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Protein

Valine--tRNA ligase, mitochondrial

Gene

vas1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei559ATPBy similarity1

GO - Molecular functioni

  • aminoacyl-tRNA editing activity Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • valine-tRNA ligase activity Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.1.1.9. 5613.

Names & Taxonomyi

Protein namesi
Recommended name:
Valine--tRNA ligase, mitochondrial (EC:6.1.1.9)
Alternative name(s):
Valyl-tRNA synthetase
Short name:
ValRS
Gene namesi
Name:vas1
ORF Names:SPAC4A8.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4A8.08c.
PomBaseiSPAC4A8.08c.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 90MitochondrionAdd BLAST90
ChainiPRO_000035284991 – 950Valine--tRNA ligase, mitochondrialAdd BLAST860

Proteomic databases

MaxQBiO14160.
PRIDEiO14160.

Interactioni

Protein-protein interaction databases

BioGridi280018. 2 interactors.
MINTiMINT-4671023.

Structurei

3D structure databases

ProteinModelPortaliO14160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi67 – 77"HIGH" regionAdd BLAST11
Motifi556 – 560"KMSKS" region5

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000020094.
InParanoidiO14160.
KOiK01873.
OMAiNTIMREP.
OrthoDBiEOG092C0H3K.
PhylomeDBiO14160.

Family and domain databases

CDDicd07962. Anticodon_Ia_Val. 1 hit.
Gene3Di1.10.730.10. 2 hits.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR033705. Anticodon_Ia_Val.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PANTHERiPTHR11946:SF5. PTHR11946:SF5. 3 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14160-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHFQRSFSS RKAHGLLSFK NRNYIHIEAP FDIAAIQDGW NIIRKHIHYP
60 70 80 90 100
KPKSIEAPMF PILLPPPNIT GKLHIGHALT ITIQDALARF YAMHGYKVSF
110 120 130 140 150
RPGTDHAGIA TQSVVEKYLQ KKGVYRNQLS KDELLSSIHS WQVKYQKSII
160 170 180 190 200
NQLKSFEAIF DWDNIFYTMD QNRSEAVNEA FISLFNAGLI YRANRFVNWC
210 220 230 240 250
PKLESAVSDI EVESQQINKP VTKYVDNTPV EFGWLYEISY QLEGSDNEQL
260 270 280 290 300
NVSTTRPETI FGDRAIAVSP HDERYKKYVG RFVKHPLIDD LLIPVICDNA
310 320 330 340 350
VDRHFGTGVL KITPMHSIVD YEIAKRHNID CVSIMDKSGN LINCSKEVNG
360 370 380 390 400
MNRLKARSKI VRLLQQRNRL VEQVPHSLIL SVCSRTGDVI EPVMVPQWYL
410 420 430 440 450
SVDSLKKEVL KSSNKLKLVP SLARKEWDSW FKKMGDWCIS RQIWWGHQIP
460 470 480 490 500
VWKILEEDKW IAAPNYEKAL QLSVGKSVSQ DSDVLDTWFS SALLPLSAFG
510 520 530 540 550
WPKSKDIQPL PFIESGQDIL FFWIARMALL CKYFSNELPF KEIILHPLVR
560 570 580 590 600
DSEGRKMSKS LGNVIDPMDI INGVTLENMK KALLEGNLPI SEVHKSSKQM
610 620 630 640 650
EKAFPNGIPA QGIDIFRYGL FLCLHHEQRI LLDMNSFSDA HRFVSKLWNL
660 670 680 690 700
ARYFNQYKDK ENPLKLTDSQ RQRISLLKMA TYSKLHHAVE GVKESFEQRK
710 720 730 740 750
FFNAADIMKN FLLNDLSSVY VELTRFDVKD SKSSAYEVYR VFSDILHIFL
760 770 780 790 800
KLIHPIVPCI SGVMLHSKII PERKNSEFLS FPTSQQECLL VHDNQAEVVV
810 820 830 840 850
QNAYDVLIQL RKLESPLNKS PSREHTVYIS TSLEPLKYFY DAIEQSTNLK
860 870 880 890 900
LKSISQEDTI DLMRNQTFIL SRISSDTILL VPKKLYPSKR KKLRKNLDDL
910 920 930 940 950
QKKLDKIQHT TSSSGYEKAP SYIKLKNCEL QKDILVKIQD IKQALLNTEI
Length:950
Mass (Da):109,627
Last modified:May 1, 1999 - v2
Checksum:i923B080350E3F40B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB38577.1.
PIRiT38777.
RefSeqiNP_593819.1. NM_001019249.2.

Genome annotation databases

EnsemblFungiiSPAC4A8.08c.1; SPAC4A8.08c.1:pep; SPAC4A8.08c.
GeneIDi2543603.
KEGGispo:SPAC4A8.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB38577.1.
PIRiT38777.
RefSeqiNP_593819.1. NM_001019249.2.

3D structure databases

ProteinModelPortaliO14160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi280018. 2 interactors.
MINTiMINT-4671023.

Proteomic databases

MaxQBiO14160.
PRIDEiO14160.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4A8.08c.1; SPAC4A8.08c.1:pep; SPAC4A8.08c.
GeneIDi2543603.
KEGGispo:SPAC4A8.08c.

Organism-specific databases

EuPathDBiFungiDB:SPAC4A8.08c.
PomBaseiSPAC4A8.08c.

Phylogenomic databases

HOGENOMiHOG000020094.
InParanoidiO14160.
KOiK01873.
OMAiNTIMREP.
OrthoDBiEOG092C0H3K.
PhylomeDBiO14160.

Enzyme and pathway databases

BRENDAi6.1.1.9. 5613.

Miscellaneous databases

PROiO14160.

Family and domain databases

CDDicd07962. Anticodon_Ia_Val. 1 hit.
Gene3Di1.10.730.10. 2 hits.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR033705. Anticodon_Ia_Val.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PANTHERiPTHR11946:SF5. PTHR11946:SF5. 3 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYVM_SCHPO
AccessioniPrimary (citable) accession number: O14160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: May 1, 1999
Last modified: October 5, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.