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Protein

Importin subunit beta-2

Gene

kap104

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit beta-2By similarity
Alternative name(s):
Importin-104By similarity
Karyopherin subunit beta-2By similarity
Karyopherin-104By similarity
TransportinBy similarity
Short name:
TRNBy similarity
Gene namesi
Name:kap1041 Publication
ORF Names:SPAC2F3.06cImported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2F3.06c.
PomBaseiSPAC2F3.06c. kap104.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
  • mitotic spindle midzone Source: PomBase
  • nuclear envelope Source: PomBase
  • nuclear membrane Source: GO_Central
  • nuclear periphery Source: PomBase
  • nuclear pore Source: PomBase
  • nucleus Source: PomBase
  • protein complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Severely impaired growth at 32 degrees Celsius.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 910910Importin subunit beta-2PRO_0000120769Add
BLAST

Proteomic databases

MaxQBiO14089.

Interactioni

Subunit structurei

Interacts with Ran; interacts specifically with the GTP-bound form of Ran (GTP-Ran), protecting it from GTP hydrolysis and nucleotide exchange. Interacts with nucleoporins.By similarity

Protein-protein interaction databases

BioGridi278527. 1 interaction.
MINTiMINT-4670377.

Structurei

3D structure databases

ProteinModelPortaliO14089.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati12 – 3928HEAT 1By similarityAdd
BLAST
Domaini34 – 12289Importin N-terminalCuratedAdd
BLAST
Repeati44 – 8239HEAT 2By similarityAdd
BLAST
Repeati93 – 12634HEAT 3By similarityAdd
BLAST
Repeati132 – 16938HEAT 4By similarityAdd
BLAST
Repeati177 – 20731HEAT 5By similarityAdd
BLAST
Repeati220 – 24728HEAT 6By similarityAdd
BLAST
Repeati259 – 28628HEAT 7By similarityAdd
BLAST
Repeati302 – 406105HEAT 8By similarityAdd
BLAST
Repeati414 – 44229HEAT 9By similarityAdd
BLAST
Repeati454 – 48128HEAT 10By similarityAdd
BLAST
Repeati499 – 53234HEAT 11By similarityAdd
BLAST
Repeati540 – 57334HEAT 12By similarityAdd
BLAST
Repeati581 – 61939HEAT 13By similarityAdd
BLAST
Repeati627 – 67751HEAT 14By similarityAdd
BLAST
Repeati690 – 72132HEAT 15By similarityAdd
BLAST
Repeati729 – 76436HEAT 16By similarityAdd
BLAST
Repeati772 – 80736HEAT 17By similarityAdd
BLAST
Repeati815 – 84834HEAT 18By similarityAdd
BLAST
Repeati857 – 88832HEAT 19By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi366 – 38520Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Contains 19 HEAT repeats.By similarity
Contains 1 importin N-terminal domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000203940.
InParanoidiO14089.
KOiK18752.
OMAiGEIAMQH.
OrthoDBiEOG092C0UPN.
PhylomeDBiO14089.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

O14089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDNPWVLQE QVLVELSEVI KNSLSENSQT RNAALNLLEK AKDIPDLNNY
60 70 80 90 100
LTCILINATE LSVSIRSAAG LLLKNNVRVS SLESGSGLQS LDYTKSTVIR
110 120 130 140 150
GLCDPEQLIR GISGNVITTI ISRWGISTWP EVLPQLMEML SSPASTTQEG
160 170 180 190 200
AFSALTKICE DSAQELDRDF NGTRPLDFMI PRFIELARHE NPKIRTDALF
210 220 230 240 250
CLNQFVLIQS QSLYAHIDTF LETCYALATD VSPNVRKNVC QALVYLLDVR
260 270 280 290 300
PDKIAPSLGS IVEYMLYSTQ DSDQNVALEA CEFWLAIAEQ PDLCSALGPY
310 320 330 340 350
LDKIVPMLLQ GMVYSDMDLL LLGNDADDYD VEDREEDIRP QHAKGKSRIT
360 370 380 390 400
LNTQGPITQQ GSSNADADEL EDEDEDDDEF DEDDDAFMDW NLRKCSAAAL
410 420 430 440 450
DVLSSFWKQR LLEIILPHLK QSLTSEDWKV QEAGVLAVGA IAEGCMDGMV
460 470 480 490 500
QYLPELYPYF LSLLDSKKPL VRTITCWTLG RYSKWASCLE SEEDRQKYFV
510 520 530 540 550
PLLQGLLRMV VDNNKKVQEA GCSAFAILEE QAGPSLVPYL EPILTNLAFA
560 570 580 590 600
FQKYQRKNVL ILYDAVQTLA DYVGSALNDK RYIELLITPL LQKWSMIPDD
610 620 630 640 650
DPNLFPLFEC LSSVAVALRD GFAPFAAETY ARTFRILRNT LYLITTAQND
660 670 680 690 700
PTVDVPDRDF LVTTLDLVSG IIQALGSQVS PLLAQADPPL GQIIGICAKD
710 720 730 740 750
EVPEVRQSAY ALLGDMCMYC FDQIRPYCDA LLVDMLPQMQ LPLLHVSASN
760 770 780 790 800
NAIWSAGEMA LQLGKDMQQW VKPLLERLIC ILKSKKSNTT VLENVAITIG
810 820 830 840 850
RLGVYNPELV APHLELFYQP WFEIIKTVGE NEEKDSAFRG FCNILACNPQ
860 870 880 890 900
ALSYLLPMFV LCVAEYENPS AELRDMFQKI LQGSVELFNG KASWQASPEV
910
LAQIQAQYGV
Length:910
Mass (Da):101,718
Last modified:January 1, 1998 - v1
Checksum:i4939CD9B09877208
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16272.1.
PIRiT38539.
RefSeqiNP_594385.1. NM_001019806.2.

Genome annotation databases

EnsemblFungiiSPAC2F3.06c.1; SPAC2F3.06c.1:pep; SPAC2F3.06c.
GeneIDi2542046.
KEGGispo:SPAC2F3.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16272.1.
PIRiT38539.
RefSeqiNP_594385.1. NM_001019806.2.

3D structure databases

ProteinModelPortaliO14089.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278527. 1 interaction.
MINTiMINT-4670377.

Proteomic databases

MaxQBiO14089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC2F3.06c.1; SPAC2F3.06c.1:pep; SPAC2F3.06c.
GeneIDi2542046.
KEGGispo:SPAC2F3.06c.

Organism-specific databases

EuPathDBiFungiDB:SPAC2F3.06c.
PomBaseiSPAC2F3.06c. kap104.

Phylogenomic databases

HOGENOMiHOG000203940.
InParanoidiO14089.
KOiK18752.
OMAiGEIAMQH.
OrthoDBiEOG092C0UPN.
PhylomeDBiO14089.

Miscellaneous databases

PROiO14089.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIMB2_SCHPO
AccessioniPrimary (citable) accession number: O14089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.