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O14137 (G6PD3_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glucose-6-phosphate 1-dehydrogenase C7.13c

Short name=G6PD
EC=1.1.1.49
Gene names
ORF Names:SPAC3C7.13c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00966.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 473473Probable glucose-6-phosphate 1-dehydrogenase C7.13c HAMAP-Rule MF_00966
PRO_0000337688

Regions

Nucleotide binding8 – 158NADP By similarity
Region174 – 1785Substrate binding By similarity

Sites

Active site2371Proton acceptor By similarity
Binding site431NADP By similarity
Binding site1441NADP; via carbonyl oxygen By similarity
Binding site1441Substrate By similarity
Binding site2131Substrate By similarity
Binding site2321Substrate By similarity
Binding site3311Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O14137 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: D932A886A65CE62F

FASTA47354,430
        10         20         30         40         50         60 
MVTFMVFGAS GNLANKKTFP ALFHLFKRNL VDRSSFYVLG YARSKIPIGE FRESIRESVK 

        70         80         90        100        110        120 
PDTESKQVFQ DFIDRVSYFS GQYDQSSSYV EFRKHLESVE KKADSSKALR IFYIALPPSV 

       130        140        150        160        170        180 
YVTVSSHIYE NLYLPGKSRL VIEKPFGKNY QSAVKLKEEV HKHWKEEEIY RIDHYTAKDM 

       190        200        210        220        230        240 
VNNFFTLRFA NSSSIDAVLN RHSIQSVEIH MYETGGCEGR IGYYDANGVV RDVVQNHLTQ 

       250        260        270        280        290        300 
IFCIAAMNEP KSASASDVRA EKVNLLKATR PASLKESMLG QYTTSEDGKI PGYLDLEGVP 

       310        320        330        340        350        360 
KDSKATTFAA STLHVDNDRW KGVPFVFVSG KRMKKGEVYI KYYFRLKDSG IFSDVKRRRY 

       370        380        390        400        410        420 
LILHVQPEEF VNLTCTINKP MTTDLQPIDA YASLNYNEQF KDLMKEKRDG YEILFEDAIR 

       430        440        450        460        470 
GDPTKFIRYD EVEYAWKIWD EILDSPKKPI PYPAGSDGPE GLEAYMKRHL GHE 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAB16743.1.
PIRT38699.
RefSeqNP_593614.1. NM_001019045.2.

3D structure databases

ProteinModelPortalO14137.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279636. 1 interaction.
STRING4896.SPAC3C7.13c-1.

Proteomic databases

MaxQBO14137.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC3C7.13c.1; SPAC3C7.13c.1:pep; SPAC3C7.13c.
GeneID2543207.
KEGGspo:SPAC3C7.13c.

Organism-specific databases

PomBaseSPAC3C7.13c.

Phylogenomic databases

eggNOGCOG0364.
HOGENOMHOG000046192.
KOK00036.
OMACEINDAV.
OrthoDBEOG7TXKRP.
PhylomeDBO14137.

Enzyme and pathway databases

UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
ProtoNetSearch...

Other

NextBio20804230.

Entry information

Entry nameG6PD3_SCHPO
AccessionPrimary (citable) accession number: O14137
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways