Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

26S proteasome regulatory subunit 6A

Gene

tbp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi226 – 233ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-6798695. Neutrophil degranulation.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit 6A
Gene namesi
Name:tbp1
Synonyms:pam2
ORF Names:SPAC3A11.12c, SPAC3H5.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3A11.12c.
PomBaseiSPAC3A11.12c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847071 – 43826S proteasome regulatory subunit 6AAdd BLAST438

Proteomic databases

MaxQBiO14126.
PRIDEiO14126.

PTM databases

iPTMnetiO14126.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi280538. 15 interactors.
MINTiMINT-4670701.
STRINGi4896.SPAC3A11.12c.1.

Structurei

3D structure databases

ProteinModelPortaliO14126.
SMRiO14126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

HOGENOMiHOG000225143.
InParanoidiO14126.
KOiK03065.
OMAiRACAAQS.
OrthoDBiEOG092C19WS.
PhylomeDBiO14126.

Family and domain databases

InterProiView protein in InterPro
IPR005937. 26S_Psome_P45-like.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR035254. PSMC3.
PANTHERiPTHR23073:SF7. PTHR23073:SF7. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

O14126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLEELDAL DQSQQGGSSN NEGLDGIEQE ILAAGIDELN SRTRLLENDI
60 70 80 90 100
KVMKSEFQRL THEKSTMLEK IKENQEKISN NKMLPYLVGN VVEILDMQPD
110 120 130 140 150
EVDVQESANQ NSEATRVGKS AVIKTSTRQT IFLPLIGLVE PEELHPGDLI
160 170 180 190 200
GVNKDSYLII DKLPSEYDSR VKAMEVDEKP TERYSDIGGL SKQIEELFEA
210 220 230 240 250
IVLPMQQADK FRKLGVKPPK GCLMFGPPGT GKTLLARACA AQSNATFLKL
260 270 280 290 300
AAPQLVQMFI GDGAKLVRDA FALAKEKSPA IIFIDELDAI GTKRFDSEKA
310 320 330 340 350
GDREVQRTML ELLNQLDGFS SDDRVKVIAA TNRVDTLDPA LLRSGRLDRK
360 370 380 390 400
LEFPLPNEEA RVGILRIHSR KMAIDDDINW EELARSTDEY NGAMLKSVCV
410 420 430
EAGMIALRQG DTKINHEHFM DGILEVQMRK SKTLQYFA
Length:438
Mass (Da):48,836
Last modified:January 1, 1998 - v1
Checksum:iB3C7863519FB7676
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012136 Genomic DNA. Translation: BAA88693.1.
CU329670 Genomic DNA. Translation: CAB16588.1.
PIRiT11634.
RefSeqiXP_001713083.1. XM_001713031.2.

Genome annotation databases

EnsemblFungiiSPAC3A11.12c.1; SPAC3A11.12c.1:pep; SPAC3A11.12c.
GeneIDi3361462.
KEGGispo:SPAC3A11.12c.

Similar proteinsi

Entry informationi

Entry nameiPRS6A_SCHPO
AccessioniPrimary (citable) accession number: O14126
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families