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Protein

Chromodomain helicase hrp3

Gene

hrp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in heterochromatin silencing. Required for transcriptional repression at the silence loci of mat3, where it has a direct role as a chromatin remodeling factor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi400 – 407ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • ATP-dependent chromatin remodeling Source: InterPro
  • chromatin remodeling Source: PomBase
  • chromatin silencing at silent mating-type cassette Source: PomBase
  • nucleosome organization Source: PomBase
  • regulation of nucleosome density Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase, Repressor
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain helicase hrp3 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase hrp3
Gene namesi
Name:hrp3
ORF Names:SPAC3G6.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3G6.01
PomBaseiSPAC3G6.01 hrp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802421 – 1388Chromodomain helicase hrp3Add BLAST1388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1250Phosphoserine1 Publication1
Modified residuei1285Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14139
PaxDbiO14139
PRIDEiO14139

PTM databases

iPTMnetiO14139
SwissPalmiO14139

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
swi6P403812EBI-7414157,EBI-926939

Protein-protein interaction databases

BioGridi279497, 290 interactors
IntActiO14139, 3 interactors
MINTiO14139
STRINGi4896.SPAC3G6.01.1

Structurei

3D structure databases

ProteinModelPortaliO14139
SMRiO14139
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 260Chromo 1PROSITE-ProRule annotationAdd BLAST70
Domaini288 – 349Chromo 2PROSITE-ProRule annotationAdd BLAST62
Domaini387 – 557Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST171
Domaini694 – 852Helicase C-terminalPROSITE-ProRule annotationAdd BLAST159

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi508 – 511DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi169 – 175Poly-Glu7
Compositional biasi947 – 950Poly-Glu4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000207917
InParanoidiO14139
KOiK11367
OMAiYEWQFEG
OrthoDBiEOG092C1YH4
PhylomeDBiO14139

Family and domain databases

CDDicd00024 CHROMO, 2 hits
cd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR037780 CHD1
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
IPR025260 DUF4208
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PANTHERiPTHR10799:SF838 PTHR10799:SF838, 1 hit
PfamiView protein in Pfam
PF00385 Chromo, 2 hits
PF13907 DUF4208, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 2 hits
SM00487 DEXDc, 1 hit
SM01176 DUF4208, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF54160 SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 2 hits
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

O14139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSAIALAL SSSKAIEQLD HVQTETPNLK QEMSESPSNS GVASKRKLQS
60 70 80 90 100
TEWLDPELYG LRRSGRTRSN PGRYVDTDDQ EDVFPSKHRK GTRNGSSFSR
110 120 130 140 150
HRTIRDLDDE AESVTSEESE SDDSSYGGTP KKRSRQKKSN TYVQDEIRFS
160 170 180 190 200
SRNSKGVNYN EDAYFESFEE EEEEEMYEYA TEVSEEPEDT RAIDVVLDHR
210 220 230 240 250
LIEGHDGSTP SEDYEFLIKW VNFSHLHCTW EPYNNISMIR GSKKVDNHIK
260 270 280 290 300
QVILLDREIR EDPTTTREDI EAMDIEKERK RENYEEYKQV DRIVAKHLNS
310 320 330 340 350
DGSVEYLVKW KQLLYDFCTW EASSIIEPIA ATEIQAFQER EESALSPSRG
360 370 380 390 400
TNYGNSRPKY RKLEQQPSYI TGGELRDFQL TGVNWMAYLW HKNENGILAD
410 420 430 440 450
EMGLGKTVQT VAFLSYLAHS LRQHGPFLVV VPLSTVPAWQ ETLALWASDM
460 470 480 490 500
NCISYLGNTT SRQVIRDYEF YVDGTQKIKF NLLLTTYEYV LKDRSVLSNI
510 520 530 540 550
KWQYMAIDEA HRLKNSESSL YEALSQFKNS NRLLITGTPL QNNIRELAAL
560 570 580 590 600
VDFLMPGKFE IREEINLEAP DEEQEAYIRS LQEHLQPYIL RRLKKDVEKS
610 620 630 640 650
LPSKSERILR VELSDLQMYW YKNILTRNYR VLTQSISSGS QISLLNIVVE
660 670 680 690 700
LKKASNHPYL FDGVEESWMQ KINSQGRRDE VLKGLIMNSG KMVLLDKLLS
710 720 730 740 750
RLRRDGHRVL IFSQMVRMLD ILGDYLSLRG YPHQRLDGTV PAAVRRTSID
760 770 780 790 800
HFNAPNSPDF VFLLSTRAGG LGINLMTADT VIIFDSDWNP QADLQAMARA
810 820 830 840 850
HRIGQKNHVM VYRLLSKDTI EEDVLERARR KMILEYAIIS LGVTDKQKNS
860 870 880 890 900
KNDKFSAEEL SAILKFGASN MFKAENNQKK LEDMNLDEIL EHAEDHDTSN
910 920 930 940 950
DVGGASMGGE EFLKQFEVTD YKADVSWDDI IPLTEREKFE EEDRLREEEE
960 970 980 990 1000
ALKQEIELSS RRGNRPYPSS AVESPSYSGT SERKSKKQML KDEVLLEKEI
1010 1020 1030 1040 1050
RLLYRAMIRY GSLEHRYNDI VKYADLTTQD AHVIKKIAAD LVTASRKAVS
1060 1070 1080 1090 1100
AAEKDLSNDQ SNNKSSRKAL LITFKGVKNI NAETLVQRLN DLDILYDAMP
1110 1120 1130 1140 1150
TSGYSNFQIP MHVRSVHGWS CQWGPREDSM LLSGICKHGF GAWLEIRDDP
1160 1170 1180 1190 1200
ELKMKDKIFL EDTKQTDNSV PKDKENKEKK VPSAVHLVRR GEYLLSALRE
1210 1220 1230 1240 1250
HHQNFGIKSS PAISTNGKTQ PKKQTANRRQ SGKPNVKSAQ KIESATRTPS
1260 1270 1280 1290 1300
PAISESRKKP SSKDTKIETP SREQSRSQTA SPVKSEKDDG NVSLNAEQKA
1310 1320 1330 1340 1350
RCKELMYPVR KHMKRLRKDS SGLGRAELVK LLTECLTTIG KHIEKTVNDT
1360 1370 1380
PSEEKATVRK NLWMFACYFW PKEEVKYTSL ISMYEKMK
Length:1,388
Mass (Da):159,379
Last modified:January 1, 1998 - v1
Checksum:iF7B431084BD29F8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16277.1
PIRiT38720
RefSeqiNP_594967.1, NM_001020398.2

Genome annotation databases

EnsemblFungiiSPAC3G6.01.1; SPAC3G6.01.1:pep; SPAC3G6.01
KEGGispo:SPAC3G6.01

Similar proteinsi

Entry informationi

Entry nameiHRP3_SCHPO
AccessioniPrimary (citable) accession number: O14139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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