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Protein

Trehalose-phosphatase

Gene

tps2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphatase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process.

Catalytic activityi

Trehalose 6-phosphate + H2O = trehalose + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Protein family/group databases

CAZyiGT20 Glycosyltransferase Family 20

Names & Taxonomyi

Protein namesi
Recommended name:
Trehalose-phosphatase (EC:3.1.3.12)
Alternative name(s):
Trehalose synthase complex catalytic subunit tps2
Trehalose-6-phosphate phosphatase
Short name:
TPP
Gene namesi
Name:tps2
ORF Names:SPAC3G6.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3G6.09c
PomBaseiSPAC3G6.09c tps2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003162321 – 849Trehalose-phosphataseAdd BLAST849

Proteomic databases

MaxQBiO14145
PaxDbiO14145
PRIDEiO14145

PTM databases

iPTMnetiO14145

Interactioni

Protein-protein interaction databases

BioGridi279541, 23 interactors
STRINGi4896.SPAC3G6.09c.1

Structurei

3D structure databases

ProteinModelPortaliO14145
SMRiO14145
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 558GlycosyltransferaseBy similarityAdd BLAST558

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
In the C-terminal section; belongs to the trehalose phosphatase family.Curated

Phylogenomic databases

HOGENOMiHOG000191477
InParanoidiO14145
KOiK16055
OMAiFEHARHF
OrthoDBiEOG092C0LDC
PhylomeDBiO14145

Family and domain databases

CDDicd03788 GT1_TPS, 1 hit
Gene3Di3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR001830 Glyco_trans_20
IPR036412 HAD-like_sf
IPR006379 HAD-SF_hydro_IIB
IPR023214 HAD_sf
IPR003337 Trehalose_PPase
PfamiView protein in Pfam
PF00982 Glyco_transf_20, 1 hit
PF02358 Trehalose_PPase, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01484 HAD-SF-IIB, 1 hit
TIGR00685 T6PP, 1 hit

Sequencei

Sequence statusi: Complete.

O14145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSGAQGNTQ SAAYKRIVNV SRNFQFKAAL NKDTREWTFQ HRSSGTALYS
60 70 80 90 100
AIASLGDPSS PWDAVYVASP GPVQISEGND HTVETKIDEA AVVHRSSSIV
110 120 130 140 150
ISPEDQEIFL KKATEYYRKK NIEADIVPVW GKVQRVPQAK SSSATITPSV
160 170 180 190 200
SNKLSTAYQS IKSEALKDGP MYADSVLWDV LHYRIPTLDG YQQHNLWKNF
210 220 230 240 250
TRWSQYFADN IVSNYRPGDL ILIHDYSLFL LPRLIRKQLS DAPIVFFLHA
260 270 280 290 300
PFCTSEVFRC LSKRAEILKG VLASNVIAMQ TDSYTRHFLS TCSNVLGLET
310 320 330 340 350
TSTHIDTSDG FRVVVFSSHV SIDVPRVYSR CNSKPVSLKI QQLKSLYPSD
360 370 380 390 400
KKLIVGRDQL TKACGVTHKL RAFRELLIHF PKWRGHVVLI QITSLPVGNN
410 420 430 440 450
YSNEELKKTE NLVAQINSEF GSLDYTPVIH FHQLLDPDEY YALLSVANIA
460 470 480 490 500
CVSSVRDSMN TMALEYVACQ QKNKGSLILS EFSGTAELLL SAYLVNPYDY
510 520 530 540 550
SRFAETINYC LNMTEKERER RFSSLWKQAT SQSSQQWIYK LINRAAYEVK
560 570 580 590 600
ALESHMTTPL LTYNILIKPY RNAKRRLFLL DYDGTLIESA RNSIDAVPTD
610 620 630 640 650
RLLRTLKRLA SDSRNIVWIL SGRSQKFMEE WMGDISELGL SSEHGSAIRP
660 670 680 690 700
PLAGSWSSCA ENLDLSWKDT VRDFFQYYVE RTPGSYIEEK KHSISWCYQN
710 720 730 740 750
ANTTYSKFQS LECQTNLEDM LKHYDVEISP AKSFLEVHPN YLNKGSIVRR
760 770 780 790 800
ILKRSGSVDF VFCAGDDKTD ENMFEVFLPT AFSNSHLIDE IDSTEYSGSH
810 820 830 840
HTDDNSDANK VENVKVATFR VHIGLTDKPT LSDYHLPAPR DLGELLHNL
Length:849
Mass (Da):96,341
Last modified:January 1, 1998 - v1
Checksum:i6C7F74E43A6EBDFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16285.1
PIRiT38728
RefSeqiNP_594975.1, NM_001020406.2

Genome annotation databases

EnsemblFungiiSPAC3G6.09c.1; SPAC3G6.09c.1:pep; SPAC3G6.09c
GeneIDi2543109
KEGGispo:SPAC3G6.09c

Similar proteinsi

Entry informationi

Entry nameiTPS2_SCHPO
AccessioniPrimary (citable) accession number: O14145
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health