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O14160 (SYVM_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Valine--tRNA ligase, mitochondrial

EC=6.1.1.9
Alternative name(s):
Valyl-tRNA synthetase
Short name=ValRS
Gene names
Name:vas1
ORF Names:SPAC4A8.08c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length950 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).

Subcellular location

Mitochondrion Ref.2.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 9090Mitochondrion
Chain91 – 950860Valine--tRNA ligase, mitochondrial
PRO_0000352849

Regions

Motif67 – 7711"HIGH" region
Motif556 – 5605"KMSKS" region

Sites

Binding site5591ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O14160 [UniParc].

Last modified May 1, 1999. Version 2.
Checksum: 923B080350E3F40B

FASTA950109,627
        10         20         30         40         50         60 
MFHFQRSFSS RKAHGLLSFK NRNYIHIEAP FDIAAIQDGW NIIRKHIHYP KPKSIEAPMF 

        70         80         90        100        110        120 
PILLPPPNIT GKLHIGHALT ITIQDALARF YAMHGYKVSF RPGTDHAGIA TQSVVEKYLQ 

       130        140        150        160        170        180 
KKGVYRNQLS KDELLSSIHS WQVKYQKSII NQLKSFEAIF DWDNIFYTMD QNRSEAVNEA 

       190        200        210        220        230        240 
FISLFNAGLI YRANRFVNWC PKLESAVSDI EVESQQINKP VTKYVDNTPV EFGWLYEISY 

       250        260        270        280        290        300 
QLEGSDNEQL NVSTTRPETI FGDRAIAVSP HDERYKKYVG RFVKHPLIDD LLIPVICDNA 

       310        320        330        340        350        360 
VDRHFGTGVL KITPMHSIVD YEIAKRHNID CVSIMDKSGN LINCSKEVNG MNRLKARSKI 

       370        380        390        400        410        420 
VRLLQQRNRL VEQVPHSLIL SVCSRTGDVI EPVMVPQWYL SVDSLKKEVL KSSNKLKLVP 

       430        440        450        460        470        480 
SLARKEWDSW FKKMGDWCIS RQIWWGHQIP VWKILEEDKW IAAPNYEKAL QLSVGKSVSQ 

       490        500        510        520        530        540 
DSDVLDTWFS SALLPLSAFG WPKSKDIQPL PFIESGQDIL FFWIARMALL CKYFSNELPF 

       550        560        570        580        590        600 
KEIILHPLVR DSEGRKMSKS LGNVIDPMDI INGVTLENMK KALLEGNLPI SEVHKSSKQM 

       610        620        630        640        650        660 
EKAFPNGIPA QGIDIFRYGL FLCLHHEQRI LLDMNSFSDA HRFVSKLWNL ARYFNQYKDK 

       670        680        690        700        710        720 
ENPLKLTDSQ RQRISLLKMA TYSKLHHAVE GVKESFEQRK FFNAADIMKN FLLNDLSSVY 

       730        740        750        760        770        780 
VELTRFDVKD SKSSAYEVYR VFSDILHIFL KLIHPIVPCI SGVMLHSKII PERKNSEFLS 

       790        800        810        820        830        840 
FPTSQQECLL VHDNQAEVVV QNAYDVLIQL RKLESPLNKS PSREHTVYIS TSLEPLKYFY 

       850        860        870        880        890        900 
DAIEQSTNLK LKSISQEDTI DLMRNQTFIL SRISSDTILL VPKKLYPSKR KKLRKNLDDL 

       910        920        930        940        950 
QKKLDKIQHT TSSSGYEKAP SYIKLKNCEL QKDILVKIQD IKQALLNTEI 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAB38577.1.
PIRT38777.
RefSeqNP_593819.1. NM_001019249.2.

3D structure databases

ProteinModelPortalO14160.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid280018. 2 interactions.
MINTMINT-4671023.
STRING4896.SPAC4A8.08c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC4A8.08c.1; SPAC4A8.08c.1:pep; SPAC4A8.08c.
GeneID2543603.
KEGGspo:SPAC4A8.08c.

Organism-specific databases

PomBaseSPAC4A8.08c.

Phylogenomic databases

eggNOGCOG0525.
HOGENOMHOG000020094.
KOK01873.
OMAAEANTIM.
OrthoDBEOG7H1JTZ.
PhylomeDBO14160.

Family and domain databases

Gene3D1.10.730.10. 2 hits.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PANTHERPTHR11946:SF5. PTHR11946:SF5. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSPR00986. TRNASYNTHVAL.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00422. valS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804610.

Entry information

Entry nameSYVM_SCHPO
AccessionPrimary (citable) accession number: O14160
Entry history
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries