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Protein

ATP-dependent DNA helicase chl1

Gene

chl1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • DNA-dependent DNA replication maintenance of fidelity Source: PomBase
  • interstrand cross-link repair Source: PomBase

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processCell cycle
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent DNA helicase chl1By similarity (EC:3.6.4.12By similarity)
Alternative name(s):
Chromosome loss protein 1By similarity
Gene namesi
Name:chl1
ORF Names:SPAC3G6.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3G6.11
PomBaseiSPAC3G6.11 chl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003510161 – 844ATP-dependent DNA helicase chl1Add BLAST844

Proteomic databases

PaxDbiO14147
PRIDEiO14147

Interactioni

Protein-protein interaction databases

BioGridi279550, 24 interactors
STRINGi4896.SPAC3G6.11.1

Structurei

3D structure databases

ProteinModelPortaliO14147
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 418Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST410

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi362 – 365DEAH box4

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000241266
InParanoidiO14147
KOiK11273
OMAiFKVQRYC
OrthoDBiEOG092C10ZG
PhylomeDBiO14147

Family and domain databases

InterProiView protein in InterPro
IPR006555 ATP-dep_Helicase_C
IPR010614 DEAD_2
IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554 Helicase-like_DEXD_c2
IPR027417 P-loop_NTPase
IPR013020 Rad3/Chl1-like
PfamiView protein in Pfam
PF06733 DEAD_2, 1 hit
PF13307 Helicase_C_2, 1 hit
SMARTiView protein in SMART
SM00488 DEXDc2, 1 hit
SM00491 HELICc2, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
TIGRFAMsiTIGR00604 rad3, 1 hit
PROSITEiView protein in PROSITE
PS51193 HELICASE_ATP_BIND_2, 1 hit

Sequencei

Sequence statusi: Complete.

O14147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHSKEVKFK TNFHHPYTPY DIQLEFMRSL YSSISDGKIG IFESPTGTGK
60 70 80 90 100
SLSLICASLT WLDEHGGVLL EDNEKSNDNK SNTSSKIPDW VLEQDLKIQK
110 120 130 140 150
DLVKETHARL EQRLEEIRKR NQSRKNQMSN NSTTYHRETK RRNINAEAST
160 170 180 190 200
SDNCNNSNTS VDPMDEYLVT AEYTMPSTSE QSEDLFNNGY SSKVSELLRK
210 220 230 240 250
LSPDNEKPPI VQKIYFTSRT HSQLQQLVQE IKKLNNQTFS TPIRVVSLAS
260 270 280 290 300
RKNLCINNEV RKLRPTSALN EKCIELQGSA HKCPFLQDNT QLWDFRDEAL
310 320 330 340 350
AEIMDIEELV ELGQRLKVCP YYGTREAVDS AQIVTLPYPL LLQESARNAL
360 370 380 390 400
NLTLKDNICI IDEAHNLIDA ICSMHSSSIS FRQVCIAETQ LQQYFLRFEK
410 420 430 440 450
RLNGNNRMHI KQLIKVVYNL KSFFLNCLET NTNSKVINVD SLLVSNGADQ
460 470 480 490 500
INLHHLSEYL NVSKLARKVD GYTKYMHSLG TQELESLNDL RSERFSNGNG
510 520 530 540 550
YEEDPYTPVL MQLESFLLNI ANPAPEGKLF YEKQTGDNPY LKYLLLDPSK
560 570 580 590 600
HVEILTEQCR SVNLAGGTMS PIDDFITLLF SDEQSRILPF SCDHIVPPEN
610 620 630 640 650
ITTILVSQGP AGVPFEFTHK RKDDENLLKD LGRTFQNFIS IIPDGVVVFF
660 670 680 690 700
PSFAFLQQAV KVWEMNGITN RLNAKKPLFI ESKDFGDNPL DTFEHYKQSV
710 720 730 740 750
DAGLSGMLFS VIGGRLSEGI NFSDKLGRAV MVVGMPFPNS QDVEWQAKVS
760 770 780 790 800
YVEEKAKEKG INAKQASQEF YENTCMRAVN QSIGRAIRHR DDYASIILLD
810 820 830 840
SRYNRSSIQR KLPNWLSKNI HSSPNFGPAI RQLATFFRAK KMCD
Length:844
Mass (Da):96,204
Last modified:January 1, 1998 - v1
Checksum:i19232A24457F12A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16287.1
PIRiT38730
RefSeqiNP_594977.1, NM_001020408.2

Genome annotation databases

EnsemblFungiiSPAC3G6.11.1; SPAC3G6.11.1:pep; SPAC3G6.11
GeneIDi2543118
KEGGispo:SPAC3G6.11

Similar proteinsi

Entry informationi

Entry nameiCHL1_SCHPO
AccessioniPrimary (citable) accession number: O14147
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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