Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

26S protease regulatory subunit 6A

Gene

tbp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi226 – 2338ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S protease regulatory subunit 6A
Gene namesi
Name:tbp1
Synonyms:pam2
ORF Names:SPAC3A11.12c, SPAC3H5.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3A11.12c.
PomBaseiSPAC3A11.12c.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: UniProtKB-SubCell
  • proteasome regulatory particle, base subcomplex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 43843826S protease regulatory subunit 6APRO_0000084707Add
BLAST

Proteomic databases

MaxQBiO14126.
PRIDEiO14126.

Interactioni

Protein-protein interaction databases

BioGridi280538. 14 interactions.
MINTiMINT-4670701.

Structurei

3D structure databases

ProteinModelPortaliO14126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

HOGENOMiHOG000225143.
InParanoidiO14126.
KOiK03065.
OMAiRISHAID.
OrthoDBiEOG7X3R1G.
PhylomeDBiO14126.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLEELDAL DQSQQGGSSN NEGLDGIEQE ILAAGIDELN SRTRLLENDI
60 70 80 90 100
KVMKSEFQRL THEKSTMLEK IKENQEKISN NKMLPYLVGN VVEILDMQPD
110 120 130 140 150
EVDVQESANQ NSEATRVGKS AVIKTSTRQT IFLPLIGLVE PEELHPGDLI
160 170 180 190 200
GVNKDSYLII DKLPSEYDSR VKAMEVDEKP TERYSDIGGL SKQIEELFEA
210 220 230 240 250
IVLPMQQADK FRKLGVKPPK GCLMFGPPGT GKTLLARACA AQSNATFLKL
260 270 280 290 300
AAPQLVQMFI GDGAKLVRDA FALAKEKSPA IIFIDELDAI GTKRFDSEKA
310 320 330 340 350
GDREVQRTML ELLNQLDGFS SDDRVKVIAA TNRVDTLDPA LLRSGRLDRK
360 370 380 390 400
LEFPLPNEEA RVGILRIHSR KMAIDDDINW EELARSTDEY NGAMLKSVCV
410 420 430
EAGMIALRQG DTKINHEHFM DGILEVQMRK SKTLQYFA
Length:438
Mass (Da):48,836
Last modified:January 1, 1998 - v1
Checksum:iB3C7863519FB7676
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012136 Genomic DNA. Translation: BAA88693.1.
CU329670 Genomic DNA. Translation: CAB16588.1.
PIRiT11634.
RefSeqiXP_001713083.1. XM_001713031.2.

Genome annotation databases

EnsemblFungiiSPAC3A11.12c.1; SPAC3A11.12c.1:pep; SPAC3A11.12c.
GeneIDi3361462.
KEGGispo:SPAC3A11.12c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012136 Genomic DNA. Translation: BAA88693.1.
CU329670 Genomic DNA. Translation: CAB16588.1.
PIRiT11634.
RefSeqiXP_001713083.1. XM_001713031.2.

3D structure databases

ProteinModelPortaliO14126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi280538. 14 interactions.
MINTiMINT-4670701.

Proteomic databases

MaxQBiO14126.
PRIDEiO14126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC3A11.12c.1; SPAC3A11.12c.1:pep; SPAC3A11.12c.
GeneIDi3361462.
KEGGispo:SPAC3A11.12c.

Organism-specific databases

EuPathDBiFungiDB:SPAC3A11.12c.
PomBaseiSPAC3A11.12c.

Phylogenomic databases

HOGENOMiHOG000225143.
InParanoidiO14126.
KOiK03065.
OMAiRISHAID.
OrthoDBiEOG7X3R1G.
PhylomeDBiO14126.

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

NextBioi20811506.
PROiO14126.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Switch from mitotic to meiotic cell cycle is disturbed by strong activation of Ras-MAP kinase cascade in the fission yeast 26S proteasome-related mutants."
    Kitamura K., Tsujimoto K., Yamashita I., Shimoda C.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 38364 / 968.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPRS6A_SCHPO
AccessioniPrimary (citable) accession number: O14126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.