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Protein

Mitochondrial FAD-linked sulfhydryl oxidase erv1

Gene

erv1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS) (By similarity).PROSITE-ProRule annotation

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FADPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial FAD-linked sulfhydryl oxidase erv1 (EC:1.8.3.2)
Gene namesi
Name:erv1
ORF Names:SPAC3G6.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3G6.08
PomBaseiSPAC3G6.08 erv1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003391211 – 182Mitochondrial FAD-linked sulfhydryl oxidase erv1Add BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi122 ↔ 125Redox-activePROSITE-ProRule annotation
Disulfide bondi153 ↔ 170PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO14144
PaxDbiO14144
PRIDEiO14144

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC3G6.08.1

Structurei

3D structure databases

ProteinModelPortaliO14144
SMRiO14144
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 177ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni160 – 177FAD-bindingBy similarityAdd BLAST18

Phylogenomic databases

HOGENOMiHOG000195924
InParanoidiO14144
KOiK17783
OMAiLCDAHNE
OrthoDBiEOG092C3SAY
PhylomeDBiO14144

Family and domain databases

Gene3Di1.20.120.310, 1 hit
InterProiView protein in InterPro
IPR036774 ERV/ALR_sulphydryl_oxid_sf
IPR017905 ERV/ALR_sulphydryl_oxidase
PfamiView protein in Pfam
PF04777 Evr1_Alr, 1 hit
SUPFAMiSSF69000 SSF69000, 1 hit
PROSITEiView protein in PROSITE
PS51324 ERV_ALR, 1 hit

Sequencei

Sequence statusi: Complete.

O14144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFGKRYRDK ETGIIYDENG RPCKTCNIFS SFRNVAQQPN SSTVPEVKSN
60 70 80 90 100
TQLESKQSSI DCNTNAIPDS VSFPRLPDVA ELGRSTWTFL HAMAANFPKN
110 120 130 140 150
PTPTQQNDMS SFLYNFSKFY PCWSCAEDLR IWMAKYGNSP RVDSRESLCE
160 170 180
WICEAHNDVN ERLGKPLFNC QVWSKKASEL AD
Length:182
Mass (Da):20,769
Last modified:January 1, 1998 - v1
Checksum:iC8756CB2022F4746
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16284.1
PIRiT38727
RefSeqiNP_594974.1, NM_001020405.2

Genome annotation databases

EnsemblFungiiSPAC3G6.08.1; SPAC3G6.08.1:pep; SPAC3G6.08
GeneIDi2543175
KEGGispo:SPAC3G6.08

Similar proteinsi

Entry informationi

Entry nameiERV1_SCHPO
AccessioniPrimary (citable) accession number: O14144
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health