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Protein

mRNA export factor elf1

Gene

elf1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a direct role in the mRNA export process. Appears to act within the rae1 mediated mRNA export pathway.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi477 – 484ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi726 – 733ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: PomBase
  • ATP binding Source: PomBase

GO - Biological processi

  • mRNA export from nucleus Source: PomBase
  • poly(A)+ mRNA export from nucleus Source: PomBase
  • ribosomal small subunit biogenesis Source: PomBase

Keywordsi

Biological processmRNA transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA export factor elf1
Gene namesi
Name:elf1
ORF Names:SPAC3C7.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3C7.08c
PomBaseiSPAC3C7.08c elf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi731G → D: No mRNA transport. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000934601 – 1057mRNA export factor elf1Add BLAST1057

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei733Phosphoserine1 Publication1
Modified residuei1041Phosphoserine1 Publication1
Modified residuei1053Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14134
PaxDbiO14134
PRIDEiO14134

PTM databases

iPTMnetiO14134

Interactioni

Protein-protein interaction databases

BioGridi279515, 10 interactors
STRINGi4896.SPAC3C7.08c.1

Structurei

3D structure databases

ProteinModelPortaliO14134
SMRiO14134
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini440 – 659ABC transporter 1PROSITE-ProRule annotationAdd BLAST220
Domaini692 – 1019ABC transporter 2PROSITE-ProRule annotationAdd BLAST328
Domaini820 – 869ChromoPROSITE-ProRule annotationAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi329 – 338Poly-Ala10

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000180957
InParanoidiO14134
KOiK03235
OMAiPKGTPHP
OrthoDBiEOG092C22OB
PhylomeDBiO14134

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000953 Chromo/chromo_shadow_dom
IPR023780 Chromo_domain
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
PF00385 Chromo, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SM00298 CHROMO, 1 hit
SUPFAMiSSF48371 SSF48371, 6 hits
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits
PS50013 CHROMO_2, 1 hit

Sequencei

Sequence statusi: Complete.

O14134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSVLIQGY EEDDVLKLLQ ELLDAETSQS CADVGKKIAQ LFSNDNPLVT
60 70 80 90 100
LKTTGFLDGL ERAARNKKSG FHREAAMIGF ATVIKNLGTP SEVVFLPYLP
110 120 130 140 150
TILDSFSDRG EVVRQAAKMA AQALLDCLPA GAVETRLIPS LISYLDDSSI
160 170 180 190 200
KWPSKVAALQ LLGSLASSSP KAVADYMAAL IPCIKERMHD TKPEISRAAI
210 220 230 240 250
TCMLNLCSVV ENNDIIPHIP KLVDCMAHPE TLEACIKDLS ATTFVATVES
260 270 280 290 300
VALAVLVPIL KRALAQRSQS MLRLTVIITD NLCKLVPDPA EASDFLPELI
310 320 330 340 350
PDVERIAQTA AMPEVRALAS HALTTLNKAA AAQAAKAANN SEKQALDSAC
360 370 380 390 400
KELREAVLKN TSVPHELANS IIDYVCDALA ALYKSNNFDK DKWTSQLGVL
410 420 430 440 450
YLSPLVGEEL ASQISSKIYD DLHAFYKSLN SVDGISNLTI EEEELVNTDF
460 470 480 490 500
SLAYGGRLLL SHTNLHLYRG HRYGVVGHNG CGKSTLLRAI GDYKVENFPS
510 520 530 540 550
PDEVKTCFVA HSLQGEDTSM AILDFVAQDK ALLTMNVTRQ EAADALHSVG
560 570 580 590 600
FTAEMQENPV ASLSGGWKMK LELARAMLQK ADILLLDEPT NHLDVANIAW
610 620 630 640 650
LEAYLTSQKN ITCLIVSHDS SFLDHVCTDI IHYEGVKNQA KKLGYYQGNL
660 670 680 690 700
SAFVKVKPEA KSYYTLTATN EKFVFPPPGI LTGVRSNTRL ILKMTNASYT
710 720 730 740 750
YPNAKKKSLD NVTVGLSLSS RVAILGPNGA GKSTLIKVLI GEVIPQEGKV
760 770 780 790 800
FKHPNLRVGY VAQHAFHHLD QHLEKTPSQY IQWRYAGGQD REVSEKESRK
810 820 830 840 850
LTEEDRAQLQ RDITVNGERR RVEALIGRQK LKKSFQYEIK WFGKPHKYNT
860 870 880 890 900
WVSREILLEN GFQKFVQAFD DMESSREGLG FRELIPEDIR AHFEDVGLPG
910 920 930 940 950
DIADYSPISS LSGGQKVKVV IAACLWNNPQ LLVLDEPTNF LDRDALGGLA
960 970 980 990 1000
VAIRDWEGGV VMISHNEEFV SALCPEHWHV EAGKVTGKGK TAVDDGKFED
1010 1020 1030 1040 1050
LSEKDLKKIE AKATKKKKLT RNEIKAKERR ARERELAWLQ SPKGTEKPKS

FFSDDEE
Length:1,057
Mass (Da):116,701
Last modified:January 1, 1998 - v1
Checksum:i60DF5AE9DFC9D9F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16738.1
PIRiT38694
RefSeqiNP_593609.1, NM_001019040.2

Genome annotation databases

EnsemblFungiiSPAC3C7.08c.1; SPAC3C7.08c.1:pep; SPAC3C7.08c
GeneIDi2543082
KEGGispo:SPAC3C7.08c

Entry informationi

Entry nameiELF1_SCHPO
AccessioniPrimary (citable) accession number: O14134
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health