ID   G6PD3_SCHPO             Reviewed;         473 AA.
AC   O14137;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 54.
DE   RecName: Full=Probable glucose-6-phosphate 1-dehydrogenase C7.13c;
DE            Short=G6PD;
DE            EC=1.1.1.49;
GN   ORFNames=SPAC3C7.13c;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = D-glucono-
CC       1,5-lactone 6-phosphate + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family.
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DR   EMBL; CU329670; CAB16743.1; -; Genomic_DNA.
DR   PIR; T38699; T38699.
DR   RefSeq; NP_593614.1; -.
DR   HSSP; P11413; 1QKI.
DR   GeneID; 2543207; -.
DR   KEGG; spo:SPAC3C7.13c; -.
DR   NMPDR; fig|4896.1.peg.3584; -.
DR   GeneDB_Spombe; SPAC3C7.13c; -.
DR   ArrayExpress; O14137; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:EC.
DR   GO; GO:0033554; P:cellular response to stress; IEP:GeneDB_SPombe.
DR   GO; GO:0006010; P:glucose 6-phosphate utilization; IC:GeneDB_SPombe.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IC:GeneDB_SPombe.
DR   InterPro; IPR001282; Glc-6-P_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR23429; G6PDH; 1.
DR   Pfam; PF02781; G6PD_C; 1.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PIRSF; PIRSF000110; G6PD; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   ProDom; PD001129; G6PD; 1.
DR   TIGRFAMs; TIGR00871; zwf; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW   Glucose metabolism; NADP; Oxidoreductase.
FT   CHAIN         1    473       Probable glucose-6-phosphate 1-
FT                                dehydrogenase C7.13c.
FT                                /FTId=PRO_0000337688.
FT   ACT_SITE    237    237       Proton acceptor (By similarity).
FT   BINDING      10     10       NADP (By similarity).
FT   BINDING      43     43       NADP (By similarity).
FT   BINDING     174    174       Substrate (By similarity).
FT   BINDING     178    178       Substrate (By similarity).
SQ   SEQUENCE   473 AA;  54430 MW;  D932A886A65CE62F CRC64;
     MVTFMVFGAS GNLANKKTFP ALFHLFKRNL VDRSSFYVLG YARSKIPIGE FRESIRESVK
     PDTESKQVFQ DFIDRVSYFS GQYDQSSSYV EFRKHLESVE KKADSSKALR IFYIALPPSV
     YVTVSSHIYE NLYLPGKSRL VIEKPFGKNY QSAVKLKEEV HKHWKEEEIY RIDHYTAKDM
     VNNFFTLRFA NSSSIDAVLN RHSIQSVEIH MYETGGCEGR IGYYDANGVV RDVVQNHLTQ
     IFCIAAMNEP KSASASDVRA EKVNLLKATR PASLKESMLG QYTTSEDGKI PGYLDLEGVP
     KDSKATTFAA STLHVDNDRW KGVPFVFVSG KRMKKGEVYI KYYFRLKDSG IFSDVKRRRY
     LILHVQPEEF VNLTCTINKP MTTDLQPIDA YASLNYNEQF KDLMKEKRDG YEILFEDAIR
     GDPTKFIRYD EVEYAWKIWD EILDSPKKPI PYPAGSDGPE GLEAYMKRHL GHE
//