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Protein

Probable elongator complex protein 3

Gene

elp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts as catalytic subunit of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi96Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi106Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi109Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1

GO - Molecular functioni

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • regulation of cytoplasmic translational fidelity Source: PomBase
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW
  • tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation Source: PomBase

Keywordsi

Molecular functionAcyltransferase, Chromatin regulator, Transferase
Biological processProtein transport, Transcription, Transcription regulation, Transport
LigandIron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:elp3
ORF Names:SPAC29A4.20
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC29A4.20
PomBaseiSPAC29A4.20 elp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003103601 – 544Probable elongator complex protein 3Add BLAST544

Proteomic databases

MaxQBiO14023
PaxDbiO14023
PRIDEiO14023

PTM databases

iPTMnetiO14023

Interactioni

Protein-protein interaction databases

BioGridi278111, 332 interactors
STRINGi4896.SPAC29A4.20.1

Structurei

3D structure databases

ProteinModelPortaliO14023
SMRiO14023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini393 – 544N-acetyltransferasePROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Belongs to the ELP3 family.Curated

Phylogenomic databases

HOGENOMiHOG000227514
InParanoidiO14023
KOiK07739
OMAiSYTGKEP
OrthoDBiEOG092C1F4W
PhylomeDBiO14023

Family and domain databases

Gene3Di3.80.30.20, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR034687 ELP3-like
IPR006638 Elp3/MiaB/NifB
IPR000182 GNAT_dom
IPR032432 Radical_SAM_C
IPR007197 rSAM
IPR023404 rSAM_horseshoe
PANTHERiPTHR11135:SF0 PTHR11135:SF0, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF04055 Radical_SAM, 1 hit
PF16199 Radical_SAM_C, 1 hit
PIRSFiPIRSF005669 Hist_AcTrfase_ELP3, 1 hit
SFLDiSFLDF00344 ELP3-like, 1 hit
SFLDS00029 Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR01211 ELP3, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

O14023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSSLAFLK AKACAEIVAE LIASENQNKV INLNALKMRI SKKHQLSESP
60 70 80 90 100
RLTDIIAAIP PDAYLKESLM RKLRAKPVRT ASGIAVVAVM CKPHRCPHIA
110 120 130 140 150
MTGNVCVYCP GGPDSDFEYS TQSYTGYEPT SMRAIRARYD PYEQARGRVE
160 170 180 190 200
QLRSLGHTVD KVEYIIMGGT FMSLPESYRH TFIANLHNAL SGATTEDLDE
210 220 230 240 250
AVKFSEQSET KCVGITIETR PDYCLDQHLD EMLRYGCTRL EIGVQSVYED
260 270 280 290 300
VARDTNRGHT VKAVCETFQL AKDTGYKVVT HMMPDLPNVG MERDIFQFQE
310 320 330 340 350
YFENPAFRTD GLKLYPTLVI RGTGLYELWK TGRYKNYTPN ALVDLIARIL
360 370 380 390 400
ALVPPWTRIY RIQRDIPMPL VSSGVETGNL RELALNRMRD LGTKCRDIRA
410 420 430 440 450
REVGMQEVHH KIHPEQVELL RRDYTANGGW ETFLSYEDPK QDILIGLLRL
460 470 480 490 500
RQCSDKTYRP EFTSQPTSLV RELHVYGSAV PVHSRDPKKF QHQGFGTLLL
510 520 530 540
EEAERIAKYE HGSKKISVIS GVGVRKYYQK LGYTLDGPYM SKWL
Length:544
Mass (Da):61,850
Last modified:January 1, 1998 - v1
Checksum:iACF2CF7C49C6AB5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB10146.1
PIRiT38469
RefSeqiNP_594862.1, NM_001020291.2

Genome annotation databases

EnsemblFungiiSPAC29A4.20.1; SPAC29A4.20.1:pep; SPAC29A4.20
GeneIDi2541614
KEGGispo:SPAC29A4.20

Similar proteinsi

Entry informationi

Entry nameiELP3_SCHPO
AccessioniPrimary (citable) accession number: O14023
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health