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O14075 (YEAA_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative 2-hydroxyacid dehydrogenase UNK4.10
EC=1.-.-.-
Gene names
ORF Names:SPAC2E11.10, SPACUNK4.10
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglyoxylate catabolic process

Inferred from sequence orthology. Source: PomBase

regulation of gluconeogenesis

Inferred by curator. Source: PomBase

   Cellular_componentcytosol

Inferred from direct assay PubMed 16823372. Source: PomBase

nucleus

Inferred from direct assay PubMed 16823372. Source: PomBase

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

glyoxylate reductase activity

Inferred from sequence orthology. Source: PomBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Putative 2-hydroxyacid dehydrogenase UNK4.10
PRO_0000076038

Regions

Nucleotide binding166 – 1672NAD By similarity
Nucleotide binding244 – 2463NAD By similarity
Nucleotide binding293 – 2964NAD By similarity

Sites

Active site2461 By similarity
Active site2751 By similarity
Active site2931Proton donor By similarity
Binding site2701NAD By similarity

Experimental info

Sequence conflict691F → W in BAA13847. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O14075 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 493BB4A28DDB4BFF

FASTA33436,701
        10         20         30         40         50         60 
MTLSGKPAAL LVGTLKHAHK EWEALGKYAE LKTYSDGTRE DFLAKCKTEF QNVKAICRTY 

        70         80         90        100        110        120 
NSKFYMGIFD KEIIDNLPPS VKFICHLGAG YETVDVAACT ARGIQVSHVP KAVDDATADV 

       130        140        150        160        170        180 
GIFLMLGALR GFNQGIFELH KNNWNANCKP SHDPEGKTLG ILGLGGIGKT MAKRARAFDM 

       190        200        210        220        230        240 
KIVYHNRTPL PEEEAEGAEF VSFDDLLAKS DVLSLNLPLN AHTRHIIGKP EFQKMKRGIV 

       250        260        270        280        290        300 
IVNTARGAVM DEAALVEALD EGIVYSAGLD VFEEEPKIHP GLLENEKVIL LPHLGTNSLE 

       310        320        330 
TQYKMECAVL MNVKNGIVND SLPNLVPEQR GDIE

« Hide

References

[1]"Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: PR745.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D89185 mRNA. Translation: BAA13847.1.
CU329670 Genomic DNA. Translation: CAA20140.1.
PIRT41705.
T42743.
RefSeqNP_593968.1. NM_001019395.2.

3D structure databases

ProteinModelPortalO14075.
ModBaseSearch...

Protein-protein interaction databases

STRING4896.SPACUNK4.10-1.

Proteomic databases

PaxDbO14075.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPACUNK4.10.1; SPACUNK4.10.1:pep; SPACUNK4.10.
GeneID2542594.
KEGGspo:SPACUNK4.10.

Organism-specific databases

PomBaseSPACUNK4.10.

Phylogenomic databases

eggNOGCOG1052.
HOGENOMHOG000136700.
OMAITNISRT.
OrthoDBEOG4MWCG7.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20803643.

Entry information

Entry nameYEAA_SCHPO
AccessionPrimary (citable) accession number: O14075
Secondary accession number(s): P78836
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 1, 1998
Last modified: April 3, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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