ID   ERV1_SCHPO              Reviewed;         182 AA.
AC   O14144;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 44.
DE   RecName: Full=Mitochondrial FAD-linked sulfhydryl oxidase erv1;
DE            EC=1.8.3.2;
GN   Name=erv1; ORFNames=SPAC3G6.08;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: FAD-dependent sulfhydryl oxidase that catalyzes
CC       disulfide bond formation. Required for the import and folding of
CC       small cysteine-containing proteins in the mitochondrial
CC       intermembrane space (IMS) (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2
CC       H(2)O.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space (By
CC       similarity).
CC   -!- SIMILARITY: Contains 1 ERV/ALR sulfhydryl oxidase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CU329670; CAB16284.1; -; Genomic_DNA.
DR   PIR; T38727; T38727.
DR   RefSeq; NP_594974.1; -.
DR   HSSP; Q63042; 1OQC.
DR   GeneID; 2543175; -.
DR   KEGG; spo:SPAC3G6.08; -.
DR   GeneDB_Spombe; SPAC3G6.08; -.
DR   OMA; O14144; GRSTWTF.
DR   ArrayExpress; O14144; -.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR   GO; GO:0016972; F:thiol oxidase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR017905; ERV/ALR_sulphydryl_oxidase.
DR   InterPro; IPR006863; Evr1_Alr.
DR   Gene3D; G3DSA:1.20.120.310; Evr1_Alr; 1.
DR   Pfam; PF04777; Evr1_Alr; 1.
DR   PROSITE; PS51324; ERV_ALR; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; FAD; Flavoprotein; Mitochondrion;
KW   Oxidoreductase.
FT   CHAIN         1    182       Mitochondrial FAD-linked sulfhydryl
FT                                oxidase erv1.
FT                                /FTId=PRO_0000339121.
FT   DOMAIN       75    177       ERV/ALR sulfhydryl oxidase.
FT   REGION      160    177       FAD-binding (By similarity).
FT   DISULFID    122    125       Redox-active (By similarity).
FT   DISULFID    153    170       By similarity.
SQ   SEQUENCE   182 AA;  20769 MW;  C8756CB2022F4746 CRC64;
     MVFGKRYRDK ETGIIYDENG RPCKTCNIFS SFRNVAQQPN SSTVPEVKSN TQLESKQSSI
     DCNTNAIPDS VSFPRLPDVA ELGRSTWTFL HAMAANFPKN PTPTQQNDMS SFLYNFSKFY
     PCWSCAEDLR IWMAKYGNSP RVDSRESLCE WICEAHNDVN ERLGKPLFNC QVWSKKASEL
     AD
//