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O14160

- SYVM_SCHPO

UniProt

O14160 - SYVM_SCHPO

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Protein

Valine--tRNA ligase, mitochondrial

Gene
vas1, SPAC4A8.08c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei559 – 5591ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. valine-tRNA ligase activity Source: PomBase

GO - Biological processi

  1. mitochondrial valyl-tRNA aminoacylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Valine--tRNA ligase, mitochondrial (EC:6.1.1.9)
Alternative name(s):
Valyl-tRNA synthetase
Short name:
ValRS
Gene namesi
Name:vas1
ORF Names:SPAC4A8.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC4A8.08c.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 9090MitochondrionAdd
BLAST
Chaini91 – 950860Valine--tRNA ligase, mitochondrialPRO_0000352849Add
BLAST

Proteomic databases

MaxQBiO14160.

Interactioni

Protein-protein interaction databases

BioGridi280018. 2 interactions.
MINTiMINT-4671023.
STRINGi4896.SPAC4A8.08c-1.

Structurei

3D structure databases

ProteinModelPortaliO14160.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi67 – 7711"HIGH" regionAdd
BLAST
Motifi556 – 5605"KMSKS" region

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0525.
HOGENOMiHOG000020094.
KOiK01873.
OMAiAEANTIM.
OrthoDBiEOG7H1JTZ.
PhylomeDBiO14160.

Family and domain databases

Gene3Di1.10.730.10. 2 hits.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PANTHERiPTHR11946:SF5. PTHR11946:SF5. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14160-1 [UniParc]FASTAAdd to Basket

« Hide

MFHFQRSFSS RKAHGLLSFK NRNYIHIEAP FDIAAIQDGW NIIRKHIHYP    50
KPKSIEAPMF PILLPPPNIT GKLHIGHALT ITIQDALARF YAMHGYKVSF 100
RPGTDHAGIA TQSVVEKYLQ KKGVYRNQLS KDELLSSIHS WQVKYQKSII 150
NQLKSFEAIF DWDNIFYTMD QNRSEAVNEA FISLFNAGLI YRANRFVNWC 200
PKLESAVSDI EVESQQINKP VTKYVDNTPV EFGWLYEISY QLEGSDNEQL 250
NVSTTRPETI FGDRAIAVSP HDERYKKYVG RFVKHPLIDD LLIPVICDNA 300
VDRHFGTGVL KITPMHSIVD YEIAKRHNID CVSIMDKSGN LINCSKEVNG 350
MNRLKARSKI VRLLQQRNRL VEQVPHSLIL SVCSRTGDVI EPVMVPQWYL 400
SVDSLKKEVL KSSNKLKLVP SLARKEWDSW FKKMGDWCIS RQIWWGHQIP 450
VWKILEEDKW IAAPNYEKAL QLSVGKSVSQ DSDVLDTWFS SALLPLSAFG 500
WPKSKDIQPL PFIESGQDIL FFWIARMALL CKYFSNELPF KEIILHPLVR 550
DSEGRKMSKS LGNVIDPMDI INGVTLENMK KALLEGNLPI SEVHKSSKQM 600
EKAFPNGIPA QGIDIFRYGL FLCLHHEQRI LLDMNSFSDA HRFVSKLWNL 650
ARYFNQYKDK ENPLKLTDSQ RQRISLLKMA TYSKLHHAVE GVKESFEQRK 700
FFNAADIMKN FLLNDLSSVY VELTRFDVKD SKSSAYEVYR VFSDILHIFL 750
KLIHPIVPCI SGVMLHSKII PERKNSEFLS FPTSQQECLL VHDNQAEVVV 800
QNAYDVLIQL RKLESPLNKS PSREHTVYIS TSLEPLKYFY DAIEQSTNLK 850
LKSISQEDTI DLMRNQTFIL SRISSDTILL VPKKLYPSKR KKLRKNLDDL 900
QKKLDKIQHT TSSSGYEKAP SYIKLKNCEL QKDILVKIQD IKQALLNTEI 950
Length:950
Mass (Da):109,627
Last modified:May 1, 1999 - v2
Checksum:i923B080350E3F40B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB38577.1.
PIRiT38777.
RefSeqiNP_593819.1. NM_001019249.2.

Genome annotation databases

EnsemblFungiiSPAC4A8.08c.1; SPAC4A8.08c.1:pep; SPAC4A8.08c.
GeneIDi2543603.
KEGGispo:SPAC4A8.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB38577.1 .
PIRi T38777.
RefSeqi NP_593819.1. NM_001019249.2.

3D structure databases

ProteinModelPortali O14160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 280018. 2 interactions.
MINTi MINT-4671023.
STRINGi 4896.SPAC4A8.08c-1.

Proteomic databases

MaxQBi O14160.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC4A8.08c.1 ; SPAC4A8.08c.1:pep ; SPAC4A8.08c .
GeneIDi 2543603.
KEGGi spo:SPAC4A8.08c.

Organism-specific databases

PomBasei SPAC4A8.08c.

Phylogenomic databases

eggNOGi COG0525.
HOGENOMi HOG000020094.
KOi K01873.
OMAi AEANTIM.
OrthoDBi EOG7H1JTZ.
PhylomeDBi O14160.

Miscellaneous databases

NextBioi 20804610.

Family and domain databases

Gene3Di 1.10.730.10. 2 hits.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view ]
PANTHERi PTHR11946:SF5. PTHR11946:SF5. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
PRINTSi PR00986. TRNASYNTHVAL.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00422. valS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSYVM_SCHPO
AccessioniPrimary (citable) accession number: O14160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3