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Protein

Probable V-type proton ATPase 20 kDa proteolipid subunit

Gene

vma16

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei94 – 941Essential for proton translocationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-1222556. ROS, RNS production in response to bacteria.
R-SPO-77387. Insulin receptor recycling.
R-SPO-917977. Transferrin endocytosis and recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable V-type proton ATPase 20 kDa proteolipid subunit
Short name:
V-ATPase 20 kDa proteolipid subunit
Alternative name(s):
Vacuolar proton pump 20 kDa proteolipid subunit
Gene namesi
Name:vma16
ORF Names:SPAC2C4.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2C4.13.
PomBaseiSPAC2C4.13. vma16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33LumenalSequence analysis
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Topological domaini25 – 4622CytoplasmicSequence analysisAdd
BLAST
Transmembranei47 – 6721HelicalSequence analysisAdd
BLAST
Topological domaini68 – 8619LumenalSequence analysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST
Topological domaini108 – 13023CytoplasmicSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Topological domaini152 – 17019LumenalSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Topological domaini192 – 1998CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Probable V-type proton ATPase 20 kDa proteolipid subunitPRO_0000071779Add
BLAST

Interactioni

Protein-protein interaction databases

MINTiMINT-4670042.

Structurei

3D structure databases

ProteinModelPortaliO14046.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000056522.
InParanoidiO14046.
KOiK03661.
OMAiVYSARIT.
OrthoDBiEOG79W9J3.
PhylomeDBiO14046.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c-like_dom.
IPR000245. ATPase_proteolipid_csu.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.

Sequencei

Sequence statusi: Complete.

O14046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFSTSLWT TTVMSIIVGL YMLFHNSGES FDFGSFLLDT SPYTWGLLGI
60 70 80 90 100
ASCVAFGIIG AAWGIFICGT SILGGAVKAP RIKTKNLISI IFCEVVAIYS
110 120 130 140 150
LIIAIVFSAK INDINPAGFY TKSHYYTGFA LFWGGITVGL CNLICGVCVG
160 170 180 190
ITGSSAALAD AQDASLFVKV LVVEIFGSVL GLFGLIVGLL IGGKASDFS
Length:199
Mass (Da):20,886
Last modified:January 1, 1998 - v1
Checksum:i3403B3AA5266124A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16373.1.
PIRiT38524.
RefSeqiNP_594516.1. NM_001019945.2.

Genome annotation databases

EnsemblFungiiSPAC2C4.13.1; SPAC2C4.13.1:pep; SPAC2C4.13.
GeneIDi2541999.
KEGGispo:SPAC2C4.13.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAB16373.1.
PIRiT38524.
RefSeqiNP_594516.1. NM_001019945.2.

3D structure databases

ProteinModelPortaliO14046.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4670042.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC2C4.13.1; SPAC2C4.13.1:pep; SPAC2C4.13.
GeneIDi2541999.
KEGGispo:SPAC2C4.13.

Organism-specific databases

EuPathDBiFungiDB:SPAC2C4.13.
PomBaseiSPAC2C4.13. vma16.

Phylogenomic databases

HOGENOMiHOG000056522.
InParanoidiO14046.
KOiK03661.
OMAiVYSARIT.
OrthoDBiEOG79W9J3.
PhylomeDBiO14046.

Enzyme and pathway databases

ReactomeiR-SPO-1222556. ROS, RNS production in response to bacteria.
R-SPO-77387. Insulin receptor recycling.
R-SPO-917977. Transferrin endocytosis and recycling.

Miscellaneous databases

PROiO14046.

Family and domain databases

InterProiIPR002379. ATPase_proteolipid_c-like_dom.
IPR000245. ATPase_proteolipid_csu.
[Graphical view]
PfamiPF00137. ATP-synt_C. 2 hits.
[Graphical view]
PRINTSiPR00122. VACATPASE.
SUPFAMiSSF81333. SSF81333. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiVATO_SCHPO
AccessioniPrimary (citable) accession number: O14046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.