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Protein

Chromodomain helicase hrp3

Gene

hrp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in heterochromatin silencing. Required for transcriptional repression at the silence loci of mat3, where it has a direct role as a chromatin remodeling factor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi400 – 4078ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • chromatin silencing at silent mating-type cassette Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter Source: PomBase
  • regulation of nucleosome density Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain helicase hrp3 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase hrp3
Gene namesi
Name:hrp3
ORF Names:SPAC3G6.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3G6.01.
PomBaseiSPAC3G6.01. hrp3.

Subcellular locationi

GO - Cellular componenti

  • mating-type region heterochromatin Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13881388Chromodomain helicase hrp3PRO_0000080242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1250 – 12501Phosphoserine1 Publication
Modified residuei1285 – 12851Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14139.

PTM databases

iPTMnetiO14139.
SwissPalmiO14139.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
swi6P403812EBI-7414157,EBI-926939

Protein-protein interaction databases

BioGridi279497. 290 interactions.
IntActiO14139. 3 interactions.
MINTiMINT-4670837.

Structurei

3D structure databases

ProteinModelPortaliO14139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 26070Chromo 1PROSITE-ProRule annotationAdd
BLAST
Domaini288 – 34962Chromo 2PROSITE-ProRule annotationAdd
BLAST
Domaini387 – 557171Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini694 – 852159Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi508 – 5114DEAH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi169 – 1757Poly-Glu
Compositional biasi947 – 9504Poly-Glu

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 2 chromo domains.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000207917.
InParanoidiO14139.
KOiK11367.
OMAiEIISHAN.
OrthoDBiEOG7M98QM.
PhylomeDBiO14139.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR025260. DUF4208.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00385. Chromo. 2 hits.
PF13907. DUF4208. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM01176. DUF4208. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSAIALAL SSSKAIEQLD HVQTETPNLK QEMSESPSNS GVASKRKLQS
60 70 80 90 100
TEWLDPELYG LRRSGRTRSN PGRYVDTDDQ EDVFPSKHRK GTRNGSSFSR
110 120 130 140 150
HRTIRDLDDE AESVTSEESE SDDSSYGGTP KKRSRQKKSN TYVQDEIRFS
160 170 180 190 200
SRNSKGVNYN EDAYFESFEE EEEEEMYEYA TEVSEEPEDT RAIDVVLDHR
210 220 230 240 250
LIEGHDGSTP SEDYEFLIKW VNFSHLHCTW EPYNNISMIR GSKKVDNHIK
260 270 280 290 300
QVILLDREIR EDPTTTREDI EAMDIEKERK RENYEEYKQV DRIVAKHLNS
310 320 330 340 350
DGSVEYLVKW KQLLYDFCTW EASSIIEPIA ATEIQAFQER EESALSPSRG
360 370 380 390 400
TNYGNSRPKY RKLEQQPSYI TGGELRDFQL TGVNWMAYLW HKNENGILAD
410 420 430 440 450
EMGLGKTVQT VAFLSYLAHS LRQHGPFLVV VPLSTVPAWQ ETLALWASDM
460 470 480 490 500
NCISYLGNTT SRQVIRDYEF YVDGTQKIKF NLLLTTYEYV LKDRSVLSNI
510 520 530 540 550
KWQYMAIDEA HRLKNSESSL YEALSQFKNS NRLLITGTPL QNNIRELAAL
560 570 580 590 600
VDFLMPGKFE IREEINLEAP DEEQEAYIRS LQEHLQPYIL RRLKKDVEKS
610 620 630 640 650
LPSKSERILR VELSDLQMYW YKNILTRNYR VLTQSISSGS QISLLNIVVE
660 670 680 690 700
LKKASNHPYL FDGVEESWMQ KINSQGRRDE VLKGLIMNSG KMVLLDKLLS
710 720 730 740 750
RLRRDGHRVL IFSQMVRMLD ILGDYLSLRG YPHQRLDGTV PAAVRRTSID
760 770 780 790 800
HFNAPNSPDF VFLLSTRAGG LGINLMTADT VIIFDSDWNP QADLQAMARA
810 820 830 840 850
HRIGQKNHVM VYRLLSKDTI EEDVLERARR KMILEYAIIS LGVTDKQKNS
860 870 880 890 900
KNDKFSAEEL SAILKFGASN MFKAENNQKK LEDMNLDEIL EHAEDHDTSN
910 920 930 940 950
DVGGASMGGE EFLKQFEVTD YKADVSWDDI IPLTEREKFE EEDRLREEEE
960 970 980 990 1000
ALKQEIELSS RRGNRPYPSS AVESPSYSGT SERKSKKQML KDEVLLEKEI
1010 1020 1030 1040 1050
RLLYRAMIRY GSLEHRYNDI VKYADLTTQD AHVIKKIAAD LVTASRKAVS
1060 1070 1080 1090 1100
AAEKDLSNDQ SNNKSSRKAL LITFKGVKNI NAETLVQRLN DLDILYDAMP
1110 1120 1130 1140 1150
TSGYSNFQIP MHVRSVHGWS CQWGPREDSM LLSGICKHGF GAWLEIRDDP
1160 1170 1180 1190 1200
ELKMKDKIFL EDTKQTDNSV PKDKENKEKK VPSAVHLVRR GEYLLSALRE
1210 1220 1230 1240 1250
HHQNFGIKSS PAISTNGKTQ PKKQTANRRQ SGKPNVKSAQ KIESATRTPS
1260 1270 1280 1290 1300
PAISESRKKP SSKDTKIETP SREQSRSQTA SPVKSEKDDG NVSLNAEQKA
1310 1320 1330 1340 1350
RCKELMYPVR KHMKRLRKDS SGLGRAELVK LLTECLTTIG KHIEKTVNDT
1360 1370 1380
PSEEKATVRK NLWMFACYFW PKEEVKYTSL ISMYEKMK
Length:1,388
Mass (Da):159,379
Last modified:January 1, 1998 - v1
Checksum:iF7B431084BD29F8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16277.1.
PIRiT38720.
RefSeqiNP_594967.1. NM_001020398.2.

