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O14075

- YEAA_SCHPO

UniProt

O14075 - YEAA_SCHPO

Protein

Putative 2-hydroxyacid dehydrogenase UNK4.10

Gene

SPAC2E11.10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei246 – 2461By similarity
    Binding sitei270 – 2701NADBy similarity
    Active sitei275 – 2751By similarity
    Active sitei293 – 2931Proton donorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi166 – 1672NADBy similarity
    Nucleotide bindingi244 – 2463NADBy similarity
    Nucleotide bindingi293 – 2964NADBy similarity

    GO - Molecular functioni

    1. glyoxylate reductase activity Source: PomBase
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate catabolic process Source: PomBase
    2. regulation of gluconeogenesis Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-hydroxyacid dehydrogenase UNK4.10 (EC:1.-.-.-)
    Gene namesi
    ORF Names:SPAC2E11.10, SPACUNK4.10
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPACUNK4.10.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334Putative 2-hydroxyacid dehydrogenase UNK4.10PRO_0000076038Add
    BLAST

    Proteomic databases

    MaxQBiO14075.
    PaxDbiO14075.

    Interactioni

    Protein-protein interaction databases

    BioGridi279048. 9 interactions.
    MINTiMINT-4670259.
    STRINGi4896.SPACUNK4.10-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO14075.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1052.
    HOGENOMiHOG000136700.
    OMAiTKMEEWA.
    OrthoDBiEOG7C5MKX.
    PhylomeDBiO14075.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view]
    PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
    PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14075-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLSGKPAAL LVGTLKHAHK EWEALGKYAE LKTYSDGTRE DFLAKCKTEF    50
    QNVKAICRTY NSKFYMGIFD KEIIDNLPPS VKFICHLGAG YETVDVAACT 100
    ARGIQVSHVP KAVDDATADV GIFLMLGALR GFNQGIFELH KNNWNANCKP 150
    SHDPEGKTLG ILGLGGIGKT MAKRARAFDM KIVYHNRTPL PEEEAEGAEF 200
    VSFDDLLAKS DVLSLNLPLN AHTRHIIGKP EFQKMKRGIV IVNTARGAVM 250
    DEAALVEALD EGIVYSAGLD VFEEEPKIHP GLLENEKVIL LPHLGTNSLE 300
    TQYKMECAVL MNVKNGIVND SLPNLVPEQR GDIE 334
    Length:334
    Mass (Da):36,701
    Last modified:January 1, 1998 - v1
    Checksum:i493BB4A28DDB4BFF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 691F → W in BAA13847. (PubMed:9501991)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89185 mRNA. Translation: BAA13847.1.
    CU329670 Genomic DNA. Translation: CAA20140.1.
    PIRiT41705.
    T42743.
    RefSeqiNP_593968.1. NM_001019395.2.

    Genome annotation databases

    EnsemblFungiiSPACUNK4.10.1; SPACUNK4.10.1:pep; SPACUNK4.10.
    GeneIDi2542594.
    KEGGispo:SPACUNK4.10.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89185 mRNA. Translation: BAA13847.1 .
    CU329670 Genomic DNA. Translation: CAA20140.1 .
    PIRi T41705.
    T42743.
    RefSeqi NP_593968.1. NM_001019395.2.

    3D structure databases

    ProteinModelPortali O14075.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279048. 9 interactions.
    MINTi MINT-4670259.
    STRINGi 4896.SPACUNK4.10-1.

    Proteomic databases

    MaxQBi O14075.
    PaxDbi O14075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPACUNK4.10.1 ; SPACUNK4.10.1:pep ; SPACUNK4.10 .
    GeneIDi 2542594.
    KEGGi spo:SPACUNK4.10.

    Organism-specific databases

    PomBasei SPACUNK4.10.

    Phylogenomic databases

    eggNOGi COG1052.
    HOGENOMi HOG000136700.
    OMAi TKMEEWA.
    OrthoDBi EOG7C5MKX.
    PhylomeDBi O14075.

    Miscellaneous databases

    NextBioi 20803643.
    PROi O14075.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00065. D_2_HYDROXYACID_DH_1. 1 hit.
    PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
    PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
      Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
      DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: PR745.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiYEAA_SCHPO
    AccessioniPrimary (citable) accession number: O14075
    Secondary accession number(s): P78836
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3