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O14137

- G6PD3_SCHPO

UniProt

O14137 - G6PD3_SCHPO

Protein

Probable glucose-6-phosphate 1-dehydrogenase C7.13c

Gene

SPAC3C7.13c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431NADPBy similarity
    Binding sitei144 – 1441NADP; via carbonyl oxygenBy similarity
    Binding sitei144 – 1441SubstrateBy similarity
    Binding sitei213 – 2131SubstrateBy similarity
    Binding sitei232 – 2321SubstrateBy similarity
    Active sitei237 – 2371Proton acceptorBy similarity
    Binding sitei331 – 3311SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 158NADPBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: PomBase
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. glucose 6-phosphate metabolic process Source: PomBase
    2. pentose-phosphate shunt, oxidative branch Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glucose-6-phosphate 1-dehydrogenase C7.13c (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    ORF Names:SPAC3C7.13c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC3C7.13c.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473Probable glucose-6-phosphate 1-dehydrogenase C7.13cPRO_0000337688Add
    BLAST

    Proteomic databases

    MaxQBiO14137.

    Interactioni

    Protein-protein interaction databases

    BioGridi279636. 1 interaction.
    STRINGi4896.SPAC3C7.13c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO14137.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni174 – 1785Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046192.
    KOiK00036.
    OMAiCEINDAV.
    OrthoDBiEOG7TXKRP.
    PhylomeDBiO14137.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O14137-1 [UniParc]FASTAAdd to Basket

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    MVTFMVFGAS GNLANKKTFP ALFHLFKRNL VDRSSFYVLG YARSKIPIGE    50
    FRESIRESVK PDTESKQVFQ DFIDRVSYFS GQYDQSSSYV EFRKHLESVE 100
    KKADSSKALR IFYIALPPSV YVTVSSHIYE NLYLPGKSRL VIEKPFGKNY 150
    QSAVKLKEEV HKHWKEEEIY RIDHYTAKDM VNNFFTLRFA NSSSIDAVLN 200
    RHSIQSVEIH MYETGGCEGR IGYYDANGVV RDVVQNHLTQ IFCIAAMNEP 250
    KSASASDVRA EKVNLLKATR PASLKESMLG QYTTSEDGKI PGYLDLEGVP 300
    KDSKATTFAA STLHVDNDRW KGVPFVFVSG KRMKKGEVYI KYYFRLKDSG 350
    IFSDVKRRRY LILHVQPEEF VNLTCTINKP MTTDLQPIDA YASLNYNEQF 400
    KDLMKEKRDG YEILFEDAIR GDPTKFIRYD EVEYAWKIWD EILDSPKKPI 450
    PYPAGSDGPE GLEAYMKRHL GHE 473
    Length:473
    Mass (Da):54,430
    Last modified:January 1, 1998 - v1
    Checksum:iD932A886A65CE62F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16743.1.
    PIRiT38699.
    RefSeqiNP_593614.1. NM_001019045.2.

    Genome annotation databases

    EnsemblFungiiSPAC3C7.13c.1; SPAC3C7.13c.1:pep; SPAC3C7.13c.
    GeneIDi2543207.
    KEGGispo:SPAC3C7.13c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16743.1 .
    PIRi T38699.
    RefSeqi NP_593614.1. NM_001019045.2.

    3D structure databases

    ProteinModelPortali O14137.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279636. 1 interaction.
    STRINGi 4896.SPAC3C7.13c-1.

    Proteomic databases

    MaxQBi O14137.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC3C7.13c.1 ; SPAC3C7.13c.1:pep ; SPAC3C7.13c .
    GeneIDi 2543207.
    KEGGi spo:SPAC3C7.13c.

    Organism-specific databases

    PomBasei SPAC3C7.13c.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046192.
    KOi K00036.
    OMAi CEINDAV.
    OrthoDBi EOG7TXKRP.
    PhylomeDBi O14137.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Miscellaneous databases

    NextBioi 20804230.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiG6PD3_SCHPO
    AccessioniPrimary (citable) accession number: O14137
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3