Genome annotation databases

EnsemblFungiiSPAC3G6.01.1; SPAC3G6.01.1:pep; SPAC3G6.01.
GeneIDi2543064.
KEGGispo:SPAC3G6.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16277.1.
PIRiT38720.
RefSeqiNP_594967.1. NM_001020398.2.

3D structure databases

ProteinModelPortaliO14139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279497. 290 interactions.
IntActiO14139. 3 interactions.
MINTiMINT-4670837.

PTM databases

iPTMnetiO14139.
SwissPalmiO14139.

Proteomic databases

MaxQBiO14139.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC3G6.01.1; SPAC3G6.01.1:pep; SPAC3G6.01.
GeneIDi2543064.
KEGGispo:SPAC3G6.01.

Organism-specific databases

EuPathDBiFungiDB:SPAC3G6.01.
PomBaseiSPAC3G6.01. hrp3.

Phylogenomic databases

HOGENOMiHOG000207917.
InParanoidiO14139.
KOiK11367.
OMAiEIISHAN.
OrthoDBiEOG7M98QM.
PhylomeDBiO14139.

Miscellaneous databases

NextBioi20804092.
PROiO14139.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR025260. DUF4208.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00385. Chromo. 2 hits.
PF13907. DUF4208. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM01176. DUF4208. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 2 hits.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Hrp3, a chromodomain helicase/ATPase DNA binding protein, is required for heterochromatin silencing in fission yeast."
    Yoo E.J., Jang Y.K., Lee M.A., Bjerling P., Kim J.B., Ekwall K., Seong R.H., Park S.D.
    Biochem. Biophys. Res. Commun. 295:970-974(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME, FUNCTION, SUBCELLULAR LOCATION.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1250 AND SER-1285, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiHRP3_SCHPO
AccessioniPrimary (citable) accession number: O14139
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.