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O14144

- ERV1_SCHPO

UniProt

O14144 - ERV1_SCHPO

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Protein
Mitochondrial FAD-linked sulfhydryl oxidase erv1
Gene
erv1, SPAC3G6.08
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS) By similarity.

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FAD By similarity.

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: PomBase
  2. thiol oxidase activity Source: PomBase

GO - Biological processi

  1. cellular iron ion homeostasis Source: PomBase
  2. mitochondrion organization Source: PomBase
  3. protein folding Source: GOC
  4. protein import into mitochondrial intermembrane space Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial FAD-linked sulfhydryl oxidase erv1 (EC:1.8.3.2)
Gene namesi
Name:erv1
ORF Names:SPAC3G6.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC3G6.08.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial intermembrane space Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Mitochondrial FAD-linked sulfhydryl oxidase erv1
PRO_0000339121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi122 ↔ 125Redox-active By similarity
Disulfide bondi153 ↔ 170 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO14144.

Interactioni

Protein-protein interaction databases

MINTiMINT-4670891.
STRINGi4896.SPAC3G6.08-1.

Structurei

3D structure databases

ProteinModelPortaliO14144.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 177103ERV/ALR sulfhydryl oxidase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni160 – 17718FAD-binding By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5054.
HOGENOMiHOG000195924.
KOiK17783.
OMAiNLWKKRW.
OrthoDBiEOG7WDNCT.
PhylomeDBiO14144.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
[Graphical view]
SUPFAMiSSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14144-1 [UniParc]FASTAAdd to Basket

« Hide

MVFGKRYRDK ETGIIYDENG RPCKTCNIFS SFRNVAQQPN SSTVPEVKSN    50
TQLESKQSSI DCNTNAIPDS VSFPRLPDVA ELGRSTWTFL HAMAANFPKN 100
PTPTQQNDMS SFLYNFSKFY PCWSCAEDLR IWMAKYGNSP RVDSRESLCE 150
WICEAHNDVN ERLGKPLFNC QVWSKKASEL AD 182
Length:182
Mass (Da):20,769
Last modified:January 1, 1998 - v1
Checksum:iC8756CB2022F4746
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB16284.1.
PIRiT38727.
RefSeqiNP_594974.1. NM_001020405.2.

Genome annotation databases

EnsemblFungiiSPAC3G6.08.1; SPAC3G6.08.1:pep; SPAC3G6.08.
GeneIDi2543175.
KEGGispo:SPAC3G6.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAB16284.1 .
PIRi T38727.
RefSeqi NP_594974.1. NM_001020405.2.

3D structure databases

ProteinModelPortali O14144.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4670891.
STRINGi 4896.SPAC3G6.08-1.

Proteomic databases

MaxQBi O14144.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC3G6.08.1 ; SPAC3G6.08.1:pep ; SPAC3G6.08 .
GeneIDi 2543175.
KEGGi spo:SPAC3G6.08.

Organism-specific databases

PomBasei SPAC3G6.08.

Phylogenomic databases

eggNOGi COG5054.
HOGENOMi HOG000195924.
KOi K17783.
OMAi NLWKKRW.
OrthoDBi EOG7WDNCT.
PhylomeDBi O14144.

Miscellaneous databases

NextBioi 20804200.
PROi O14144.

Family and domain databases

Gene3Di 1.20.120.310. 1 hit.
InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
[Graphical view ]
Pfami PF04777. Evr1_Alr. 1 hit.
[Graphical view ]
SUPFAMi SSF69000. SSF69000. 1 hit.
PROSITEi PS51324. ERV_ALR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiERV1_SCHPO
AccessioniPrimary (citable) accession number: O14144
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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