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Protein

Manganese-transporting ATPase 4

Gene

cta4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity). Involved in controlling nuclear calcium ion levels. Required for cytokinesis and stabilizing microtubules.By similarity1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei485 – 48514-aspartylphosphate intermediateBy similarity
Metal bindingi824 – 8241MagnesiumBy similarity
Metal bindingi828 – 8281MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

  • calcium ion transmembrane transport Source: PomBase
  • cellular calcium ion homeostasis Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Manganese-transporting ATPase 4 (EC:3.6.3.-)
Gene namesi
Name:cta4
ORF Names:SPAC2E11.07c, SPACUNK4.07c, SPAPYUK71.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPACUNK4.07c.
PomBaseiSPACUNK4.07c. cta4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence analysisAdd
BLAST
Transmembranei24 – 4421HelicalSequence analysisAdd
BLAST
Topological domaini45 – 5410ExtracellularSequence analysis
Transmembranei55 – 7521HelicalSequence analysisAdd
BLAST
Topological domaini76 – 191116CytoplasmicSequence analysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Topological domaini213 – 2164ExtracellularSequence analysis
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Topological domaini238 – 397160CytoplasmicSequence analysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence analysisAdd
BLAST
Topological domaini419 – 1057639ExtracellularSequence analysisAdd
BLAST
Transmembranei1058 – 107821HelicalSequence analysisAdd
BLAST
Topological domaini1079 – 110022CytoplasmicSequence analysisAdd
BLAST
Transmembranei1101 – 112121HelicalSequence analysisAdd
BLAST
Topological domaini1122 – 113615ExtracellularSequence analysisAdd
BLAST
Transmembranei1137 – 115721HelicalSequence analysisAdd
BLAST
Topological domaini1158 – 117417CytoplasmicSequence analysisAdd
BLAST
Transmembranei1175 – 119521HelicalSequence analysisAdd
BLAST
Topological domaini1196 – 121116ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12111211Manganese-transporting ATPase 4PRO_0000046350Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14072.
PRIDEiO14072.

Interactioni

Protein-protein interaction databases

BioGridi278845. 2 interactions.
MINTiMINT-4670228.

Structurei

3D structure databases

ProteinModelPortaliO14072.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000199432.
InParanoidiO14072.
KOiK14950.
OMAiCHVAGEL.
OrthoDBiEOG092C0IZK.
PhylomeDBiO14072.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF82. PTHR24093:SF82. 3 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14072-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKALITSP DISSGQLYIK LPTFFHLYVW PFALFVYPYI GYVYQNKLYS
60 70 80 90 100
EEVRYLTYIA VGTIHALFWL AGEWNTKVYC LMTCRKTDKV EQATHILVTP
110 120 130 140 150
SKIGESSSVE PITKLVLPDS QTIQYSFSFQ RKRFIYEPEK GCFANITFPM
160 170 180 190 200
DEPSTIGTLK KSTGLTNIQS EIFLYRYGKN CFDIPIPTFG TLFKEHAVAP
210 220 230 240 250
FFVFQIFCCV LWCLDDYWYF SLFSMFMIIA LECSVVWQRQ RTLTEFRTMS
260 270 280 290 300
IKPYEIQVYR NKHWFPISTE DLLPNDVVSV LHNKEDSGLP CDLLLLSGSC
310 320 330 340 350
VVNEAMLSGE STPLVKESIE LRPEEAVIDV DELDKNAVLF GGTRVLQVTQ
360 370 380 390 400
SPFCKLKTPD NGVPAIVLRT GFETSQGSLV RTMVFSSEKV TANNRESLYF
410 420 430 440 450
ILFLLVFAIA ASGYVWHVGS KTERSRYKLM LDCVMIITSV VPSELPMELS
460 470 480 490 500
MAVNASLGAL SKYYIYCTEP FRIPLSGHLD ICCFDKTGTL TEEHMVVQGI
510 520 530 540 550
AGVNRKDPYS LEKLSDASND AILAIATAHT LVLLEQEGET PKVVGDPMEK
560 570 580 590 600
ATVENLGWSI EKKNFVSAPE GSVFYKGKVQ IIRNFQFSSA LKRQSSVSNV
610 620 630 640 650
RVSGGSFKTF VSVKGAPEVI ATMLREVPKD YEKIYKDYGR KGSRVLALGY
660 670 680 690 700
KYFKNYIPEN QVSDLSRESI ESDLVFAGFL IFTSPLKEDA RQTVQMLNNS
710 720 730 740 750
SHRCMMITGD NPLTAVYVAE QVGIVEKPTL VLDIKHENEK ILEWKSTDDT
760 770 780 790 800
INLPMNPHKS LEASLYEKYD LCITGRALSQ IINPDVIMSI FTHAWVYARV
810 820 830 840 850
SPSQKEFMIS TLKHNGYITL MCGDGTNDVG ALKQAHVGVA LLNASEEDML
860 870 880 890 900
EMQERARNQK LMGVYEKQIQ LAKRFNLPTP PVPPALCHAF PPGPNNPHRE
910 920 930 940 950
KTQEGLNKVL EDLETKKASD VQLTEAEKAA ERRANLANKM FDTLANASDD
960 970 980 990 1000
EAPKLKLGDA SVAAPFTSKL AVVSSITNIV RQGRCTLVAL VQMHKILALN
1010 1020 1030 1040 1050
CLITAYSLSV LHLDGIKFGD TQYTISGMLM SVCFYCVSRA RPLETLSKER
1060 1070 1080 1090 1100
PQAGIFNTYI IGSVLGQFAI HIVTLIYITR VVYLYEDPLE KVDLEETFKP
1110 1120 1130 1140 1150
SLLNTAIYLL QLIQQVSTFA INYQGRPFRE ALSENKGMYY GLLGIAFVAI
1160 1170 1180 1190 1200
AGVTEFSPEL NAKLQLVKMA YNFQIQLLAT MVVDYAACWI IEELMKKYFR
1210
DNKPKEIVLR N
Length:1,211
Mass (Da):136,261
Last modified:January 1, 1998 - v1
Checksum:i6FEE4228CA5A57EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA20137.1.
AB027853 Genomic DNA. Translation: BAA87157.1.
PIRiT41702.
RefSeqiNP_593971.1. NM_001019398.2.

Genome annotation databases

EnsemblFungiiSPACUNK4.07c.1; SPACUNK4.07c.1:pep; SPACUNK4.07c.
GeneIDi2542381.
KEGGispo:SPACUNK4.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA20137.1.
AB027853 Genomic DNA. Translation: BAA87157.1.
PIRiT41702.
RefSeqiNP_593971.1. NM_001019398.2.

3D structure databases

ProteinModelPortaliO14072.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278845. 2 interactions.
MINTiMINT-4670228.

Proteomic databases

MaxQBiO14072.
PRIDEiO14072.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPACUNK4.07c.1; SPACUNK4.07c.1:pep; SPACUNK4.07c.
GeneIDi2542381.
KEGGispo:SPACUNK4.07c.

Organism-specific databases

EuPathDBiFungiDB:SPACUNK4.07c.
PomBaseiSPACUNK4.07c. cta4.

Phylogenomic databases

HOGENOMiHOG000199432.
InParanoidiO14072.
KOiK14950.
OMAiCHVAGEL.
OrthoDBiEOG092C0IZK.
PhylomeDBiO14072.

Enzyme and pathway databases

ReactomeiR-SPO-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiO14072.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF82. PTHR24093:SF82. 3 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATC4_SCHPO
AccessioniPrimary (citable) accession number: O14072
Secondary accession number(s): Q9USD0, Q9UT01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.