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Protein

Protein bir1

Gene

bir1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Seems to act in the pleiotropic control of cell division. Has a role in chromosome segregation by recruiting condensin and ark1 kinase to appropriate sites as the cell progresses through mitosis. Ark1 activity depends upon bir1 function and phosphorylation. Ark1 with bir1 function is required for full-scale association with kinetochores and formation of a complex with mad3.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi163 – 1631ZincPROSITE-ProRule annotation
Metal bindingi166 – 1661ZincPROSITE-ProRule annotation
Metal bindingi183 – 1831ZincPROSITE-ProRule annotation
Metal bindingi190 – 1901ZincPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • mitotic chromosome condensation Source: PomBase
  • mitotic cytokinesis Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • mitotic spindle assembly Source: GO_Central
  • protein localization to kinetochore Source: PomBase
  • protein localization to nucleolar rDNA repeats Source: PomBase
  • regulation of signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein bir1
Alternative name(s):
Chromosome segregation protein cut17
Gene namesi
Name:bir1
Synonyms:cut17, pbh1
ORF Names:SPCC962.02c, SPCP31B10.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC962.02c.
PomBaseiSPCC962.02c. bir1.

Subcellular locationi

GO - Cellular componenti

  • chromosome passenger complex Source: PomBase
  • condensed nuclear chromosome kinetochore Source: PomBase
  • cytoplasm Source: GO_Central
  • mitotic spindle Source: PomBase
  • mitotic spindle midzone Source: PomBase
  • nuclear chromatin Source: PomBase
  • nuclear pericentric heterochromatin Source: PomBase
  • nucleus Source: PomBase
  • spindle microtubule Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi976 – 9761C → Y in bir1-46; temperature-sensitive. 1 Publication
Mutagenesisi990 – 9901A → T in cut17-275; temperature-sensitive. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 997997Protein bir1PRO_0000122387Add
BLAST

Post-translational modificationi

Phosphorylated by ark1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14064.

Interactioni

Subunit structurei

Interacts with ark1 and mad3 to form part of the mad2 complex involved in checkpoint activation.1 Publication

Protein-protein interaction databases

BioGridi275454. 13 interactions.
DIPiDIP-59223N.
MINTiMINT-4670154.

Structurei

3D structure databases

ProteinModelPortaliO14064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 9975BIR 1Add
BLAST
Repeati120 – 19475BIR 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi80 – 834Poly-Asp
Compositional biasi312 – 3198Poly-Asp
Compositional biasi487 – 4904Poly-Ser

Sequence similaritiesi

Contains 2 BIR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiO14064.
OrthoDBiEOG092C4HVT.

