Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O14156

- PP2C4_SCHPO

UniProt

O14156 - PP2C4_SCHPO

Protein

Protein phosphatase 2C homolog 4

Gene

ptc4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Has a role in the regulation of vacuole fusion.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi92 – 921Manganese 1By similarity
    Metal bindingi92 – 921Manganese 2By similarity
    Metal bindingi308 – 3081Manganese 2By similarity
    Metal bindingi347 – 3471Manganese 2By similarity

    GO - Molecular functioni

    1. magnesium-dependent protein serine/threonine phosphatase activity Source: PomBase
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. cellular response to heat Source: PomBase
    2. positive regulation of autophagic vacuole fusion Source: PomBase
    3. positive regulation of vacuole fusion, non-autophagic Source: PomBase
    4. protein dephosphorylation Source: PomBase
    5. regulation of vacuole fusion, non-autophagic Source: PomBase
    6. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 2C homolog 4 (EC:3.1.3.16)
    Short name:
    PP2C-4
    Gene namesi
    Name:ptc4
    ORF Names:SPAC4A8.03c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC4A8.03c.

    Subcellular locationi

    Vacuole membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. fungal-type vacuole membrane Source: PomBase

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 383383Protein phosphatase 2C homolog 4PRO_0000057773Add
    BLAST

    Proteomic databases

    MaxQBiO14156.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    sty1Q098924EBI-7593590,EBI-3648525

    Protein-protein interaction databases

    BioGridi279527. 3 interactions.
    IntActiO14156. 2 interactions.
    MINTiMINT-4670968.
    STRINGi4896.SPAC4A8.03c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO14156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    OMAiYLNGRIN.
    OrthoDBiEOG7Q8CZ1.
    PhylomeDBiO14156.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14156-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIRFLKRLR APLYIQNAYC SKNYFYRSFI QYYSPSNGPY LKISMNKAPQ    50
    SLGLCTARGD SPTNQDRMAY GYLNNLKDTT NRDSPFFYGL FDGHGGTECS 100
    EFLSTNLGKI IENQDLNDTE KILKEVHSVG GYMAGLKPPF SLRTVLQSRD 150
    EDLLWRARLY YSFLQADMDY LTNYARPSPD SAVPGAVGTV AIITSKNNLS 200
    YWESDSYIIH LAHVGDTRAL LCDSRTGRAH RLTFQHHPAD VEEARRLRRY 250
    NMGFSRDSFG QKRFAWVANT RSFGDGYKLK KLGVVAEPQL TSIHSLRDDW 300
    SFLTLLSDGI TDVVSDDEVV DIIKLSESPQ DAANNIIRYA QNVGAVDDIT 350
    CLVVRLPGWK KRTINDFTKN LRLEKSAYHP RRS 383
    Length:383
    Mass (Da):43,569
    Last modified:August 14, 2001 - v2
    Checksum:i88E00C2BDAE4B9BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF140285 Genomic DNA. Translation: AAD27651.1.
    CU329670 Genomic DNA. Translation: CAB58554.1.
    PIRiT38772.
    RefSeqiNP_593814.1. NM_001019244.2.

    Genome annotation databases

    EnsemblFungiiSPAC4A8.03c.1; SPAC4A8.03c.1:pep; SPAC4A8.03c.
    GeneIDi2543095.
    KEGGispo:SPAC4A8.03c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF140285 Genomic DNA. Translation: AAD27651.1 .
    CU329670 Genomic DNA. Translation: CAB58554.1 .
    PIRi T38772.
    RefSeqi NP_593814.1. NM_001019244.2.

    3D structure databases

    ProteinModelPortali O14156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279527. 3 interactions.
    IntActi O14156. 2 interactions.
    MINTi MINT-4670968.
    STRINGi 4896.SPAC4A8.03c-1.

    Proteomic databases

    MaxQBi O14156.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC4A8.03c.1 ; SPAC4A8.03c.1:pep ; SPAC4A8.03c .
    GeneIDi 2543095.
    KEGGi spo:SPAC4A8.03c.

    Organism-specific databases

    PomBasei SPAC4A8.03c.

    Phylogenomic databases

    eggNOGi COG0631.
    OMAi YLNGRIN.
    OrthoDBi EOG7Q8CZ1.
    PhylomeDBi O14156.

    Miscellaneous databases

    NextBioi 20804122.
    PROi O14156.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vacuole fusion regulated by protein phosphatase 2C in fission yeast."
      Gaits F., Russell P.
      Mol. Biol. Cell 10:2647-2654(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBUNIT, SUBCELLULAR LOCATION, FUNCTION.
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPP2C4_SCHPO
    AccessioniPrimary (citable) accession number: O14156
    Secondary accession number(s): Q9UR02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3