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O14075

- YEAA_SCHPO

UniProt

O14075 - YEAA_SCHPO

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Protein

Putative 2-hydroxyacid dehydrogenase UNK4.10

Gene

SPAC2E11.10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei246 – 2461By similarity
Binding sitei270 – 2701NADBy similarity
Active sitei275 – 2751By similarity
Active sitei293 – 2931Proton donorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi166 – 1672NADBy similarity
Nucleotide bindingi244 – 2463NADBy similarity
Nucleotide bindingi293 – 2964NADBy similarity

GO - Molecular functioni

  1. glyoxylate reductase activity Source: PomBase
  2. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate catabolic process Source: PomBase
  2. regulation of gluconeogenesis Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-hydroxyacid dehydrogenase UNK4.10 (EC:1.-.-.-)
Gene namesi
ORF Names:SPAC2E11.10, SPACUNK4.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPACUNK4.10.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Putative 2-hydroxyacid dehydrogenase UNK4.10PRO_0000076038Add
BLAST

Proteomic databases

MaxQBiO14075.
PaxDbiO14075.

Interactioni

Protein-protein interaction databases

BioGridi279048. 9 interactions.
MINTiMINT-4670259.
STRINGi4896.SPACUNK4.10-1.

Structurei

3D structure databases

ProteinModelPortaliO14075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136700.
InParanoidiO14075.
OMAiTKMEEWA.
OrthoDBiEOG7C5MKX.
PhylomeDBiO14075.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14075-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLSGKPAAL LVGTLKHAHK EWEALGKYAE LKTYSDGTRE DFLAKCKTEF
60 70 80 90 100
QNVKAICRTY NSKFYMGIFD KEIIDNLPPS VKFICHLGAG YETVDVAACT
110 120 130 140 150
ARGIQVSHVP KAVDDATADV GIFLMLGALR GFNQGIFELH KNNWNANCKP
160 170 180 190 200
SHDPEGKTLG ILGLGGIGKT MAKRARAFDM KIVYHNRTPL PEEEAEGAEF
210 220 230 240 250
VSFDDLLAKS DVLSLNLPLN AHTRHIIGKP EFQKMKRGIV IVNTARGAVM
260 270 280 290 300
DEAALVEALD EGIVYSAGLD VFEEEPKIHP GLLENEKVIL LPHLGTNSLE
310 320 330
TQYKMECAVL MNVKNGIVND SLPNLVPEQR GDIE
Length:334
Mass (Da):36,701
Last modified:January 1, 1998 - v1
Checksum:i493BB4A28DDB4BFF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti69 – 691F → W in BAA13847. (PubMed:9501991)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89185 mRNA. Translation: BAA13847.1.
CU329670 Genomic DNA. Translation: CAA20140.1.
PIRiT41705.
T42743.
RefSeqiNP_593968.1. NM_001019395.2.

Genome annotation databases

EnsemblFungiiSPACUNK4.10.1; SPACUNK4.10.1:pep; SPACUNK4.10.
GeneIDi2542594.
KEGGispo:SPACUNK4.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89185 mRNA. Translation: BAA13847.1 .
CU329670 Genomic DNA. Translation: CAA20140.1 .
PIRi T41705.
T42743.
RefSeqi NP_593968.1. NM_001019395.2.

3D structure databases

ProteinModelPortali O14075.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279048. 9 interactions.
MINTi MINT-4670259.
STRINGi 4896.SPACUNK4.10-1.

Proteomic databases

MaxQBi O14075.
PaxDbi O14075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPACUNK4.10.1 ; SPACUNK4.10.1:pep ; SPACUNK4.10 .
GeneIDi 2542594.
KEGGi spo:SPACUNK4.10.

Organism-specific databases

PomBasei SPACUNK4.10.

Phylogenomic databases

eggNOGi COG1052.
HOGENOMi HOG000136700.
InParanoidi O14075.
OMAi TKMEEWA.
OrthoDBi EOG7C5MKX.
PhylomeDBi O14075.

Miscellaneous databases

NextBioi 20803643.
PROi O14075.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view ]
PROSITEi PS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: PR745.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiYEAA_SCHPO
AccessioniPrimary (citable) accession number: O14075
Secondary accession number(s): P78836
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3