O14120 (MVP1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sorting nexin mvp1

Gene names

Name:	mvp1
ORF Names:	SPAC3A11.06

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	664 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for vacuolar protein sorting By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Domain	The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization By similarity.
Sequence similarities	Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Membrane
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell communication Inferred from electronic annotation. Source: InterPro cellular response to stress Inferred from expression pattern PubMed 12529438. Source: PomBase protein targeting to vacuole Inferred from sequence orthology. Source: PomBase
Cellular_component	Golgi apparatus Inferred from direct assay PubMed 16823372. Source: PomBase fungal-type vacuole membrane Inferred from direct assay PubMed 16823372. Source: PomBase
Molecular_function	phosphatidylinositol-3-phosphate binding Inferred from sequence orthology. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 664	664	Sorting nexin mvp1		PRO_0000238601
Regions
	Domain	279 – 395	117	PX
Sites
	Binding site	320	1	Phosphatidylinositol 3-phosphate By similarity
	Binding site	322	1	Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	346	1	Phosphatidylinositol 3-phosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O14120 [UniParc]. Last modified May 1, 2000. Version 3. Checksum: FB4E9F1C312FA85C	FASTA	664	76,861
	10 20 30 40 50 60 MGDNVFLEPD PWASSSNWGS PVKPLNYKTA IGNSSIPLQY RNYWDVFQAN NVLLFPEEES 70 80 90 100 110 120 YSDIFHVPQD VMKEFFTLIE SSSNQPLRQI QFFVLLALVA CYQLGVPSTL EQIFKQRNVL 130 140 150 160 170 180 PILQRFNPEL FNRSSDNETP LFPNNSPPAS TTALNLSSNI VPSINESKIL EQEDDDVSNK 190 200 210 220 230 240 SLPHAQQSII RSFPDIQKQP KGFFSYPSST VSSIAPSTLE AGNLHSQQPP KFSVDSSVDD 250 260 270 280 290 300 NAITPRKPFS KIPNRLSPST QPLLSNSRHS SFRLASSSTS FPASLEMNVD IDLEPSGYFF 310 320 330 340 350 360 YRHNNYIISD SSNTREVLRR YSDFFWLHSY LMKKYPFRRV PLIPLKKFHS KCFNSKQFFR 370 380 390 400 410 420 TPPPGLSDFV NDLSHHPIFS NDEVVRVFFT EPNVFKNWRR ENQKRIDQEI EQFLVVPQSQ 430 440 450 460 470 480 VPDASETVKE RLLKLNMSTT TAINNQLNIF RIFEKMIFTL QHFHEDFLRL QNSFNCLLDS 490 500 510 520 530 540 GLYHQVFTST FAQNESKIMS MASGHFYNID SLLHQQNDAV KHTFLLGLSK EIKILISLRL 550 560 570 580 590 600 LIERISEVFS TDLTKVRHTI SNDENLLRET ANSDESGRNR TFLNRSSKKR AENSLKSKKE 610 620 630 640 650 660 LYLKNLNQRY QIAHELEQEL SYLQDYVFSL GNPYVEYCKQ HVKLEEESLK IWHTLESDFS RLET

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329670 Genomic DNA. Translation: CAB16392.2.
PIR	T11628.
RefSeq	NP_594197.1. NM_001019621.2.
3D structure databases
ProteinModelPortal	O14120.
ModBase	Search...
Protein-protein interaction databases
STRING	4896.SPAC3A11.06-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC3A11.06.1; SPAC3A11.06.1:pep; SPAC3A11.06.
GeneID	2543124.
KEGG	spo:SPAC3A11.06.
Organism-specific databases
PomBase	SPAC3A11.06.
Phylogenomic databases
eggNOG	COG5391.
OrthoDB	EOG4W6S46.
Family and domain databases
Gene3D	3.30.1520.10. 1 hit.
InterPro	IPR001683. Phox. [Graphical view]
Pfam	PF00787. PX. 1 hit. [Graphical view]
SMART	SM00312. PX. 1 hit. [Graphical view]
SUPFAM	SSF64268. PX. 1 hit.
PROSITE	PS50195. PX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20804151.

Entry information

Entry name

MVP1_SCHPO

Accession

Primary (citable) accession number: O14120

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 69 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program