterPro
IPR027516 EIF3C
IPR008905 EIF3C_N_dom
IPR000717 PCI_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05470 eIF-3c_N, 1 hit
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequencei

Sequence statusi: Complete.

O14164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFFKGGSS DSDAESVDSS EENRLTSSRL KKQDDSSSEE ESSEEESASS
60 70 80 90 100
SESESSEEES ESEESEVEVP KKKAVAASED SESDSESSEE EEETESEEDS
110 120 130 140 150
EVSDESESES ESESESEEES ESEEESDESE RSGPSSFLKK PEKEEAKPAG
160 170 180 190 200
LKFLRGESSE ESSDEEEGRR VVKSAKDKRY EEFISCMETI KNAMSSNNWI
210 220 230 240 250
VVSNEFDHLN KVSQKCKEAG RNPPPYIEFL SALDQKLESA DKAFIKSLDA
260 270 280 290 300
ANGRAFNALK QRVRKNNRQF QSDIDRYRKD PEGFMKPAEL NEIPKPAGKA
310 320 330 340 350
GQDEVIVDGV ATRGIVAPTE GLGKPEEITP ADIFKYLRAI FEARGKKSTD
360 370 380 390 400
RSEQIRLLEK LSTIAVTDYQ RLRVKVALLA VRFDINTGSG QYMPIDQWNA
410 420 430 440 450
ALTELHSILD IFDANPKIVI VEQVEDENEE EEEAIAAAEN NNGVIQVQGS
460 470 480 490 500
VVSFLERLDD EFTRSLQMID PHTPEYIDRL KDETSLYTLL VRSQGYLERI
510 520 530 540 550
GVVENTARLI MRRLDRVYYK PEQVIRANEE VAWRSFPPTF DLTITPRATT
560 570 580 590 600
TTPDILIHSL CVYLYNNGVS LLRTRAMLCH IYHEALQNRF YKARDMLLMS
610 620 630 640 650
HLQDSVHAAD IATQILHNRT MVQIGLCAFR NGMVQETQYA LQDISTTGRV
660 670 680 690 700
KELLGQGIQA PKFGQFTPDQ DRLDKQLVLP FHMHINLELL ECVYLTCSML
710 720 730 740 750
MEIPAMAAAS STASDSRKRV ISRPFRRMLE YIDRQLFVGP PENTREYIMQ
760 770 780 790 800
ASKALADGEW RRCEEFIHAI KIWSLMPDAD KIKQMLSEKI REEGLRTYLL
810 820 830 840 850
AYAAFYDSVS LEFLATTFDL PVQRVTVIVS RLLSKREIHA ALDQVHGAII
860 870 880 890 900
FERVEINKLE SLTVSLSEKT AQLNEANEKL YEQKTQHTNP QENRRRDKGG
910
SVKRRNERTE NRNRSDMN
Length:918
Mass (Da):104,367
Last modified:April 27, 2001 - v2
Checksum:i43B70599409688EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti683M → I in BAA13802 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB11485.1
Z98599 Genomic DNA Translation: CAB11250.2
D89140 mRNA Translation: BAA13802.1
PIRiT38786
T42417
RefSeqiNP_593828.2, NM_001019257.2

Genome annotation databases

EnsemblFungiiSPAC4A8.16c.1; SPAC4A8.16c.1:pep; SPAC4A8.16c
GeneIDi2543621
KEGGispo:SPAC4A8.16c

Similar proteinsi

Entry informationi

Entry nameiEIF3C_SCHPO
AccessioniPrimary (citable) accession number: O14164
Secondary accession number(s): O13885, P78791, Q9P6P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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