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O14160

- SYVM_SCHPO

UniProt

O14160 - SYVM_SCHPO

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Protein

Valine--tRNA ligase, mitochondrial

Gene

vas1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei559 – 5591ATPBy similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. valine-tRNA ligase activity Source: PomBase

GO - Biological processi

  1. mitochondrial valyl-tRNA aminoacylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Valine--tRNA ligase, mitochondrial (EC:6.1.1.9)
Alternative name(s):
Valyl-tRNA synthetase
Short name:
ValRS
Gene namesi
Name:vas1
ORF Names:SPAC4A8.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC4A8.08c.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 9090MitochondrionAdd
BLAST
Chaini91 – 950860Valine--tRNA ligase, mitochondrialPRO_0000352849Add
BLAST

Proteomic databases

MaxQBiO14160.

Interactioni

Protein-protein interaction databases

BioGridi280018. 2 interactions.
MINTiMINT-4671023.
STRINGi4896.SPAC4A8.08c-1.

Structurei

3D structure databases

ProteinModelPortaliO14160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi67 – 7711"HIGH" regionAdd
BLAST
Motifi556 – 5605"KMSKS" region

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0525.
HOGENOMiHOG000020094.
InParanoidiO14160.
KOiK01873.
OMAiAEANTIM.
OrthoDBiEOG7H1JTZ.
PhylomeDBiO14160.

Family and domain databases

Gene3Di1.10.730.10. 2 hits.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PANTHERiPTHR11946:SF5. PTHR11946:SF5. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14160-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFHFQRSFSS RKAHGLLSFK NRNYIHIEAP FDIAAIQDGW NIIRKHIHYP
60 70 80 90 100
KPKSIEAPMF PILLPPPNIT GKLHIGHALT ITIQDALARF YAMHGYKVSF
110 120 130 140 150
RPGTDHAGIA TQSVVEKYLQ KKGVYRNQLS KDELLSSIHS WQVKYQKSII
160 170 180 190 200
NQLKSFEAIF DWDNIFYTMD QNRSEAVNEA FISLFNAGLI YRANRFVNWC
210 220 230 240 250
PKLESAVSDI EVESQQINKP VTKYVDNTPV EFGWLYEISY QLEGSDNEQL
260 270 280 290 300
NVSTTRPETI FGDRAIAVSP HDERYKKYVG RFVKHPLIDD LLIPVICDNA
310 320 330 340 350
VDRHFGTGVL KITPMHSIVD YEIAKRHNID CVSIMDKSGN LINCSKEVNG
360 370 380 390 400
MNRLKARSKI VRLLQQRNRL VEQVPHSLIL SVCSRTGDVI EPVMVPQWYL
410 420 430 440 450
SVDSLKKEVL KSSNKLKLVP SLARKEWDSW FKKMGDWCIS RQIWWGHQIP
460 470 480 490 500
VWKILEEDKW IAAPNYEKAL QLSVGKSVSQ DSDVLDTWFS SALLPLSAFG
510 520 530 540 550
WPKSKDIQPL PFIESGQDIL FFWIARMALL CKYFSNELPF KEIILHPLVR
560 570 580 590 600
DSEGRKMSKS LGNVIDPMDI INGVTLENMK KALLEGNLPI SEVHKSSKQM
610 620 630 640 650
EKAFPNGIPA QGIDIFRYGL FLCLHHEQRI LLDMNSFSDA HRFVSKLWNL
660 670 680 690 700
ARYFNQYKDK ENPLKLTDSQ RQRISLLKMA TYSKLHHAVE GVKESFEQRK
710 720 730 740 750
FFNAADIMKN FLLNDLSSVY VELTRFDVKD SKSSAYEVYR VFSDILHIFL
760 770 780 790 800
KLIHPIVPCI SGVMLHSKII PERKNSEFLS FPTSQQECLL VHDNQAEVVV
810 820 830 840 850
QNAYDVLIQL RKLESPLNKS PSREHTVYIS TSLEPLKYFY DAIEQSTNLK
860 870 880 890 900
LKSISQEDTI DLMRNQTFIL SRISSDTILL VPKKLYPSKR KKLRKNLDDL
910 920 930 940 950
QKKLDKIQHT TSSSGYEKAP SYIKLKNCEL QKDILVKIQD IKQALLNTEI
Length:950
Mass (Da):109,627
Last modified:May 1, 1999 - v2
Checksum:i923B080350E3F40B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB38577.1.
PIRiT38777.
RefSeqiNP_593819.1. NM_001019249.2.

Genome annotation databases

EnsemblFungiiSPAC4A8.08c.1; SPAC4A8.08c.1:pep; SPAC4A8.08c.
GeneIDi2543603.
KEGGispo:SPAC4A8.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB38577.1 .
PIRi T38777.
RefSeqi NP_593819.1. NM_001019249.2.

3D structure databases

ProteinModelPortali O14160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 280018. 2 interactions.
MINTi MINT-4671023.
STRINGi 4896.SPAC4A8.08c-1.

Proteomic databases

MaxQBi O14160.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC4A8.08c.1 ; SPAC4A8.08c.1:pep ; SPAC4A8.08c .
GeneIDi 2543603.
KEGGi spo:SPAC4A8.08c.

Organism-specific databases

PomBasei SPAC4A8.08c.

Phylogenomic databases

eggNOGi COG0525.
HOGENOMi HOG000020094.
InParanoidi O14160.
KOi K01873.
OMAi AEANTIM.
OrthoDBi EOG7H1JTZ.
PhylomeDBi O14160.

Miscellaneous databases

NextBioi 20804610.

Family and domain databases

Gene3Di 1.10.730.10. 2 hits.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view ]
PANTHERi PTHR11946:SF5. PTHR11946:SF5. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
PRINTSi PR00986. TRNASYNTHVAL.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00422. valS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYVM_SCHPO
AccessioniPrimary (citable) accession number: O14160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3