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Protein

ATP-dependent DNA helicase chl1

Gene

chl1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • DNA-dependent DNA replication maintenance of fidelity Source: PomBase
  • interstrand cross-link repair Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent DNA helicase chl1By similarity (EC:3.6.4.12By similarity)
Alternative name(s):
Chromosome loss protein 1By similarity
Gene namesi
Name:chl1
ORF Names:SPAC3G6.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3G6.11.
PomBaseiSPAC3G6.11. chl1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • site of double-strand break Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003510161 – 844ATP-dependent DNA helicase chl1Add BLAST844

Proteomic databases

PRIDEiO14147.

Interactioni

Protein-protein interaction databases

BioGridi279550. 23 interactors.
MINTiMINT-4670915.

Structurei

3D structure databases

ProteinModelPortaliO14147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 418Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST410

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi362 – 365DEAH box4

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000241266.
InParanoidiO14147.
KOiK11273.
OMAiKQLCINP.
OrthoDBiEOG092C10ZG.
PhylomeDBiO14147.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
SMARTiSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiPS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHSKEVKFK TNFHHPYTPY DIQLEFMRSL YSSISDGKIG IFESPTGTGK
60 70 80 90 100
SLSLICASLT WLDEHGGVLL EDNEKSNDNK SNTSSKIPDW VLEQDLKIQK
110 120 130 140 150
DLVKETHARL EQRLEEIRKR NQSRKNQMSN NSTTYHRETK RRNINAEAST
160 170 180 190 200
SDNCNNSNTS VDPMDEYLVT AEYTMPSTSE QSEDLFNNGY SSKVSELLRK
210 220 230 240 250
LSPDNEKPPI VQKIYFTSRT HSQLQQLVQE IKKLNNQTFS TPIRVVSLAS
260 270 280 290 300
RKNLCINNEV RKLRPTSALN EKCIELQGSA HKCPFLQDNT QLWDFRDEAL
310 320 330 340 350
AEIMDIEELV ELGQRLKVCP YYGTREAVDS AQIVTLPYPL LLQESARNAL
360 370 380 390 400
NLTLKDNICI IDEAHNLIDA ICSMHSSSIS FRQVCIAETQ LQQYFLRFEK
410 420 430 440 450
RLNGNNRMHI KQLIKVVYNL KSFFLNCLET NTNSKVINVD SLLVSNGADQ
460 470 480 490 500
INLHHLSEYL NVSKLARKVD GYTKYMHSLG TQELESLNDL RSERFSNGNG
510 520 530 540 550
YEEDPYTPVL MQLESFLLNI ANPAPEGKLF YEKQTGDNPY LKYLLLDPSK
560 570 580 590 600
HVEILTEQCR SVNLAGGTMS PIDDFITLLF SDEQSRILPF SCDHIVPPEN
610 620 630 640 650
ITTILVSQGP AGVPFEFTHK RKDDENLLKD LGRTFQNFIS IIPDGVVVFF
660 670 680 690 700
PSFAFLQQAV KVWEMNGITN RLNAKKPLFI ESKDFGDNPL DTFEHYKQSV
710 720 730 740 750
DAGLSGMLFS VIGGRLSEGI NFSDKLGRAV MVVGMPFPNS QDVEWQAKVS
760 770 780 790 800
YVEEKAKEKG INAKQASQEF YENTCMRAVN QSIGRAIRHR DDYASIILLD
810 820 830 840
SRYNRSSIQR KLPNWLSKNI HSSPNFGPAI RQLATFFRAK KMCD
Length:844
Mass (Da):96,204
Last modified:January 1, 1998 - v1
Checksum:i19232A24457F12A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16287.1.
PIRiT38730.
RefSeqiNP_594977.1. NM_001020408.2.

Genome annotation databases

EnsemblFungiiSPAC3G6.11.1; SPAC3G6.11.1:pep; SPAC3G6.11.
GeneIDi2543118.
KEGGispo:SPAC3G6.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16287.1.
PIRiT38730.
RefSeqiNP_594977.1. NM_001020408.2.

3D structure databases

ProteinModelPortaliO14147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279550. 23 interactors.
MINTiMINT-4670915.

Proteomic databases

PRIDEiO14147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC3G6.11.1; SPAC3G6.11.1:pep; SPAC3G6.11.
GeneIDi2543118.
KEGGispo:SPAC3G6.11.

Organism-specific databases

EuPathDBiFungiDB:SPAC3G6.11.
PomBaseiSPAC3G6.11. chl1.

Phylogenomic databases

HOGENOMiHOG000241266.
InParanoidiO14147.
KOiK11273.
OMAiKQLCINP.
OrthoDBiEOG092C10ZG.
PhylomeDBiO14147.

Miscellaneous databases

PROiO14147.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
SMARTiSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiPS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHL1_SCHPO
AccessioniPrimary (citable) accession number: O14147
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.