Reviewed, UniProtKB/Swiss-Prot O14121 (NDH1_SCHPO)

Names and origin

Protein names

Recommended name:
    Probable NADH-ubiquinone oxidoreductase C3A11.07, mitochondrial
    EC=1.6.5.3

Gene names

ORF Names:

SPAC3A11.07

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the oxidation of NADH By similarity.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol.
Subcellular location	Mitochondrion. Ref.2
Sequence similarities	Belongs to the NADH dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein NAD Ubiquinone
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Ref.2 Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 37	37	Mitochondrion Potential
	Chain	38 – 551	514	Probable NADH-ubiquinone oxidoreductase C3A11.07, mitochondrial		PRO_0000337257
Regions
	Nucleotide binding	93 – 123	31	FAD By similarity
	Nucleotide binding	255 – 291	37	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	O14121-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: FED02DB71DEB9281	FASTA	551	61,675
	10 20 30 40 50 60 MLFSRSILRG MPKAGIPKSP LALSASRNLR LANSVRFASD AASSPKSTTS KWKILKRTTL 70 80 90 100 110 120 GLFATAVVLY GANVYRFRHP DPHQPLPDPS KKTLVVLGAG WGATSILRTI DTSLFNVIVV 130 140 150 160 170 180 SPRNYFLFTS LLPSTATGSV HTRSIVQPIR YMLRHKSCYV KFYEAECTDV DADKKVIHIK 190 200 210 220 230 240 KTTTDGVDLE QEIKYDYLVC SHGAETQTFN IPGIAEYGCF LKEIWDAQKI RARILHCLEQ 250 260 270 280 290 300 AQFKDLPAET RRRYVHTVVV GGGPTGMEFA GEMADFIEDD LKSWYPELAD DFAVTLVEAL 310 320 330 340 350 360 PSVLPMFSAK LRDYTQSLFD SSHIKIRTNT ALKKVTAENI HVEVKNPDGS KQEEVIPYGL 370 380 390 400 410 420 LVWAGGNRAR PLTKKLMEGS EEQNNRRGLV VDEYLKLKGY KDIFALGDCT HTAYAPTAQV 430 440 450 460 470 480 ASQQGAYLGQ LFNKLGSLNF EKPSEDRHIA LGDEMDSSTL ISLANEKHAS TKVFLPFKYS 490 500 510 520 530 540 HQGSLAYVGH EKAIADIEVP WFGKQLHASG ALAFYFWRSV YLSELYSLRN RTNVTLDWIR 550 VKLFGRDISS L

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

[2]

"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU329670 Genomic DNA. Translation: CAB16382.1.
PIR	T11629.
RefSeq	NP_594196.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2543119.
KEGG	spo:SPAC3A11.07.
Organism-specific databases
GeneDB_Spombe	SPAC3A11.07.
Phylogenomic databases
OMA	O14121. LEDMARY.
Gene expression databases
ArrayExpress	O14121.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDH1_SCHPO

Accession

Primary (citable) accession number: O14121

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)