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O14023

- ELP3_SCHPO

UniProt

O14023 - ELP3_SCHPO

Protein

Probable elongator complex protein 3

Gene

elp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Acts as catalytic subunit of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Cofactori

    Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.By similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: PomBase
    2. iron-sulfur cluster binding Source: InterPro

    GO - Biological processi

    1. histone acetylation Source: PomBase
    2. protein transport Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW
    5. tRNA wobble uridine modification Source: PomBase

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Protein transport, Transcription, Transcription regulation, Transport

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable elongator complex protein 3 (EC:2.3.1.48)
    Gene namesi
    Name:elp3
    ORF Names:SPAC29A4.20
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC29A4.20.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. Elongator holoenzyme complex Source: PomBase
    4. nuclear chromatin Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 544544Probable elongator complex protein 3PRO_0000310360Add
    BLAST

    Proteomic databases

    MaxQBiO14023.

    Interactioni

    Protein-protein interaction databases

    BioGridi278111. 333 interactions.
    MINTiMINT-4669868.
    STRINGi4896.SPAC29A4.20-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO14023.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini393 – 544152N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ELP3 family.Curated
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1243.
    HOGENOMiHOG000227514.
    KOiK07739.
    OMAiGYKVVSH.
    OrthoDBiEOG7Z95VX.
    PhylomeDBiO14023.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    TIGRFAMsiTIGR01211. ELP3. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O14023-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTSSLAFLK AKACAEIVAE LIASENQNKV INLNALKMRI SKKHQLSESP    50
    RLTDIIAAIP PDAYLKESLM RKLRAKPVRT ASGIAVVAVM CKPHRCPHIA 100
    MTGNVCVYCP GGPDSDFEYS TQSYTGYEPT SMRAIRARYD PYEQARGRVE 150
    QLRSLGHTVD KVEYIIMGGT FMSLPESYRH TFIANLHNAL SGATTEDLDE 200
    AVKFSEQSET KCVGITIETR PDYCLDQHLD EMLRYGCTRL EIGVQSVYED 250
    VARDTNRGHT VKAVCETFQL AKDTGYKVVT HMMPDLPNVG MERDIFQFQE 300
    YFENPAFRTD GLKLYPTLVI RGTGLYELWK TGRYKNYTPN ALVDLIARIL 350
    ALVPPWTRIY RIQRDIPMPL VSSGVETGNL RELALNRMRD LGTKCRDIRA 400
    REVGMQEVHH KIHPEQVELL RRDYTANGGW ETFLSYEDPK QDILIGLLRL 450
    RQCSDKTYRP EFTSQPTSLV RELHVYGSAV PVHSRDPKKF QHQGFGTLLL 500
    EEAERIAKYE HGSKKISVIS GVGVRKYYQK LGYTLDGPYM SKWL 544
    Length:544
    Mass (Da):61,850
    Last modified:January 1, 1998 - v1
    Checksum:iACF2CF7C49C6AB5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB10146.1.
    PIRiT38469.
    RefSeqiNP_594862.1. NM_001020291.2.

    Genome annotation databases

    EnsemblFungiiSPAC29A4.20.1; SPAC29A4.20.1:pep; SPAC29A4.20.
    GeneIDi2541614.
    KEGGispo:SPAC29A4.20.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAB10146.1 .
    PIRi T38469.
    RefSeqi NP_594862.1. NM_001020291.2.

    3D structure databases

    ProteinModelPortali O14023.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278111. 333 interactions.
    MINTi MINT-4669868.
    STRINGi 4896.SPAC29A4.20-1.

    Proteomic databases

    MaxQBi O14023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC29A4.20.1 ; SPAC29A4.20.1:pep ; SPAC29A4.20 .
    GeneIDi 2541614.
    KEGGi spo:SPAC29A4.20.

    Organism-specific databases

    PomBasei SPAC29A4.20.

    Phylogenomic databases

    eggNOGi COG1243.
    HOGENOMi HOG000227514.
    KOi K07739.
    OMAi GYKVVSH.
    OrthoDBi EOG7Z95VX.
    PhylomeDBi O14023.

    Miscellaneous databases

    NextBioi 20802708.
    PROi O14023.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    TIGRFAMsi TIGR01211. ELP3. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiELP3_SCHPO
    AccessioniPrimary (citable) accession number: O14023
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3