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O14160

- SYVM_SCHPO

UniProt

O14160 - SYVM_SCHPO

Protein

Valine--tRNA ligase, mitochondrial

Gene

vas1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei559 – 5591ATPBy similarity

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. valine-tRNA ligase activity Source: PomBase

    GO - Biological processi

    1. mitochondrial valyl-tRNA aminoacylation Source: PomBase

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Valine--tRNA ligase, mitochondrial (EC:6.1.1.9)
    Alternative name(s):
    Valyl-tRNA synthetase
    Short name:
    ValRS
    Gene namesi
    Name:vas1
    ORF Names:SPAC4A8.08c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC4A8.08c.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 9090MitochondrionAdd
    BLAST
    Chaini91 – 950860Valine--tRNA ligase, mitochondrialPRO_0000352849Add
    BLAST

    Proteomic databases

    MaxQBiO14160.

    Interactioni

    Protein-protein interaction databases

    BioGridi280018. 2 interactions.
    MINTiMINT-4671023.
    STRINGi4896.SPAC4A8.08c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO14160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi67 – 7711"HIGH" regionAdd
    BLAST
    Motifi556 – 5605"KMSKS" region

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0525.
    HOGENOMiHOG000020094.
    KOiK01873.
    OMAiAEANTIM.
    OrthoDBiEOG7H1JTZ.
    PhylomeDBiO14160.

    Family and domain databases

    Gene3Di1.10.730.10. 2 hits.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    IPR002303. Valyl-tRNA_ligase.
    [Graphical view]
    PANTHERiPTHR11946:SF5. PTHR11946:SF5. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    PRINTSiPR00986. TRNASYNTHVAL.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00422. valS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14160-1 [UniParc]FASTAAdd to Basket

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    MFHFQRSFSS RKAHGLLSFK NRNYIHIEAP FDIAAIQDGW NIIRKHIHYP    50
    KPKSIEAPMF PILLPPPNIT GKLHIGHALT ITIQDALARF YAMHGYKVSF 100
    RPGTDHAGIA TQSVVEKYLQ KKGVYRNQLS KDELLSSIHS WQVKYQKSII 150
    NQLKSFEAIF DWDNIFYTMD QNRSEAVNEA FISLFNAGLI YRANRFVNWC 200
    PKLESAVSDI EVESQQINKP VTKYVDNTPV EFGWLYEISY QLEGSDNEQL 250
    NVSTTRPETI FGDRAIAVSP HDERYKKYVG RFVKHPLIDD LLIPVICDNA 300
    VDRHFGTGVL KITPMHSIVD YEIAKRHNID CVSIMDKSGN LINCSKEVNG 350
    MNRLKARSKI VRLLQQRNRL VEQVPHSLIL SVCSRTGDVI EPVMVPQWYL 400
    SVDSLKKEVL KSSNKLKLVP SLARKEWDSW FKKMGDWCIS RQIWWGHQIP 450
    VWKILEEDKW IAAPNYEKAL QLSVGKSVSQ DSDVLDTWFS SALLPLSAFG 500
    WPKSKDIQPL PFIESGQDIL FFWIARMALL CKYFSNELPF KEIILHPLVR 550
    DSEGRKMSKS LGNVIDPMDI INGVTLENMK KALLEGNLPI SEVHKSSKQM 600
    EKAFPNGIPA QGIDIFRYGL FLCLHHEQRI LLDMNSFSDA HRFVSKLWNL 650
    ARYFNQYKDK ENPLKLTDSQ RQRISLLKMA TYSKLHHAVE GVKESFEQRK 700
    FFNAADIMKN FLLNDLSSVY VELTRFDVKD SKSSAYEVYR VFSDILHIFL 750
    KLIHPIVPCI SGVMLHSKII PERKNSEFLS FPTSQQECLL VHDNQAEVVV 800
    QNAYDVLIQL RKLESPLNKS PSREHTVYIS TSLEPLKYFY DAIEQSTNLK 850
    LKSISQEDTI DLMRNQTFIL SRISSDTILL VPKKLYPSKR KKLRKNLDDL 900
    QKKLDKIQHT TSSSGYEKAP SYIKLKNCEL QKDILVKIQD IKQALLNTEI 950
    Length:950
    Mass (Da):109,627
    Last modified:May 1, 1999 - v2
    Checksum:i923B080350E3F40B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB38577.1.
    PIRiT38777.
    RefSeqiNP_593819.1. NM_001019249.2.

    Genome annotation databases

    EnsemblFungiiSPAC4A8.08c.1; SPAC4A8.08c.1:pep; SPAC4A8.08c.
    GeneIDi2543603.
    KEGGispo:SPAC4A8.08c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB38577.1 .
    PIRi T38777.
    RefSeqi NP_593819.1. NM_001019249.2.

    3D structure databases

    ProteinModelPortali O14160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 280018. 2 interactions.
    MINTi MINT-4671023.
    STRINGi 4896.SPAC4A8.08c-1.

    Proteomic databases

    MaxQBi O14160.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC4A8.08c.1 ; SPAC4A8.08c.1:pep ; SPAC4A8.08c .
    GeneIDi 2543603.
    KEGGi spo:SPAC4A8.08c.

    Organism-specific databases

    PomBasei SPAC4A8.08c.

    Phylogenomic databases

    eggNOGi COG0525.
    HOGENOMi HOG000020094.
    KOi K01873.
    OMAi AEANTIM.
    OrthoDBi EOG7H1JTZ.
    PhylomeDBi O14160.

    Miscellaneous databases

    NextBioi 20804610.

    Family and domain databases

    Gene3Di 1.10.730.10. 2 hits.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    IPR002303. Valyl-tRNA_ligase.
    [Graphical view ]
    PANTHERi PTHR11946:SF5. PTHR11946:SF5. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00986. TRNASYNTHVAL.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00422. valS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSYVM_SCHPO
    AccessioniPrimary (citable) accession number: O14160
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 4, 2008
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3