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Protein

Probable aminomethyltransferase, mitochondrial

Gene

gcv1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine.By similarity

Catalytic activityi

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei219 – 2191SubstrateBy similarity
Binding sitei248 – 2481SubstrateBy similarity
Binding sitei385 – 3851SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2250-MONOMER.
ReactomeiR-SPO-6783984. Glycine degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aminomethyltransferase, mitochondrial (EC:2.1.2.10)
Alternative name(s):
Glycine cleavage system T protein
Short name:
GCVT
Gene namesi
Name:gcv1
ORF Names:n313, SPAC31G5.14
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC31G5.14.
PomBaseiSPAC31G5.14. gcv1.

Subcellular locationi

GO - Cellular componenti

  • glycine cleavage complex Source: PomBase
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 387Probable aminomethyltransferase, mitochondrialPRO_0000010765
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiO14110.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity

Protein-protein interaction databases

BioGridi279624. 1 interaction.
MINTiMINT-4670555.

Structurei

3D structure databases

ProteinModelPortaliO14110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000239380.
InParanoidiO14110.
KOiK00605.
OMAiLGWLVHL.
OrthoDBiEOG092C3LQP.
PhylomeDBiO14110.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
InterProiIPR006223. GCS_T.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRSAALSIL KRQSSTAASS SLKRTPLYDL HLKEGATIVP FAGFSMPVQY
60 70 80 90 100
KGQTISASHK WTREHSGLFD VSHMVQWFVR GENATAYLES ITPSSLKELK
110 120 130 140 150
PFHSTLSAFT NETGGIIDDT IISKQDENTY YIVTNAACSE KDEANLKKHI
160 170 180 190 200
ENWKGVELER VQGRALIAIQ GPETASVVQK LIPNVDFSVL KFGQSAYVDF
210 220 230 240 250
KGVKCLFSRS GYTGEDGFEV SIPEEVSVDF ASTLLADTRV RPIGLGARDT
260 270 280 290 300
LRLEAGMCLY GSDIDDTTSP VEGSLSWIIG KRRRKEGGFV GSSRILKELK
310 320 330 340 350
DGPSRRRVGF IVEKVPARHG SAVEVDGVEV GQVTSGCPSP TLGKNIAMGY
360 370 380
ISTGLHQVGT PAHIKVRNKL HPAQVVRMPF VETHYYK
Length:387
Mass (Da):42,408
Last modified:January 1, 1998 - v1
Checksum:i68A3CBDCFF84C45A
GO

Sequence cautioni

The sequence BAA12709 differs from that shown. Reason: Frameshift at position 305. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271E → G in BAA12709 (Ref. 1) Curated
Sequence conflicti255 – 2551A → S in BAA12709 (Ref. 1) Curated
Sequence conflicti257 – 2615MCLYG → NVAFME in BAA12709 (Ref. 1) Curated
Sequence conflicti264 – 2641I → T in BAA12709 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84656 Genomic DNA. Translation: BAA12709.1. Frameshift.
CU329670 Genomic DNA. Translation: CAB11698.1.
PIRiT38631.
RefSeqiNP_594015.1. NM_001019441.2.

Genome annotation databases

EnsemblFungiiSPAC31G5.14.1; SPAC31G5.14.1:pep; SPAC31G5.14.
GeneIDi2543195.
KEGGispo:SPAC31G5.14.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84656 Genomic DNA. Translation: BAA12709.1. Frameshift.
CU329670 Genomic DNA. Translation: CAB11698.1.
PIRiT38631.
RefSeqiNP_594015.1. NM_001019441.2.

3D structure databases

ProteinModelPortaliO14110.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279624. 1 interaction.
MINTiMINT-4670555.

Proteomic databases

MaxQBiO14110.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC31G5.14.1; SPAC31G5.14.1:pep; SPAC31G5.14.
GeneIDi2543195.
KEGGispo:SPAC31G5.14.

Organism-specific databases

EuPathDBiFungiDB:SPAC31G5.14.
PomBaseiSPAC31G5.14. gcv1.

Phylogenomic databases

HOGENOMiHOG000239380.
InParanoidiO14110.
KOiK00605.
OMAiLGWLVHL.
OrthoDBiEOG092C3LQP.
PhylomeDBiO14110.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2250-MONOMER.
ReactomeiR-SPO-6783984. Glycine degradation.

Miscellaneous databases

PROiO14110.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
InterProiIPR006223. GCS_T.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGCST_SCHPO
AccessioniPrimary (citable) accession number: O14110
Secondary accession number(s): Q92364
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.