ID   GUAD_SCHPO              Reviewed;         527 AA.
AC   O14057;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 54.
DE   RecName: Full=Probable guanine deaminase;
DE            Short=Guanase;
DE            Short=Guanine aminase;
DE            EC=3.5.4.3;
DE   AltName: Full=Guanine aminohydrolase;
DE            Short=GAH;
GN   ORFNames=SPCC1672.03c;
OS   Schizosaccharomyces pombe (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales;
OC   Schizosaccharomycetaceae; Schizosaccharomyces.
OX   NCBI_TaxID=4896;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38366 / 972;
RX   MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA   Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA   Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA   Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA   James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA   Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA   Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA   Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA   Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA   Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA   Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA   Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA   Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA   Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA   Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA   Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA   Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA   Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA   Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA   Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA   Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA   Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Catalyzes the hydrolytic deamination of guanine,
CC       producing xanthine and ammonia (By similarity).
CC   -!- CATALYTIC ACTIVITY: Guanine + H(2)O = xanthine + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Purine metabolism; guanine degradation; xanthine from
CC       guanine: step 1/1.
CC   -!- SIMILARITY: Belongs to the ATZ/TRZ family.
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DR   EMBL; CU329672; CAA20441.1; -; Genomic_DNA.
DR   PIR; T41047; T41047.
DR   RefSeq; NP_587874.1; -.
DR   GeneID; 2539231; -.
DR   KEGG; spo:SPCC1672.03c; -.
DR   NMPDR; fig|4896.1.peg.212; -.
DR   GeneDB_Spombe; SPCC1672.03c; -.
DR   OMA; O14057; SESDWEH.
DR   BioCyc; SPOM-XXX-01:SPOM-XXX-01-002219-MON; -.
DR   BRENDA; 3.5.4.3; 653.
DR   ArrayExpress; O14057; -.
DR   GO; GO:0005829; C:cytosol; IDA:GeneDB_SPombe.
DR   GO; GO:0008892; F:guanine deaminase activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR006680; Amidohydro_1.
DR   InterPro; IPR014311; Guanine_deaminase.
DR   PANTHER; PTHR11271:SF6; Guanine_deaminase; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   TIGRFAMs; TIGR02967; guan_deamin; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Hydrolase; Metal-binding; Zinc.
FT   CHAIN         1    527       Probable guanine deaminase.
FT                                /FTId=PRO_0000122301.
FT   METAL        79     79       Zinc; via tele nitrogen (By similarity).
FT   METAL        81     81       Zinc; via tele nitrogen (By similarity).
FT   METAL       239    239       Zinc; via tele nitrogen (By similarity).
FT   METAL       329    329       Zinc (By similarity).
FT   BINDING      84     84       Substrate (By similarity).
FT   BINDING     212    212       Substrate (By similarity).
FT   BINDING     242    242       Substrate (By similarity).
FT   BINDING     278    278       Substrate (By similarity).
SQ   SEQUENCE   527 AA;  58047 MW;  23D9A3F1117601C1 CRC64;
     MDGHTCDVFV GKLIHTPSLG ELEITDATVG VYNGKIVFLE KSMTPKTLEE AKSHHLLKEA
     TIHKLKPLQF MFPGLIDTHI HAPQYPNSGI GIDVPLLQWL EKYTFPLESS LADLEEARQV
     YKRVVERTLS NGTTFASYFS TLHTPTSALL AEICYSYGQR AYIGKCNMNN LSPDHYCEKS
     AESSLEATRQ LISYMSILDP KREMVTPIIT PRFAPSCTED LLSGCGELAE KHNLPIQTHI
     SENTSEIELV KELFPERKSY ADVYDYYKLL TPQTILAHAI HLEDEEIELL TKRSSGISHC
     PTSNSILASG LANVRKLLDS GINVGLGTDV SGGYAPSILI ALRHAAMTSR SLSYVLGDPK
     VMLDLSELLY LATQGGAEVV SRGDQVGSFA VGKYWDALIV DLSAETHSCV DIFERDTWPV
     MLSKWVFTSD DRNLAQVWVN GRLVSGFEMK ANLKNSTPLT NGVTSSGHQV FKELTQAHLL
     PRTQCVDTPP SCCGGHCCKE ESCRTENCKG AYPANATVTV EEDSGMS
//