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Protein

Putative 2-hydroxyacid dehydrogenase UNK4.10

Gene

SPAC2E11.10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei246By similarity1
Binding sitei270NADBy similarity1
Active sitei275By similarity1
Active sitei293Proton donorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi166 – 167NADBy similarity2
Nucleotide bindingi244 – 246NADBy similarity3
Nucleotide bindingi293 – 296NADBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-SPO-977347. Serine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-hydroxyacid dehydrogenase UNK4.10 (EC:1.-.-.-)
Gene namesi
ORF Names:SPAC2E11.10, SPACUNK4.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPACUNK4.10.
PomBaseiSPACUNK4.10.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760381 – 334Putative 2-hydroxyacid dehydrogenase UNK4.10Add BLAST334

Proteomic databases

MaxQBiO14075.
PRIDEiO14075.

Interactioni

Protein-protein interaction databases

BioGridi279048. 10 interactors.
MINTiMINT-4670259.

Structurei

3D structure databases

ProteinModelPortaliO14075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000136700.
InParanoidiO14075.
OMAiRIMEPAI.
OrthoDBiEOG092C4Y4L.
PhylomeDBiO14075.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSGKPAAL LVGTLKHAHK EWEALGKYAE LKTYSDGTRE DFLAKCKTEF
60 70 80 90 100
QNVKAICRTY NSKFYMGIFD KEIIDNLPPS VKFICHLGAG YETVDVAACT
110 120 130 140 150
ARGIQVSHVP KAVDDATADV GIFLMLGALR GFNQGIFELH KNNWNANCKP
160 170 180 190 200
SHDPEGKTLG ILGLGGIGKT MAKRARAFDM KIVYHNRTPL PEEEAEGAEF
210 220 230 240 250
VSFDDLLAKS DVLSLNLPLN AHTRHIIGKP EFQKMKRGIV IVNTARGAVM
260 270 280 290 300
DEAALVEALD EGIVYSAGLD VFEEEPKIHP GLLENEKVIL LPHLGTNSLE
310 320 330
TQYKMECAVL MNVKNGIVND SLPNLVPEQR GDIE
Length:334
Mass (Da):36,701
Last modified:January 1, 1998 - v1
Checksum:i493BB4A28DDB4BFF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69F → W in BAA13847 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89185 mRNA. Translation: BAA13847.1.
CU329670 Genomic DNA. Translation: CAA20140.1.
PIRiT41705.
T42743.
RefSeqiNP_593968.1. NM_001019395.2.

Genome annotation databases

EnsemblFungiiSPACUNK4.10.1; SPACUNK4.10.1:pep; SPACUNK4.10.
GeneIDi2542594.
KEGGispo:SPACUNK4.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89185 mRNA. Translation: BAA13847.1.
CU329670 Genomic DNA. Translation: CAA20140.1.
PIRiT41705.
T42743.
RefSeqiNP_593968.1. NM_001019395.2.

3D structure databases

ProteinModelPortaliO14075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279048. 10 interactors.
MINTiMINT-4670259.

Proteomic databases

MaxQBiO14075.
PRIDEiO14075.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPACUNK4.10.1; SPACUNK4.10.1:pep; SPACUNK4.10.
GeneIDi2542594.
KEGGispo:SPACUNK4.10.

Organism-specific databases

EuPathDBiFungiDB:SPACUNK4.10.
PomBaseiSPACUNK4.10.

Phylogenomic databases

HOGENOMiHOG000136700.
InParanoidiO14075.
OMAiRIMEPAI.
OrthoDBiEOG092C4Y4L.
PhylomeDBiO14075.

Enzyme and pathway databases

ReactomeiR-SPO-977347. Serine biosynthesis.

Miscellaneous databases

PROiO14075.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYEAA_SCHPO
AccessioniPrimary (citable) accession number: O14075
Secondary accession number(s): P78836
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.