Family and domain databases

Gene3Di1.10.1170.10. 2 hits.
InterProiIPR001370. BIR_rpt.
[Graphical view]
PfamiPF00653. BIR. 2 hits.
[Graphical view]
SMARTiSM00238. BIR. 2 hits.
[Graphical view]
PROSITEiPS50143. BIR_REPEAT_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O14064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPITSSSKR RWNRFRREMC NYSKRLDTFQ KKKWPRAKPT PETLATVGFY
60 70 80 90 100
YNPISESNSE ERLDNVTCYM CTKSFYDWED DDDPLKEHIT HSPSCPWAYI
110 120 130 140 150
LSSKNNPNQN PQAAALTKCR EQTFVDKVWP YTNRPDYHCE PSVMAASGFV
160 170 180 190 200
YNPTADAKDA AHCLYCDINL HDWEPDDDPY TEHKRRRADC VFFTWKDPNS
210 220 230 240 250
LSPTKLSFLS TSNIDPEDLT EDNSILPVSP TRDSTKSHKT LNFSPSRKNN
260 270 280 290 300
LNARPLTMSL YTNTSEEKDS QPTRAPQSPT KPVLLTAPRR KNKSPKKSKP
310 320 330 340 350
AVFKPVKPIF SDEDEDDDDL TASQPFSKGI CNDSMQVAKK NFTEEIPLKE
360 370 380 390 400
DEKDNELEHL VSPATSVHTT VSDITGHQSV TDESDEQNNC MSTPPKIEIE
410 420 430 440 450
SKIEEEISVV SKSKEISSSV SSVGKEQNHT EKQVAIETPE QQKVEKEDEH
460 470 480 490 500
LNLQGSFIEE STKQPISSKP STSSPDMTDA ATGGRVSSSS FRDKILQTNF
510 520 530 540 550
SPRSTIDSFS NISKKRNSEE ANDENDETNL KIPIPEKKRK FQEVLQSKNI
560 570 580 590 600
LVSSTEDSHE PVKVTEDSQT AIHVSKFEDL ENKSMESEQS LQLLSESEND
610 620 630 640 650
DKPLIDLIPL LAIKRKDNLV SGVLEKGKST STSKTKFDTS IVDFIEKPKT
660 670 680 690 700
EISEVLPEEK RKAICDESQT VRVSIDRGVT KTRDVSSPVS DEKSENVNHE
710 720 730 740 750
EANSGHTVMN VHSSLDPQPI VQPNELESGS YLKDLPDRNV GNSEKVTFQE
760 770 780 790 800
DDINSPKLQS KNNQTVEAVN TETSDKLQEK EANHELENIE KIEEKLTEVD
810 820 830 840 850
KVSLSDAFPD QEIKNSRTSV QNGTRSVSKN TPEKETKVDK IDNVSKKDVE
860 870 880 890 900
TSPGSCETSS AFAKTYAEKE VTSINLPSVR KPLDESYYDH SISPFDPLCQ
910 920 930 940 950
SSFLAPQTPV KSKHALPLVE ANAPPWEPID FSSLLESPVP NPVEPNKLSE
960 970 980 990
KELDMTVEQW IKFMYAKCAK EFEEACEEKI EWLLEEGKRA EEYIQNL
Length:997
Mass (Da):112,580
Last modified:January 1, 1998 - v1
Checksum:i952A6BAFA5C489F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031034 mRNA. Translation: BAA83415.1.
CU329672 Genomic DNA. Translation: CAA20434.1.
AB027919 Genomic DNA. Translation: BAA87223.1.
PIRiT43523.
RefSeqiNP_587866.3. NM_001022859.3.

Genome annotation databases

EnsemblFungiiSPCC962.02c.1; SPCC962.02c.1:pep; SPCC962.02c.
GeneIDi2538875.
KEGGispo:SPCC962.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031034 mRNA. Translation: BAA83415.1.
CU329672 Genomic DNA. Translation: CAA20434.1.
AB027919 Genomic DNA. Translation: BAA87223.1.
PIRiT43523.
RefSeqiNP_587866.3. NM_001022859.3.

3D structure databases

ProteinModelPortaliO14064.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275454. 13 interactions.
DIPiDIP-59223N.
MINTiMINT-4670154.

Proteomic databases

MaxQBiO14064.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC962.02c.1; SPCC962.02c.1:pep; SPCC962.02c.
GeneIDi2538875.
KEGGispo:SPCC962.02c.

Organism-specific databases

EuPathDBiFungiDB:SPCC962.02c.
PomBaseiSPCC962.02c. bir1.

Phylogenomic databases

InParanoidiO14064.
OrthoDBiEOG092C4HVT.

Miscellaneous databases

PROiO14064.

Family and domain databases

Gene3Di1.10.1170.10. 2 hits.
InterProiIPR001370. BIR_rpt.
[Graphical view]
PfamiPF00653. BIR. 2 hits.
[Graphical view]
SMARTiSM00238. BIR. 2 hits.
[Graphical view]
PROSITEiPS50143. BIR_REPEAT_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBIR1_SCHPO
AccessioniPrimary (citable) accession number: O14064
Secondary accession number(s): Q9USG4, Q9UTZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.