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O14144

- ERV1_SCHPO

UniProt

O14144 - ERV1_SCHPO

Protein

Mitochondrial FAD-linked sulfhydryl oxidase erv1

Gene

erv1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS) By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

    Cofactori

    FAD.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: PomBase
    2. thiol oxidase activity Source: PomBase

    GO - Biological processi

    1. cellular iron ion homeostasis Source: PomBase
    2. mitochondrion organization Source: PomBase
    3. protein folding Source: GOC
    4. protein import into mitochondrial intermembrane space Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial FAD-linked sulfhydryl oxidase erv1 (EC:1.8.3.2)
    Gene namesi
    Name:erv1
    ORF Names:SPAC3G6.08
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC3G6.08.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 182182Mitochondrial FAD-linked sulfhydryl oxidase erv1PRO_0000339121Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi122 ↔ 125Redox-activePROSITE-ProRule annotation
    Disulfide bondi153 ↔ 170PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiO14144.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4670891.
    STRINGi4896.SPAC3G6.08-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO14144.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini75 – 177103ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni160 – 17718FAD-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5054.
    HOGENOMiHOG000195924.
    KOiK17783.
    OMAiNLWKKRW.
    OrthoDBiEOG7WDNCT.
    PhylomeDBiO14144.

    Family and domain databases

    Gene3Di1.20.120.310. 1 hit.
    InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
    [Graphical view]
    PfamiPF04777. Evr1_Alr. 1 hit.
    [Graphical view]
    SUPFAMiSSF69000. SSF69000. 1 hit.
    PROSITEiPS51324. ERV_ALR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14144-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFGKRYRDK ETGIIYDENG RPCKTCNIFS SFRNVAQQPN SSTVPEVKSN    50
    TQLESKQSSI DCNTNAIPDS VSFPRLPDVA ELGRSTWTFL HAMAANFPKN 100
    PTPTQQNDMS SFLYNFSKFY PCWSCAEDLR IWMAKYGNSP RVDSRESLCE 150
    WICEAHNDVN ERLGKPLFNC QVWSKKASEL AD 182
    Length:182
    Mass (Da):20,769
    Last modified:January 1, 1998 - v1
    Checksum:iC8756CB2022F4746
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16284.1.
    PIRiT38727.
    RefSeqiNP_594974.1. NM_001020405.2.

    Genome annotation databases

    EnsemblFungiiSPAC3G6.08.1; SPAC3G6.08.1:pep; SPAC3G6.08.
    GeneIDi2543175.
    KEGGispo:SPAC3G6.08.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16284.1 .
    PIRi T38727.
    RefSeqi NP_594974.1. NM_001020405.2.

    3D structure databases

    ProteinModelPortali O14144.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4670891.
    STRINGi 4896.SPAC3G6.08-1.

    Proteomic databases

    MaxQBi O14144.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC3G6.08.1 ; SPAC3G6.08.1:pep ; SPAC3G6.08 .
    GeneIDi 2543175.
    KEGGi spo:SPAC3G6.08.

    Organism-specific databases

    PomBasei SPAC3G6.08.

    Phylogenomic databases

    eggNOGi COG5054.
    HOGENOMi HOG000195924.
    KOi K17783.
    OMAi NLWKKRW.
    OrthoDBi EOG7WDNCT.
    PhylomeDBi O14144.

    Miscellaneous databases

    NextBioi 20804200.
    PROi O14144.

    Family and domain databases

    Gene3Di 1.20.120.310. 1 hit.
    InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
    [Graphical view ]
    Pfami PF04777. Evr1_Alr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69000. SSF69000. 1 hit.
    PROSITEi PS51324. ERV_ALR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiERV1_SCHPO
    AccessioniPrimary (citable) accession number: O14144
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3