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Protein

Putative exopolyphosphatase

Gene

SPAC2F3.11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Degradation of inorganic polyphosphates.By similarity

Catalytic activityi

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.

Cofactori

Mn2+CuratedNote: Binds 2 manganese ions per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi40 – 401Manganese 1By similarity
Metal bindingi42 – 421Manganese 2By similarity
Metal bindingi116 – 1161Manganese 1By similarity
Metal bindingi116 – 1161Manganese 2By similarity
Metal bindingi138 – 1381Manganese 2By similarity
Metal bindingi200 – 2001Manganese 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative exopolyphosphatase (EC:3.6.1.11)
Short name:
ExopolyPase
Alternative name(s):
Metaphosphatase
Gene namesi
ORF Names:SPAC2F3.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2F3.11.
PomBaseiSPAC2F3.11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • mitochondrial matrix Source: PomBase
  • nucleus Source: PomBase
  • plasma membrane Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Putative exopolyphosphatasePRO_0000158600Add
BLAST

Proteomic databases

MaxQBiO14094.
PaxDbiO14094.

Interactioni

Protein-protein interaction databases

BioGridi278344. 43 interactions.
MINTiMINT-4670429.
STRINGi4896.SPAC2F3.11.1.

Structurei

3D structure databases

ProteinModelPortaliO14094.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.Curated

Phylogenomic databases

eggNOGiCOG1227.
InParanoidiO14094.
KOiK01514.
OMAiVETVGSC.
OrthoDBiEOG7FNCH9.
PhylomeDBiO14094.

Family and domain databases

InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGRFLENG REQIRNLLLN ASTVSSAPSF SFVSGNESAD LDSCASSIVY
60 70 80 90 100
AYCLQRKQLG RIVVPFFNIP RKELRLRPEL SYLLNLASIS SDDIVFLDDI
110 120 130 140 150
VKLPKRIFSN PIYLVDHNSL DRKDLENFNG SIAGIIDHHK DEGGSLHADP
160 170 180 190 200
RIIEECGSCC TLVCRYFMPV IRSLYDSKVS ELHQTATNLA VLALGPILID
210 220 230 240 250
TGNLKNEKTT DTDVKIVNDL CSFVPKDWVR DEFFDTLKEK KKSCKGFSFD
260 270 280 290 300
DLLRRDLKQY FPDGIVVNYA SVGKGLDWIK KKRLGWEDEL KSFAEVQNSD
310 320 330 340 350
LVIVGLSLSK NDEFGRQLIL YKRTERGAGL ADSFLKLSKQ NLGLEIIEEK
360 370 380
DNGDLSMWNQ RNSAASRKKV VPLLMDSVKQ VASK
Length:384
Mass (Da):43,297
Last modified:January 1, 1998 - v1
Checksum:i643CC43C7AF185EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16267.1.
PIRiT38544.
RefSeqiNP_594390.1. NM_001019812.2.

Genome annotation databases

EnsemblFungiiSPAC2F3.11.1; SPAC2F3.11.1:pep; SPAC2F3.11.
GeneIDi2541853.
KEGGispo:SPAC2F3.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16267.1.
PIRiT38544.
RefSeqiNP_594390.1. NM_001019812.2.

3D structure databases

ProteinModelPortaliO14094.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278344. 43 interactions.
MINTiMINT-4670429.
STRINGi4896.SPAC2F3.11.1.

Proteomic databases

MaxQBiO14094.
PaxDbiO14094.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC2F3.11.1; SPAC2F3.11.1:pep; SPAC2F3.11.
GeneIDi2541853.
KEGGispo:SPAC2F3.11.

Organism-specific databases

EuPathDBiFungiDB:SPAC2F3.11.
PomBaseiSPAC2F3.11.

Phylogenomic databases

eggNOGiCOG1227.
InParanoidiO14094.
KOiK01514.
OMAiVETVGSC.
OrthoDBiEOG7FNCH9.
PhylomeDBiO14094.

Miscellaneous databases

NextBioi20802941.
PROiO14094.

Family and domain databases

InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPPX1_SCHPO
AccessioniPrimary (citable) accession number: O14094
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: January 1, 1998
Last modified: June 24, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.