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O14092

- HEM1_SCHPO

UniProt

O14092 - HEM1_SCHPO

Protein

5-aminolevulinate synthase, mitochondrial

Gene

hem1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei152 – 1521SubstrateBy similarity
    Binding sitei265 – 2651SubstrateBy similarity
    Binding sitei284 – 2841SubstrateBy similarity
    Binding sitei317 – 3171Pyridoxal phosphateBy similarity
    Binding sitei345 – 3451Pyridoxal phosphateBy similarity
    Binding sitei374 – 3741Pyridoxal phosphateBy similarity
    Active sitei377 – 3771By similarity
    Binding sitei406 – 4061Pyridoxal phosphateBy similarity
    Binding sitei407 – 4071Pyridoxal phosphateBy similarity
    Binding sitei492 – 4921SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: PomBase
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: PomBase

    GO - Biological processi

    1. heme biosynthetic process Source: PomBase
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
    Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-ALA synthase
    Delta-aminolevulinate synthase
    Gene namesi
    Name:hem1
    ORF Names:SPAC2F3.09
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC2F3.09.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: PomBase
    2. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 5585-aminolevulinate synthase, mitochondrialPRO_0000001243
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei377 – 3771N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    MaxQBiO14092.
    PaxDbiO14092.

    Interactioni

    Protein-protein interaction databases

    BioGridi278510. 6 interactions.
    MINTiMINT-4670412.
    STRINGi4896.SPAC2F3.09-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO14092.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000221020.
    KOiK00643.
    OMAiHYLQSIN.
    OrthoDBiEOG7HHX1P.
    PhylomeDBiO14092.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O14092-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERVVKLAAK HCPFVSKADP SALRRMAGAG LIRAGARCPV VRHALPVAAA    50
    TGADVSRGFK SDSKQMAMEP SLDEIHLKAG VVNTGSRTCR HADAVKAAAE 100
    AATTTPVTKK HQMPKHYASD LNGVGPATTP RFDYDTFYRE ELDKKHRDKS 150
    YRYFNNINRL AKEYPLAHLA DPNTRVEVWC SNDYLNMGGH KKIREAMHQC 200
    IETYGGGAGG TRNIAGHNQH AVRLEKSLAD LHQKPAALVF GSCYVANDAT 250
    LSTLGRKLPN CIFLSDEMNH ASMINGIRNS RCEKIIFKHN DLVDLEAKLA 300
    SLPLNRPKII AFESVYSMSG NVAPISEICD LAKKYGAITF LDEVHAVGMY 350
    GPRGAGVAEE TPGLLSRVDI ITGTLAKSYG CVGGYIAASS TLVDMIRSLA 400
    PGFIFTTSLP PHVMVGALTA VEHLKVSNVE REQQRSAVRR VKQSLSEIGI 450
    PVLSNDTHIV PAMVGDAHLA KLASDSLLHD HNIYVQSINF PTVSVGTERL 500
    RITPTPAHNT EHYVQSLTNA MNDVWSKFNI NRIDGWEKRG IDVGRLCKFP 550
    VLPFTTTH 558
    Length:558
    Mass (Da):60,960
    Last modified:January 1, 1998 - v1
    Checksum:iC599FE2B91F3BD3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16265.1.
    PIRiT38542.
    RefSeqiNP_594388.1. NM_001019809.2.

    Genome annotation databases

    EnsemblFungiiSPAC2F3.09.1; SPAC2F3.09.1:pep; SPAC2F3.09.
    GeneIDi2542028.
    KEGGispo:SPAC2F3.09.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB16265.1 .
    PIRi T38542.
    RefSeqi NP_594388.1. NM_001019809.2.

    3D structure databases

    ProteinModelPortali O14092.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278510. 6 interactions.
    MINTi MINT-4670412.
    STRINGi 4896.SPAC2F3.09-1.

    Proteomic databases

    MaxQBi O14092.
    PaxDbi O14092.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC2F3.09.1 ; SPAC2F3.09.1:pep ; SPAC2F3.09 .
    GeneIDi 2542028.
    KEGGi spo:SPAC2F3.09.

    Organism-specific databases

    PomBasei SPAC2F3.09.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000221020.
    KOi K00643.
    OMAi HYLQSIN.
    OrthoDBi EOG7HHX1P.
    PhylomeDBi O14092.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .

    Miscellaneous databases

    NextBioi 20803106.
    PROi O14092.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiHEM1_SCHPO
    AccessioniPrimary (citable) accession number: O14092
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3