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O14156 (PP2C4_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 2C homolog 4

Short name=PP2C-4
EC=3.1.3.16
Gene names
Name:ptc4
ORF Names:SPAC4A8.03c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a role in the regulation of vacuole fusion. Ref.1

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subunit structure

Monomer. Ref.1

Subcellular location

Vacuole membrane; Peripheral membrane protein Ref.1.

Sequence similarities

Belongs to the PP2C family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

sty1Q098924EBI-7593590,EBI-3648525

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 383383Protein phosphatase 2C homolog 4
PRO_0000057773

Sites

Metal binding921Manganese 1 By similarity
Metal binding921Manganese 2 By similarity
Metal binding3081Manganese 2 By similarity
Metal binding3471Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
O14156 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: 88E00C2BDAE4B9BF

FASTA38343,569
        10         20         30         40         50         60 
MSIRFLKRLR APLYIQNAYC SKNYFYRSFI QYYSPSNGPY LKISMNKAPQ SLGLCTARGD 

        70         80         90        100        110        120 
SPTNQDRMAY GYLNNLKDTT NRDSPFFYGL FDGHGGTECS EFLSTNLGKI IENQDLNDTE 

       130        140        150        160        170        180 
KILKEVHSVG GYMAGLKPPF SLRTVLQSRD EDLLWRARLY YSFLQADMDY LTNYARPSPD 

       190        200        210        220        230        240 
SAVPGAVGTV AIITSKNNLS YWESDSYIIH LAHVGDTRAL LCDSRTGRAH RLTFQHHPAD 

       250        260        270        280        290        300 
VEEARRLRRY NMGFSRDSFG QKRFAWVANT RSFGDGYKLK KLGVVAEPQL TSIHSLRDDW 

       310        320        330        340        350        360 
SFLTLLSDGI TDVVSDDEVV DIIKLSESPQ DAANNIIRYA QNVGAVDDIT CLVVRLPGWK 

       370        380 
KRTINDFTKN LRLEKSAYHP RRS 

« Hide

References

« Hide 'large scale' references
[1]"Vacuole fusion regulated by protein phosphatase 2C in fission yeast."
Gaits F., Russell P.
Mol. Biol. Cell 10:2647-2654(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBUNIT, SUBCELLULAR LOCATION, FUNCTION.
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF140285 Genomic DNA. Translation: AAD27651.1.
CU329670 Genomic DNA. Translation: CAB58554.1.
PIRT38772.
RefSeqNP_593814.1. NM_001019244.2.

3D structure databases

ProteinModelPortalO14156.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279527. 3 interactions.
IntActO14156. 2 interactions.
MINTMINT-4670968.
STRING4896.SPAC4A8.03c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC4A8.03c.1; SPAC4A8.03c.1:pep; SPAC4A8.03c.
GeneID2543095.
KEGGspo:SPAC4A8.03c.

Organism-specific databases

PomBaseSPAC4A8.03c.

Phylogenomic databases

eggNOGCOG0631.
OMAYLNGRIN.
OrthoDBEOG7Q8CZ1.
PhylomeDBO14156.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 2 hits.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804122.
PROO14156.

Entry information

Entry namePP2C4_SCHPO
AccessionPrimary (citable) accession number: O14156
Secondary accession number(s): Q9UR02
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 14, 2001
Last modified: April 16, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names