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O14120 (MVP1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sorting nexin mvp1
Gene names
Name:mvp1
ORF Names:SPAC3A11.06
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length664 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for vacuolar protein sorting By similarity.

Subcellular location

Cytoplasm By similarity. Membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Domain

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization By similarity.

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 PX (phox homology) domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 664664Sorting nexin mvp1
PRO_0000238601

Regions

Domain279 – 395117PX

Sites

Binding site3201Phosphatidylinositol 3-phosphate By similarity
Binding site3221Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding site3461Phosphatidylinositol 3-phosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
O14120 [UniParc].

Last modified May 1, 2000. Version 3.
Checksum: FB4E9F1C312FA85C

FASTA66476,861
        10         20         30         40         50         60 
MGDNVFLEPD PWASSSNWGS PVKPLNYKTA IGNSSIPLQY RNYWDVFQAN NVLLFPEEES 

        70         80         90        100        110        120 
YSDIFHVPQD VMKEFFTLIE SSSNQPLRQI QFFVLLALVA CYQLGVPSTL EQIFKQRNVL 

       130        140        150        160        170        180 
PILQRFNPEL FNRSSDNETP LFPNNSPPAS TTALNLSSNI VPSINESKIL EQEDDDVSNK 

       190        200        210        220        230        240 
SLPHAQQSII RSFPDIQKQP KGFFSYPSST VSSIAPSTLE AGNLHSQQPP KFSVDSSVDD 

       250        260        270        280        290        300 
NAITPRKPFS KIPNRLSPST QPLLSNSRHS SFRLASSSTS FPASLEMNVD IDLEPSGYFF 

       310        320        330        340        350        360 
YRHNNYIISD SSNTREVLRR YSDFFWLHSY LMKKYPFRRV PLIPLKKFHS KCFNSKQFFR 

       370        380        390        400        410        420 
TPPPGLSDFV NDLSHHPIFS NDEVVRVFFT EPNVFKNWRR ENQKRIDQEI EQFLVVPQSQ 

       430        440        450        460        470        480 
VPDASETVKE RLLKLNMSTT TAINNQLNIF RIFEKMIFTL QHFHEDFLRL QNSFNCLLDS 

       490        500        510        520        530        540 
GLYHQVFTST FAQNESKIMS MASGHFYNID SLLHQQNDAV KHTFLLGLSK EIKILISLRL 

       550        560        570        580        590        600 
LIERISEVFS TDLTKVRHTI SNDENLLRET ANSDESGRNR TFLNRSSKKR AENSLKSKKE 

       610        620        630        640        650        660 
LYLKNLNQRY QIAHELEQEL SYLQDYVFSL GNPYVEYCKQ HVKLEEESLK IWHTLESDFS 


RLET 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAB16392.2.
PIRT11628.
RefSeqNP_594197.1. NM_001019621.2.

3D structure databases

ProteinModelPortalO14120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279556. 16 interactions.
MINTMINT-4670637.
STRING4896.SPAC3A11.06-1.

Proteomic databases

MaxQBO14120.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC3A11.06.1; SPAC3A11.06.1:pep; SPAC3A11.06.
GeneID2543124.
KEGGspo:SPAC3A11.06.

Organism-specific databases

PomBaseSPAC3A11.06.

Phylogenomic databases

eggNOGCOG5391.
KOK17922.
OrthoDBEOG7B320H.
PhylomeDBO14120.

Family and domain databases

Gene3D3.30.1520.10. 1 hit.
InterProIPR001683. Phox.
[Graphical view]
PfamPF00787. PX. 1 hit.
[Graphical view]
SMARTSM00312. PX. 1 hit.
[Graphical view]
SUPFAMSSF64268. SSF64268. 1 hit.
PROSITEPS50195. PX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804151.

Entry information

Entry nameMVP1_SCHPO
AccessionPrimary (citable) accession number: O14120
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names