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Protein

Probable V-type proton ATPase 20 kDa proteolipid subunit

Gene

vma16

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei94Essential for proton translocationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-1222556 ROS, RNS production in phagocytes
R-SPO-77387 Insulin receptor recycling
R-SPO-917977 Transferrin endocytosis and recycling

Names & Taxonomyi

Protein namesi
Recommended name:
Probable V-type proton ATPase 20 kDa proteolipid subunit
Short name:
V-ATPase 20 kDa proteolipid subunit
Alternative name(s):
Vacuolar proton pump 20 kDa proteolipid subunit
Gene namesi
Name:vma16
ORF Names:SPAC2C4.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2C4.13
PomBaseiSPAC2C4.13 vma16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3LumenalSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 46CytoplasmicSequence analysisAdd BLAST22
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 86LumenalSequence analysisAdd BLAST19
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 130CytoplasmicSequence analysisAdd BLAST23
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 170LumenalSequence analysisAdd BLAST19
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 199CytoplasmicSequence analysis8

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717791 – 199Probable V-type proton ATPase 20 kDa proteolipid subunitAdd BLAST199

Proteomic databases

PaxDbiO14046
PRIDEiO14046

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC2C4.13.1

Structurei

3D structure databases

ProteinModelPortaliO14046
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000056522
InParanoidiO14046
KOiK03661
OMAiTSPYMWS
OrthoDBiEOG092C5DS5
PhylomeDBiO14046

Family and domain databases

InterProiView protein in InterPro
IPR002379 ATPase_proteolipid_c-like_dom
IPR000245 ATPase_proteolipid_csu
IPR035921 F/V-ATP_Csub_sf
PfamiView protein in Pfam
PF00137 ATP-synt_C, 2 hits
PRINTSiPR00122 VACATPASE
SUPFAMiSSF81333 SSF81333, 2 hits

Sequencei

Sequence statusi: Complete.

O14046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFSTSLWT TTVMSIIVGL YMLFHNSGES FDFGSFLLDT SPYTWGLLGI
60 70 80 90 100
ASCVAFGIIG AAWGIFICGT SILGGAVKAP RIKTKNLISI IFCEVVAIYS
110 120 130 140 150
LIIAIVFSAK INDINPAGFY TKSHYYTGFA LFWGGITVGL CNLICGVCVG
160 170 180 190
ITGSSAALAD AQDASLFVKV LVVEIFGSVL GLFGLIVGLL IGGKASDFS
Length:199
Mass (Da):20,886
Last modified:January 1, 1998 - v1
Checksum:i3403B3AA5266124A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16373.1
PIRiT38524
RefSeqiNP_594516.1, NM_001019945.2

Genome annotation databases

EnsemblFungiiSPAC2C4.13.1; SPAC2C4.13.1:pep; SPAC2C4.13
GeneIDi2541999
KEGGispo:SPAC2C4.13

Entry informationi

Entry nameiVATO_SCHPO
AccessioniPrimary (citable) accession number: O14046
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health