ID   NDH1_SCHPO              Reviewed;         551 AA.
AC   O14121;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   07-JUL-2009, entry version 54.
DE   RecName: Full=Probable NADH-ubiquinone oxidoreductase C3A11.07, mitochondrial;
DE            EC=1.6.5.3;
DE   Flags: Precursor;
GN   ORFNames=SPAC3A11.07;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the
RT   fission yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Catalyzes the oxidation of NADH (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the NADH dehydrogenase family.
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DR   EMBL; CU329670; CAB16382.1; -; Genomic_DNA.
DR   PIR; T11629; T11629.
DR   RefSeq; NP_594196.1; -.
DR   GeneID; 2543119; -.
DR   KEGG; spo:SPAC3A11.07; -.
DR   NMPDR; fig|4896.1.peg.4166; -.
DR   GeneDB_Spombe; SPAC3A11.07; -.
DR   OMA; O14121; LEDMARY.
DR   ArrayExpress; O14121; -.
DR   GO; GO:0005739; C:mitochondrion; IDA:GeneDB_SPombe.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013027; FAD_pyr_nucl-diS_OxRdtase.
DR   InterPro; IPR001327; Pyr_OxRdtase_NAD_bd.
DR   Pfam; PF00070; Pyr_redox; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; FAD; Flavoprotein; Mitochondrion; NAD;
KW   Oxidoreductase; Transit peptide; Ubiquinone.
FT   TRANSIT       1     37       Mitochondrion (Potential).
FT   CHAIN        38    551       Probable NADH-ubiquinone oxidoreductase
FT                                C3A11.07, mitochondrial.
FT                                /FTId=PRO_0000337257.
FT   NP_BIND      93    123       FAD (By similarity).
FT   NP_BIND     255    291       NAD (By similarity).
SQ   SEQUENCE   551 AA;  61675 MW;  FED02DB71DEB9281 CRC64;
     MLFSRSILRG MPKAGIPKSP LALSASRNLR LANSVRFASD AASSPKSTTS KWKILKRTTL
     GLFATAVVLY GANVYRFRHP DPHQPLPDPS KKTLVVLGAG WGATSILRTI DTSLFNVIVV
     SPRNYFLFTS LLPSTATGSV HTRSIVQPIR YMLRHKSCYV KFYEAECTDV DADKKVIHIK
     KTTTDGVDLE QEIKYDYLVC SHGAETQTFN IPGIAEYGCF LKEIWDAQKI RARILHCLEQ
     AQFKDLPAET RRRYVHTVVV GGGPTGMEFA GEMADFIEDD LKSWYPELAD DFAVTLVEAL
     PSVLPMFSAK LRDYTQSLFD SSHIKIRTNT ALKKVTAENI HVEVKNPDGS KQEEVIPYGL
     LVWAGGNRAR PLTKKLMEGS EEQNNRRGLV VDEYLKLKGY KDIFALGDCT HTAYAPTAQV
     ASQQGAYLGQ LFNKLGSLNF EKPSEDRHIA LGDEMDSSTL ISLANEKHAS TKVFLPFKYS
     HQGSLAYVGH EKAIADIEVP WFGKQLHASG ALAFYFWRSV YLSELYSLRN RTNVTLDWIR
     VKLFGRDISS L
//