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Protein

Protein phosphatase 2C homolog 4

Gene

ptc4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in the regulation of vacuole fusion.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921Manganese 1By similarity
Metal bindingi92 – 921Manganese 2By similarity
Metal bindingi308 – 3081Manganese 2By similarity
Metal bindingi347 – 3471Manganese 2By similarity

GO - Molecular functioni

  1. magnesium-dependent protein serine/threonine phosphatase activity Source: PomBase
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of autophagic vacuole fusion Source: PomBase
  2. positive regulation of vacuole fusion, non-autophagic Source: PomBase
  3. protein dephosphorylation Source: PomBase
  4. regulation of vacuole fusion, non-autophagic Source: PomBase
  5. signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 4 (EC:3.1.3.16)
Short name:
PP2C-4
Gene namesi
Name:ptc4
ORF Names:SPAC4A8.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

PomBaseiSPAC4A8.03c.

Subcellular locationi

Vacuole membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. fungal-type vacuole membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Protein phosphatase 2C homolog 4PRO_0000057773Add
BLAST

Proteomic databases

MaxQBiO14156.

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
sty1Q098924EBI-7593590,EBI-3648525

Protein-protein interaction databases

BioGridi279527. 3 interactions.
IntActiO14156. 2 interactions.
MINTiMINT-4670968.
STRINGi4896.SPAC4A8.03c-1.

Structurei

3D structure databases

ProteinModelPortaliO14156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 356306PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0631.
InParanoidiO14156.
OMAiYLNGRIN.
OrthoDBiEOG7Q8CZ1.
PhylomeDBiO14156.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14156-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIRFLKRLR APLYIQNAYC SKNYFYRSFI QYYSPSNGPY LKISMNKAPQ
60 70 80 90 100
SLGLCTARGD SPTNQDRMAY GYLNNLKDTT NRDSPFFYGL FDGHGGTECS
110 120 130 140 150
EFLSTNLGKI IENQDLNDTE KILKEVHSVG GYMAGLKPPF SLRTVLQSRD
160 170 180 190 200
EDLLWRARLY YSFLQADMDY LTNYARPSPD SAVPGAVGTV AIITSKNNLS
210 220 230 240 250
YWESDSYIIH LAHVGDTRAL LCDSRTGRAH RLTFQHHPAD VEEARRLRRY
260 270 280 290 300
NMGFSRDSFG QKRFAWVANT RSFGDGYKLK KLGVVAEPQL TSIHSLRDDW
310 320 330 340 350
SFLTLLSDGI TDVVSDDEVV DIIKLSESPQ DAANNIIRYA QNVGAVDDIT
360 370 380
CLVVRLPGWK KRTINDFTKN LRLEKSAYHP RRS
Length:383
Mass (Da):43,569
Last modified:August 14, 2001 - v2
Checksum:i88E00C2BDAE4B9BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140285 Genomic DNA. Translation: AAD27651.1.
CU329670 Genomic DNA. Translation: CAB58554.1.
PIRiT38772.
RefSeqiNP_593814.1. NM_001019244.2.

Genome annotation databases

EnsemblFungiiSPAC4A8.03c.1; SPAC4A8.03c.1:pep; SPAC4A8.03c.
GeneIDi2543095.
KEGGispo:SPAC4A8.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140285 Genomic DNA. Translation: AAD27651.1.
CU329670 Genomic DNA. Translation: CAB58554.1.
PIRiT38772.
RefSeqiNP_593814.1. NM_001019244.2.

3D structure databases

ProteinModelPortaliO14156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279527. 3 interactions.
IntActiO14156. 2 interactions.
MINTiMINT-4670968.
STRINGi4896.SPAC4A8.03c-1.

Proteomic databases

MaxQBiO14156.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4A8.03c.1; SPAC4A8.03c.1:pep; SPAC4A8.03c.
GeneIDi2543095.
KEGGispo:SPAC4A8.03c.

Organism-specific databases

PomBaseiSPAC4A8.03c.

Phylogenomic databases

eggNOGiCOG0631.
InParanoidiO14156.
OMAiYLNGRIN.
OrthoDBiEOG7Q8CZ1.
PhylomeDBiO14156.

Miscellaneous databases

NextBioi20804122.
PROiO14156.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Vacuole fusion regulated by protein phosphatase 2C in fission yeast."
    Gaits F., Russell P.
    Mol. Biol. Cell 10:2647-2654(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBUNIT, SUBCELLULAR LOCATION, FUNCTION.
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPP2C4_SCHPO
AccessioniPrimary (citable) accession number: O14156
Secondary accession number(s): Q9UR02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 14, 2001
Last modified: April 1, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.