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Protein

Probable histidinol-phosphatase

Gene

SPCC1672.01

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + H2O = L-histidinol + phosphate.

Pathwayi: L-histidine biosynthesis

This protein is involved in step 8 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (his1)
  2. Histidine biosynthesis bifunctional protein his7 (his7)
  3. Histidine biosynthesis bifunctional protein his7 (his7)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (SPAC3F10.09)
  5. Imidazole glycerol phosphate synthase hisHF (his4)
  6. Imidazoleglycerol-phosphate dehydratase (his5)
  7. Histidinol-phosphate aminotransferase (his3)
  8. Probable histidinol-phosphatase (SPCC1672.01)
  9. Histidinol dehydrogenase (his2)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00013.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histidinol-phosphatase (EC:3.1.3.15)
Short name:
HolPase
Gene namesi
ORF Names:SPCC1672.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1672.01.
PomBaseiSPCC1672.01.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Probable histidinol-phosphatasePRO_0000122321Add
BLAST

Proteomic databases

MaxQBiO14059.

Interactioni

Protein-protein interaction databases

MINTiMINT-4670120.

Structurei

3D structure databases

ProteinModelPortaliO14059.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PHP hydrolase family. HisK subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000170774.
InParanoidiO14059.
KOiK04486.
OMAiDDSHGPH.
OrthoDBiEOG7T7H3X.
PhylomeDBiO14059.

Family and domain databases

InterProiIPR010140. Histidinol_P_phosphatase_HisJ.
IPR004013. PHP_dom.
IPR016195. Pol/histidinol_Pase-like.
[Graphical view]
PANTHERiPTHR21039. PTHR21039. 1 hit.
PfamiPF02811. PHP. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 1 hit.
TIGRFAMsiTIGR01856. hisJ_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

O14059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPISSHSHSG QFCLHAQGKL EDVIQEAIQQ GFQSFSFTEH TPRDRVEDLY
60 70 80 90 100
PEELHLQPED LFKTFDEYVN EARRLKQNYG DQINILIGAE TEYIRPESVE
110 120 130 140 150
LLKSLNTKYN LDYFVGSVHH VNSIPIDFSP ELWQKALQHV GNNPEQLFID
160 170 180 190 200
YFEHQYDLMQ RLHPLVIGHF DLICLFAPED AKEVFKNSKS VWELIQRNIK
210 220 230 240 250
YAVSYGGIFE INTSAFRKGW KTAYPQQRLL ELMVEQGAQL TLSDDSHGPH
260 270 280 290 300
QVGLNYHLAK SYLDKCGITS LCMIEKGPDG NGTVVKNVTV DNVWSKFVGT

NGITNT
Length:306
Mass (Da):35,050
Last modified:January 1, 1998 - v1
Checksum:i03973248225364EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20439.1.
PIRiT41045.
RefSeqiNP_587872.3. NM_001022864.3.

Genome annotation databases

EnsemblFungiiSPCC1672.01.1; SPCC1672.01.1:pep; SPCC1672.01.
GeneIDi2538785.
KEGGispo:SPCC1672.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20439.1.
PIRiT41045.
RefSeqiNP_587872.3. NM_001022864.3.

3D structure databases

ProteinModelPortaliO14059.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4670120.

Proteomic databases

MaxQBiO14059.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1672.01.1; SPCC1672.01.1:pep; SPCC1672.01.
GeneIDi2538785.
KEGGispo:SPCC1672.01.

Organism-specific databases

EuPathDBiFungiDB:SPCC1672.01.
PomBaseiSPCC1672.01.

Phylogenomic databases

HOGENOMiHOG000170774.
InParanoidiO14059.
KOiK04486.
OMAiDDSHGPH.
OrthoDBiEOG7T7H3X.
PhylomeDBiO14059.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00013.

Miscellaneous databases

PROiO14059.

Family and domain databases

InterProiIPR010140. Histidinol_P_phosphatase_HisJ.
IPR004013. PHP_dom.
IPR016195. Pol/histidinol_Pase-like.
[Graphical view]
PANTHERiPTHR21039. PTHR21039. 1 hit.
PfamiPF02811. PHP. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 1 hit.
TIGRFAMsiTIGR01856. hisJ_fam. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiHIS9_SCHPO
AccessioniPrimary (citable) accession number: O14059
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.