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Protein

Putative 2-hydroxyacid dehydrogenase UNK4.10

Gene

SPAC2E11.10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei246By similarity1
Binding sitei270NADBy similarity1
Active sitei275By similarity1
Active sitei293Proton donorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi166 – 167NADBy similarity2
Nucleotide bindingi244 – 246NADBy similarity3
Nucleotide bindingi293 – 296NADBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-SPO-389661 Glyoxylate metabolism and glycine degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-hydroxyacid dehydrogenase UNK4.10 (EC:1.-.-.-)
Gene namesi
ORF Names:SPAC2E11.10, SPACUNK4.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPACUNK4.10
PomBaseiSPACUNK4.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760381 – 334Putative 2-hydroxyacid dehydrogenase UNK4.10Add BLAST334

Proteomic databases

MaxQBiO14075
PaxDbiO14075
PRIDEiO14075

PTM databases

iPTMnetiO14075

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi279048, 10 interactors
STRINGi4896.SPACUNK4.10.1

Structurei

3D structure databases

ProteinModelPortaliO14075
SMRiO14075
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000136700
InParanoidiO14075
KOiK00015
OMAiNTARGKS
OrthoDBiEOG092C4Y4L
PhylomeDBiO14075

Family and domain databases

InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR029752 D-isomer_DH_CS1
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00065 D_2_HYDROXYACID_DH_1, 1 hit
PS00670 D_2_HYDROXYACID_DH_2, 1 hit
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

Sequencei

Sequence statusi: Complete.

O14075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSGKPAAL LVGTLKHAHK EWEALGKYAE LKTYSDGTRE DFLAKCKTEF
60 70 80 90 100
QNVKAICRTY NSKFYMGIFD KEIIDNLPPS VKFICHLGAG YETVDVAACT
110 120 130 140 150
ARGIQVSHVP KAVDDATADV GIFLMLGALR GFNQGIFELH KNNWNANCKP
160 170 180 190 200
SHDPEGKTLG ILGLGGIGKT MAKRARAFDM KIVYHNRTPL PEEEAEGAEF
210 220 230 240 250
VSFDDLLAKS DVLSLNLPLN AHTRHIIGKP EFQKMKRGIV IVNTARGAVM
260 270 280 290 300
DEAALVEALD EGIVYSAGLD VFEEEPKIHP GLLENEKVIL LPHLGTNSLE
310 320 330
TQYKMECAVL MNVKNGIVND SLPNLVPEQR GDIE
Length:334
Mass (Da):36,701
Last modified:January 1, 1998 - v1
Checksum:i493BB4A28DDB4BFF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69F → W in BAA13847 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89185 mRNA Translation: BAA13847.1
CU329670 Genomic DNA Translation: CAA20140.1
PIRiT41705
T42743
RefSeqiNP_593968.1, NM_001019395.2

Genome annotation databases

EnsemblFungiiSPACUNK4.10.1; SPACUNK4.10.1:pep; SPACUNK4.10
GeneIDi2542594
KEGGispo:SPACUNK4.10

Similar proteinsi

Entry informationi

Entry nameiYEAA_SCHPO
AccessioniPrimary (citable) accession number: O14075
Secondary accession number(s): P78836
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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