Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

set2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

  • histone methyltransferase activity (H3-K36 specific) Source: PomBase

GO - Biological processi

  • histone H3-K36 methylation Source: PomBase
  • regulation of transcription by RNA polymerase II Source: PomBase
  • transcription elongation from RNA polymerase II promoter Source: PomBase

Keywordsi

Molecular functionMethyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-SPO-3214841 PKMTs methylate histone lysines
R-SPO-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
Lysine N-methyltransferase 3
SET domain-containing protein 2
Gene namesi
Name:set2
Synonyms:kmt3
ORF Names:SPAC29B12.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC29B12.02c
PomBaseiSPAC29B12.02c set2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002697921 – 798Histone-lysine N-methyltransferase, H3 lysine-36 specificAdd BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67Phosphoserine1 Publication1
Modified residuei545Phosphothreonine1 Publication1
Modified residuei594Phosphoserine1 Publication1
Modified residuei596Phosphoserine1 Publication1
Modified residuei783Phosphothreonine1 Publication1
Modified residuei785Phosphothreonine1 Publication1
Modified residuei787Phosphoserine1 Publication1
Modified residuei789Phosphoserine1 Publication1
Modified residuei793Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO14026
PaxDbiO14026
PRIDEiO14026

PTM databases

iPTMnetiO14026

Interactioni

Protein-protein interaction databases

BioGridi278547, 22 interactors
STRINGi4896.SPAC29B12.02c.1

Structurei

3D structure databases

ProteinModelPortaliO14026
SMRiO14026
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 178AWSPROSITE-ProRule annotationAdd BLAST55
Domaini180 – 297SETPROSITE-ProRule annotationAdd BLAST118
Domaini304 – 320Post-SETPROSITE-ProRule annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili627 – 674Sequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 78Ser-richAdd BLAST57

Domaini

The AWS and SET domains are necessary for transcription repression.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiO14026
KOiK11423
OrthoDBiEOG092C3T9B
PhylomeDBiO14026

Family and domain databases

InterProiView protein in InterPro
IPR006560 AWS_dom
IPR025788 Hist-Lys_N-MeTrfase_SET2_fun
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR013257 SRI
IPR035441 TFIIS/LEDGF_dom_sf
IPR017923 TFIIS_N
PfamiView protein in Pfam
PF08711 Med26, 1 hit
PF00856 SET, 1 hit
PF08236 SRI, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF47676 SSF47676, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS51568 SAM_MT43_SET2_1, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

O14026-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTASSLSVL TPLNEENVDR KSSWSKDTIA VQAVGSSPSS SSSHDFESKE
60 70 80 90 100
DAEGMNKDES APSPSTSSPS SASSRSQSKY VRKEALPPQL FHHLDSAKDK
110 120 130 140 150
ALTTFEEIQE CQYASANIGK PPENEAMICD CRPHWVDGVN VACGHGSNCI
160 170 180 190 200
NRMTSIECTD EDNVCGPSCQ NQRFQRHEFA KVDVFLTEKK GFGLRADANL
210 220 230 240 250
PKDTFVYEYI GEVIPEQKFR KRMRQYDSEG IKHFYFMMLQ KGEYIDATKR
260 270 280 290 300
GSLARFCNHS CRPNCYVDKW MVGDKLRMGI FCKRDIIRGE ELTFDYNVDR
310 320 330 340 350
YGAQAQPCYC GEPCCVGYIG GKTQTEAQSK LPENVREALG IEDEEDSWEN
360 370 380 390 400
ITARRQRRKK GIDETSKIIE EVQPTPLTSE SATKVIGVLL QTKDDLLTRK
410 420 430 440 450
LMERIFLTSD PSVCRSIIAL RGYNIFGLML KKFSIDIEFI LRSIKTMLSW
460 470 480 490 500
PRLTRNKIQD SNIEPVVQEF CDHENEEVKD HAKTLLKEWE SLEIAYRIPR
510 520 530 540 550
RKPGQVAPQS TNAEPSNNQS NPPLRDQEPQ RGDKGDIKSA INNSTEDLSK
560 570 580 590 600
KHPALHSSRP SDSRSRSKFG NDYQSHSKHN LFRKNSFPKR RRLSNSDTPS
610 620 630 640 650
ETTTPNNEQE QVSNQANKVD LNKIISAAME SVNQKNVLKA QKEEEERIAQ
660 670 680 690 700
QKREEKRRLA YEESLKRHAK KLHEKKTKSS QDATIDHHLT SHSPESIAFK
710 720 730 740 750
AVLAKFFANK TARYQEKLGK AEFKLRVKKM TEIILKKHIQ LVLSKKEKAL
760 770 780 790
PDELSDSQQR KLRVWAFRYL DTVVSRSGTA TTTPTDSPSI GESPKKAA
Length:798
Mass (Da):90,679
Last modified:January 1, 1998 - v1
Checksum:i4ACEE9D1705A639E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB16247.1
PIRiT38490
RefSeqiNP_594980.1, NM_001020411.2

Genome annotation databases

EnsemblFungiiSPAC29B12.02c.1; SPAC29B12.02c.1:pep; SPAC29B12.02c
GeneIDi2542070
KEGGispo:SPAC29B12.02c

Similar proteinsi

Entry informationi

Entry nameiSET2_SCHPO
AccessioniPrimary (citable) accession number: O14026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health