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O14092

- HEM1_SCHPO

UniProt

O14092 - HEM1_SCHPO

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Protein

5-aminolevulinate synthase, mitochondrial

Gene

hem1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei152 – 1521SubstrateBy similarity
Binding sitei265 – 2651SubstrateBy similarity
Binding sitei284 – 2841SubstrateBy similarity
Binding sitei317 – 3171Pyridoxal phosphateBy similarity
Binding sitei345 – 3451Pyridoxal phosphateBy similarity
Binding sitei374 – 3741Pyridoxal phosphateBy similarity
Active sitei377 – 3771By similarity
Binding sitei406 – 4061Pyridoxal phosphateBy similarity
Binding sitei407 – 4071Pyridoxal phosphateBy similarity
Binding sitei492 – 4921SubstrateBy similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: PomBase
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: PomBase

GO - Biological processi

  1. heme biosynthetic process Source: PomBase
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_262908. Heme biosynthesis.
UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:hem1
ORF Names:SPAC2F3.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC2F3.09.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: PomBase
  2. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 5585-aminolevulinate synthase, mitochondrialPRO_0000001243
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei377 – 3771N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

MaxQBiO14092.
PaxDbiO14092.

Interactioni

Protein-protein interaction databases

BioGridi278510. 4 interactions.
MINTiMINT-4670412.
STRINGi4896.SPAC2F3.09-1.

Structurei

3D structure databases

ProteinModelPortaliO14092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000221020.
InParanoidiO14092.
KOiK00643.
OMAiHYLQSIN.
OrthoDBiEOG7HHX1P.
PhylomeDBiO14092.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14092-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERVVKLAAK HCPFVSKADP SALRRMAGAG LIRAGARCPV VRHALPVAAA
60 70 80 90 100
TGADVSRGFK SDSKQMAMEP SLDEIHLKAG VVNTGSRTCR HADAVKAAAE
110 120 130 140 150
AATTTPVTKK HQMPKHYASD LNGVGPATTP RFDYDTFYRE ELDKKHRDKS
160 170 180 190 200
YRYFNNINRL AKEYPLAHLA DPNTRVEVWC SNDYLNMGGH KKIREAMHQC
210 220 230 240 250
IETYGGGAGG TRNIAGHNQH AVRLEKSLAD LHQKPAALVF GSCYVANDAT
260 270 280 290 300
LSTLGRKLPN CIFLSDEMNH ASMINGIRNS RCEKIIFKHN DLVDLEAKLA
310 320 330 340 350
SLPLNRPKII AFESVYSMSG NVAPISEICD LAKKYGAITF LDEVHAVGMY
360 370 380 390 400
GPRGAGVAEE TPGLLSRVDI ITGTLAKSYG CVGGYIAASS TLVDMIRSLA
410 420 430 440 450
PGFIFTTSLP PHVMVGALTA VEHLKVSNVE REQQRSAVRR VKQSLSEIGI
460 470 480 490 500
PVLSNDTHIV PAMVGDAHLA KLASDSLLHD HNIYVQSINF PTVSVGTERL
510 520 530 540 550
RITPTPAHNT EHYVQSLTNA MNDVWSKFNI NRIDGWEKRG IDVGRLCKFP

VLPFTTTH
Length:558
Mass (Da):60,960
Last modified:January 1, 1998 - v1
Checksum:iC599FE2B91F3BD3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16265.1.
PIRiT38542.
RefSeqiNP_594388.1. NM_001019809.2.

Genome annotation databases

EnsemblFungiiSPAC2F3.09.1; SPAC2F3.09.1:pep; SPAC2F3.09.
GeneIDi2542028.
KEGGispo:SPAC2F3.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16265.1 .
PIRi T38542.
RefSeqi NP_594388.1. NM_001019809.2.

3D structure databases

ProteinModelPortali O14092.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278510. 4 interactions.
MINTi MINT-4670412.
STRINGi 4896.SPAC2F3.09-1.

Proteomic databases

MaxQBi O14092.
PaxDbi O14092.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC2F3.09.1 ; SPAC2F3.09.1:pep ; SPAC2F3.09 .
GeneIDi 2542028.
KEGGi spo:SPAC2F3.09.

Organism-specific databases

PomBasei SPAC2F3.09.

Phylogenomic databases

eggNOGi COG0156.
HOGENOMi HOG000221020.
InParanoidi O14092.
KOi K00643.
OMAi HYLQSIN.
OrthoDBi EOG7HHX1P.
PhylomeDBi O14092.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .
Reactomei REACT_262908. Heme biosynthesis.

Miscellaneous databases

NextBioi 20803106.
PROi O14092.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiHEM1_SCHPO
AccessioniPrimary (citable) accession number: O14092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3