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Protein

Sorting nexin mvp1

Gene

mvp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for vacuolar protein sorting.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei320 – 3201Phosphatidylinositol 3-phosphateBy similarity
Binding sitei322 – 3221Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei346 – 3461Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  1. phosphatidylinositol-3-phosphate binding Source: PomBase
  2. phosphatidylinositol binding Source: GO_Central

GO - Biological processi

  1. autophagy Source: GO_Central
  2. CVT pathway Source: GO_Central
  3. endocytosis Source: GO_Central
  4. protein targeting to vacuole Source: PomBase
  5. vesicle organization Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin mvp1
Gene namesi
Name:mvp1
ORF Names:SPAC3A11.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3A11.06.
PomBaseiSPAC3A11.06.

Subcellular locationi

  1. Cytoplasm By similarity
  2. Membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. endosome Source: GO_Central
  2. extrinsic component of membrane Source: GO_Central
  3. fungal-type vacuole membrane Source: PomBase
  4. Golgi apparatus Source: PomBase
  5. pre-autophagosomal structure Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 664664Sorting nexin mvp1PRO_0000238601Add
BLAST

Proteomic databases

MaxQBiO14120.

Interactioni

Protein-protein interaction databases

BioGridi279556. 16 interactions.
MINTiMINT-4670637.
STRINGi4896.SPAC3A11.06-1.

Structurei

3D structure databases

ProteinModelPortaliO14120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini279 – 395117PXPROSITE-ProRule annotationAdd
BLAST

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5391.
InParanoidiO14120.
KOiK17922.
OrthoDBiEOG7B320H.
PhylomeDBiO14120.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDNVFLEPD PWASSSNWGS PVKPLNYKTA IGNSSIPLQY RNYWDVFQAN
60 70 80 90 100
NVLLFPEEES YSDIFHVPQD VMKEFFTLIE SSSNQPLRQI QFFVLLALVA
110 120 130 140 150
CYQLGVPSTL EQIFKQRNVL PILQRFNPEL FNRSSDNETP LFPNNSPPAS
160 170 180 190 200
TTALNLSSNI VPSINESKIL EQEDDDVSNK SLPHAQQSII RSFPDIQKQP
210 220 230 240 250
KGFFSYPSST VSSIAPSTLE AGNLHSQQPP KFSVDSSVDD NAITPRKPFS
260 270 280 290 300
KIPNRLSPST QPLLSNSRHS SFRLASSSTS FPASLEMNVD IDLEPSGYFF
310 320 330 340 350
YRHNNYIISD SSNTREVLRR YSDFFWLHSY LMKKYPFRRV PLIPLKKFHS
360 370 380 390 400
KCFNSKQFFR TPPPGLSDFV NDLSHHPIFS NDEVVRVFFT EPNVFKNWRR
410 420 430 440 450
ENQKRIDQEI EQFLVVPQSQ VPDASETVKE RLLKLNMSTT TAINNQLNIF
460 470 480 490 500
RIFEKMIFTL QHFHEDFLRL QNSFNCLLDS GLYHQVFTST FAQNESKIMS
510 520 530 540 550
MASGHFYNID SLLHQQNDAV KHTFLLGLSK EIKILISLRL LIERISEVFS
560 570 580 590 600
TDLTKVRHTI SNDENLLRET ANSDESGRNR TFLNRSSKKR AENSLKSKKE
610 620 630 640 650
LYLKNLNQRY QIAHELEQEL SYLQDYVFSL GNPYVEYCKQ HVKLEEESLK
660
IWHTLESDFS RLET
Length:664
Mass (Da):76,861
Last modified:May 1, 2000 - v3
Checksum:iFB4E9F1C312FA85C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16392.2.
PIRiT11628.
RefSeqiNP_594197.1. NM_001019621.2.

Genome annotation databases

EnsemblFungiiSPAC3A11.06.1; SPAC3A11.06.1:pep; SPAC3A11.06.
GeneIDi2543124.
KEGGispo:SPAC3A11.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16392.2.
PIRiT11628.
RefSeqiNP_594197.1. NM_001019621.2.

3D structure databases

ProteinModelPortaliO14120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279556. 16 interactions.
MINTiMINT-4670637.
STRINGi4896.SPAC3A11.06-1.

Proteomic databases

MaxQBiO14120.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC3A11.06.1; SPAC3A11.06.1:pep; SPAC3A11.06.
GeneIDi2543124.
KEGGispo:SPAC3A11.06.

Organism-specific databases

EuPathDBiFungiDB:SPAC3A11.06.
PomBaseiSPAC3A11.06.

Phylogenomic databases

eggNOGiCOG5391.
InParanoidiO14120.
KOiK17922.
OrthoDBiEOG7B320H.
PhylomeDBiO14120.

Miscellaneous databases

NextBioi20804151.
PROiO14120.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiMVP1_SCHPO
AccessioniPrimary (citable) accession number: O14120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 1, 2000
Last modified: April 29, 2015
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.