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O14137

- G6PD3_SCHPO

UniProt

O14137 - G6PD3_SCHPO

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Protein

Probable glucose-6-phosphate 1-dehydrogenase C7.13c

Gene

SPAC3C7.13c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431NADPBy similarity
Binding sitei144 – 1441NADP; via carbonyl oxygenBy similarity
Binding sitei144 – 1441SubstrateBy similarity
Binding sitei213 – 2131SubstrateBy similarity
Binding sitei232 – 2321SubstrateBy similarity
Active sitei237 – 2371Proton acceptorBy similarity
Binding sitei331 – 3311SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 158NADPBy similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: PomBase
  2. NADP binding Source: InterPro

GO - Biological processi

  1. glucose 6-phosphate metabolic process Source: PomBase
  2. pentose-phosphate shunt, oxidative branch Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose-6-phosphate 1-dehydrogenase C7.13c (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
ORF Names:SPAC3C7.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC3C7.13c.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Probable glucose-6-phosphate 1-dehydrogenase C7.13cPRO_0000337688Add
BLAST

Proteomic databases

MaxQBiO14137.

Interactioni

Protein-protein interaction databases

BioGridi279636. 1 interaction.
STRINGi4896.SPAC3C7.13c-1.

Structurei

3D structure databases

ProteinModelPortaliO14137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni174 – 1785Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046192.
InParanoidiO14137.
KOiK00036.
OMAiCEINDAV.
OrthoDBiEOG7TXKRP.
PhylomeDBiO14137.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.

Sequencei

Sequence statusi: Complete.

O14137-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTFMVFGAS GNLANKKTFP ALFHLFKRNL VDRSSFYVLG YARSKIPIGE
60 70 80 90 100
FRESIRESVK PDTESKQVFQ DFIDRVSYFS GQYDQSSSYV EFRKHLESVE
110 120 130 140 150
KKADSSKALR IFYIALPPSV YVTVSSHIYE NLYLPGKSRL VIEKPFGKNY
160 170 180 190 200
QSAVKLKEEV HKHWKEEEIY RIDHYTAKDM VNNFFTLRFA NSSSIDAVLN
210 220 230 240 250
RHSIQSVEIH MYETGGCEGR IGYYDANGVV RDVVQNHLTQ IFCIAAMNEP
260 270 280 290 300
KSASASDVRA EKVNLLKATR PASLKESMLG QYTTSEDGKI PGYLDLEGVP
310 320 330 340 350
KDSKATTFAA STLHVDNDRW KGVPFVFVSG KRMKKGEVYI KYYFRLKDSG
360 370 380 390 400
IFSDVKRRRY LILHVQPEEF VNLTCTINKP MTTDLQPIDA YASLNYNEQF
410 420 430 440 450
KDLMKEKRDG YEILFEDAIR GDPTKFIRYD EVEYAWKIWD EILDSPKKPI
460 470
PYPAGSDGPE GLEAYMKRHL GHE
Length:473
Mass (Da):54,430
Last modified:January 1, 1998 - v1
Checksum:iD932A886A65CE62F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16743.1.
PIRiT38699.
RefSeqiNP_593614.1. NM_001019045.2.

Genome annotation databases

EnsemblFungiiSPAC3C7.13c.1; SPAC3C7.13c.1:pep; SPAC3C7.13c.
GeneIDi2543207.
KEGGispo:SPAC3C7.13c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16743.1 .
PIRi T38699.
RefSeqi NP_593614.1. NM_001019045.2.

3D structure databases

ProteinModelPortali O14137.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279636. 1 interaction.
STRINGi 4896.SPAC3C7.13c-1.

Proteomic databases

MaxQBi O14137.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC3C7.13c.1 ; SPAC3C7.13c.1:pep ; SPAC3C7.13c .
GeneIDi 2543207.
KEGGi spo:SPAC3C7.13c.

Organism-specific databases

PomBasei SPAC3C7.13c.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046192.
InParanoidi O14137.
KOi K00036.
OMAi CEINDAV.
OrthoDBi EOG7TXKRP.
PhylomeDBi O14137.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Miscellaneous databases

NextBioi 20804230.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiG6PD3_SCHPO
AccessioniPrimary (citable) accession number: O14137
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3