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O14124

- DPEH1_SCHPO

UniProt

O14124 - DPEH1_SCHPO

Protein

Uncharacterized dipeptidase C3A11.10c

Gene

SPAC3A11.10c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of dipeptides.PROSITE-ProRule annotation

    Cofactori

    Zinc.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi67 – 671Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi69 – 691Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi181 – 1811Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi181 – 1811Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi250 – 2501Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi271 – 2711Zinc 2; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. dipeptidase activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. metallopeptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Dipeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_193583. Synthesis of Leukotrienes (LT) and Eoxins (EX).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized dipeptidase C3A11.10c (EC:3.4.13.19)
    Gene namesi
    ORF Names:SPAC3A11.10c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC3A11.10c.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3939Sequence AnalysisAdd
    BLAST
    Chaini40 – 409370Uncharacterized dipeptidase C3A11.10cPRO_0000314654Add
    BLAST

    Proteomic databases

    MaxQBiO14124.

    Interactioni

    Subunit structurei

    Interacts with dil1.1 Publication

    Protein-protein interaction databases

    BioGridi279513. 25 interactions.
    MINTiMINT-4670686.
    STRINGi4896.SPAC3A11.10c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO14124.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M19 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2355.
    HOGENOMiHOG000072016.
    KOiK01273.
    OMAiLGAQFWV.
    OrthoDBiEOG7XM371.
    PhylomeDBiO14124.

    Family and domain databases

    InterProiIPR008257. Renal_dipep_fam.
    [Graphical view]
    PANTHERiPTHR10443. PTHR10443. 1 hit.
    PfamiPF01244. Peptidase_M19. 1 hit.
    [Graphical view]
    PROSITEiPS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14124-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSDSKLELP LPVNQQKPRR RRILKVHLLI AALILSAVGY LGKGKWIWTP    50
    ERKAHFVLTH FPLIDGHNDL PIYLRENYDN RLLNISLEHL PGQTDIFRLR 100
    QGHVGGQFWS VFVECPSLDS NSSLSWNRTG EYEAVTQTLQ QIDVVKRMAL 150
    YYPKTFSLTD HSGKVKFDFL RNHISSMMGI EGLHQIAGSP SILRQFYDLG 200
    VRYATLAHNC DNVFADAAVD GKRTNKGLSP AGRDIVREMN RLGMIVDLSH 250
    TTPETMHQAL DVSVAPAFFS HSSAKGVYDH PRNVPDDVLI RVKETDGVVM 300
    VNFYPAFISP HPENATIDTV VEHIMHIANV TGSYRHIGLG GDFDGIDMVP 350
    KGLEDVSKYP DLFVKLAERG LSITELADIA GRNVLRVWKT TEDLGHSIHE 400
    PPLEWEDDF 409
    Length:409
    Mass (Da):46,048
    Last modified:January 1, 1998 - v1
    Checksum:i860A95056C6B1CF1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16385.1.
    PIRiT11632.
    RefSeqiNP_594193.1. NM_001019617.2.

    Genome annotation databases

    EnsemblFungiiSPAC3A11.10c.1; SPAC3A11.10c.1:pep; SPAC3A11.10c.
    GeneIDi2543080.
    KEGGispo:SPAC3A11.10c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16385.1 .
    PIRi T11632.
    RefSeqi NP_594193.1. NM_001019617.2.

    3D structure databases

    ProteinModelPortali O14124.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279513. 25 interactions.
    MINTi MINT-4670686.
    STRINGi 4896.SPAC3A11.10c-1.

    Proteomic databases

    MaxQBi O14124.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC3A11.10c.1 ; SPAC3A11.10c.1:pep ; SPAC3A11.10c .
    GeneIDi 2543080.
    KEGGi spo:SPAC3A11.10c.

    Organism-specific databases

    PomBasei SPAC3A11.10c.

    Phylogenomic databases

    eggNOGi COG2355.
    HOGENOMi HOG000072016.
    KOi K01273.
    OMAi LGAQFWV.
    OrthoDBi EOG7XM371.
    PhylomeDBi O14124.

    Enzyme and pathway databases

    Reactomei REACT_193583. Synthesis of Leukotrienes (LT) and Eoxins (EX).

    Miscellaneous databases

    NextBioi 20804108.

    Family and domain databases

    InterProi IPR008257. Renal_dipep_fam.
    [Graphical view ]
    PANTHERi PTHR10443. PTHR10443. 1 hit.
    Pfami PF01244. Peptidase_M19. 1 hit.
    [Graphical view ]
    PROSITEi PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I."
      Rumpf C., Cipak L., Novatchkova M., Li Z., Polakova S., Dudas A., Kovacikova I., Miadokova E., Ammerer G., Gregan J.
      Cell Cycle 9:1802-1808(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH DIL1.

    Entry informationi

    Entry nameiDPEH1_SCHPO
    AccessioniPrimary (citable) accession number: O14124
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3