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Protein

Uncharacterized dipeptidase C3A11.10c

Gene

SPAC3A11.10c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi67 – 671Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi69 – 691Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi181 – 1811Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi181 – 1811Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi250 – 2501Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi271 – 2711Zinc 2; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metallodipeptidase activity Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_273042. Synthesis of Leukotrienes (LT) and Eoxins (EX).
REACT_346894. Aflatoxin activation and detoxification.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized dipeptidase C3A11.10c (EC:3.4.13.19)
Gene namesi
ORF Names:SPAC3A11.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

PomBaseiSPAC3A11.10c.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 409370Uncharacterized dipeptidase C3A11.10cPRO_0000314654Add
BLAST

Proteomic databases

MaxQBiO14124.

Interactioni

Subunit structurei

Interacts with dil1.1 Publication

Protein-protein interaction databases

BioGridi279513. 25 interactions.
MINTiMINT-4670686.
STRINGi4896.SPAC3A11.10c-1.

Structurei

3D structure databases

ProteinModelPortaliO14124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2355.
HOGENOMiHOG000072016.
InParanoidiO14124.
KOiK01273.
OMAiPETFQCV.
OrthoDBiEOG7XM371.
PhylomeDBiO14124.

Family and domain databases

InterProiIPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSDSKLELP LPVNQQKPRR RRILKVHLLI AALILSAVGY LGKGKWIWTP
60 70 80 90 100
ERKAHFVLTH FPLIDGHNDL PIYLRENYDN RLLNISLEHL PGQTDIFRLR
110 120 130 140 150
QGHVGGQFWS VFVECPSLDS NSSLSWNRTG EYEAVTQTLQ QIDVVKRMAL
160 170 180 190 200
YYPKTFSLTD HSGKVKFDFL RNHISSMMGI EGLHQIAGSP SILRQFYDLG
210 220 230 240 250
VRYATLAHNC DNVFADAAVD GKRTNKGLSP AGRDIVREMN RLGMIVDLSH
260 270 280 290 300
TTPETMHQAL DVSVAPAFFS HSSAKGVYDH PRNVPDDVLI RVKETDGVVM
310 320 330 340 350
VNFYPAFISP HPENATIDTV VEHIMHIANV TGSYRHIGLG GDFDGIDMVP
360 370 380 390 400
KGLEDVSKYP DLFVKLAERG LSITELADIA GRNVLRVWKT TEDLGHSIHE

PPLEWEDDF
Length:409
Mass (Da):46,048
Last modified:December 31, 1997 - v1
Checksum:i860A95056C6B1CF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16385.1.
PIRiT11632.
RefSeqiNP_594193.1. NM_001019617.2.

Genome annotation databases

EnsemblFungiiSPAC3A11.10c.1; SPAC3A11.10c.1:pep; SPAC3A11.10c.
GeneIDi2543080.
KEGGispo:SPAC3A11.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16385.1.
PIRiT11632.
RefSeqiNP_594193.1. NM_001019617.2.

3D structure databases

ProteinModelPortaliO14124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279513. 25 interactions.
MINTiMINT-4670686.
STRINGi4896.SPAC3A11.10c-1.

Proteomic databases

MaxQBiO14124.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC3A11.10c.1; SPAC3A11.10c.1:pep; SPAC3A11.10c.
GeneIDi2543080.
KEGGispo:SPAC3A11.10c.

Organism-specific databases

PomBaseiSPAC3A11.10c.

Phylogenomic databases

eggNOGiCOG2355.
HOGENOMiHOG000072016.
InParanoidiO14124.
KOiK01273.
OMAiPETFQCV.
OrthoDBiEOG7XM371.
PhylomeDBiO14124.

Enzyme and pathway databases

ReactomeiREACT_273042. Synthesis of Leukotrienes (LT) and Eoxins (EX).
REACT_346894. Aflatoxin activation and detoxification.

Miscellaneous databases

NextBioi20804108.

Family and domain databases

InterProiIPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I."
    Rumpf C., Cipak L., Novatchkova M., Li Z., Polakova S., Dudas A., Kovacikova I., Miadokova E., Ammerer G., Gregan J.
    Cell Cycle 9:1802-1808(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH DIL1.

Entry informationi

Entry nameiDPEH1_SCHPO
AccessioniPrimary (citable) accession number: O14124
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 14, 2008
Last sequence update: December 31, 1997
Last modified: March 31, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.