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Protein

Probable aminomethyltransferase, mitochondrial

Gene

gcv1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine.By similarity

Catalytic activityi

[Protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei219SubstrateBy similarity1
Binding sitei248SubstrateBy similarity1
Binding sitei385SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

ReactomeiR-SPO-6783984 Glycine degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aminomethyltransferase, mitochondrial (EC:2.1.2.10)
Alternative name(s):
Glycine cleavage system T protein
Short name:
GCVT
Gene namesi
Name:gcv1
ORF Names:n313, SPAC31G5.14
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC31G5.14
PomBaseiSPAC31G5.14 gcv1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000010765? – 387Probable aminomethyltransferase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiO14110
PaxDbiO14110
PRIDEiO14110

PTM databases

iPTMnetiO14110

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Protein-protein interaction databases

BioGridi279624, 1 interactor
STRINGi4896.SPAC31G5.14.1

Structurei

3D structure databases

ProteinModelPortaliO14110
SMRiO14110
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000239380
InParanoidiO14110
KOiK00605
OMAiMPVQYPA
OrthoDBiEOG092C3LQP
PhylomeDBiO14110

Family and domain databases

Gene3Di3.30.1360.120, 2 hits
InterProiView protein in InterPro
IPR006223 GCS_T
IPR028896 GCST/YgfZ/DmdA
IPR013977 GCV_T_C
IPR006222 GCV_T_N
IPR029043 GcvT/YgfZ_C
IPR027266 TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01571 GCV_T, 1 hit
PF08669 GCV_T_C, 1 hit
PIRSFiPIRSF006487 GcvT, 1 hit
SUPFAMiSSF101790 SSF101790, 1 hit
TIGRFAMsiTIGR00528 gcvT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRSAALSIL KRQSSTAASS SLKRTPLYDL HLKEGATIVP FAGFSMPVQY
60 70 80 90 100
KGQTISASHK WTREHSGLFD VSHMVQWFVR GENATAYLES ITPSSLKELK
110 120 130 140 150
PFHSTLSAFT NETGGIIDDT IISKQDENTY YIVTNAACSE KDEANLKKHI
160 170 180 190 200
ENWKGVELER VQGRALIAIQ GPETASVVQK LIPNVDFSVL KFGQSAYVDF
210 220 230 240 250
KGVKCLFSRS GYTGEDGFEV SIPEEVSVDF ASTLLADTRV RPIGLGARDT
260 270 280 290 300
LRLEAGMCLY GSDIDDTTSP VEGSLSWIIG KRRRKEGGFV GSSRILKELK
310 320 330 340 350
DGPSRRRVGF IVEKVPARHG SAVEVDGVEV GQVTSGCPSP TLGKNIAMGY
360 370 380
ISTGLHQVGT PAHIKVRNKL HPAQVVRMPF VETHYYK
Length:387
Mass (Da):42,408
Last modified:January 1, 1998 - v1
Checksum:i68A3CBDCFF84C45A
GO

Sequence cautioni

The sequence BAA12709 differs from that shown. Reason: Frameshift at position 305.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127E → G in BAA12709 (Ref. 1) Curated1
Sequence conflicti255A → S in BAA12709 (Ref. 1) Curated1
Sequence conflicti257 – 261MCLYG → NVAFME in BAA12709 (Ref. 1) Curated5
Sequence conflicti264I → T in BAA12709 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84656 Genomic DNA Translation: BAA12709.1 Frameshift.
CU329670 Genomic DNA Translation: CAB11698.1
PIRiT38631
RefSeqiNP_594015.1, NM_001019441.2

Genome annotation databases

EnsemblFungiiSPAC31G5.14.1; SPAC31G5.14.1:pep; SPAC31G5.14
GeneIDi2543195
KEGGispo:SPAC31G5.14

Similar proteinsi

Entry informationi

Entry nameiGCST_SCHPO
AccessioniPrimary (citable) accession number: O14110
Secondary accession number(s): Q92364
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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